A Potential Route of Capsaicin to Its Binding Site in the TRPV1 Ion Channel

Autor: Carmen Domene, Leonardo Darré, Victoria Oakes, Saul Gonzalez-Resines

Publikováno v: Journal of Chemical Information and Modeling. 62:2481-2489

Transient receptor potential (TRP) ion channels are important pharmacological targets because of their role in the perception of pain, and so, understanding their chemical regulation is essential for the development of analgesic drugs. Among the curr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d1c57d23b7c0c6ca7c68f5b3894c9b
https://doi.org/10.1021/acs.jcim.1c01441

Insights into the Mechanisms of K+ Permeation in K+ Channels from Computer Simulations

Autor: Simone Furini, Victoria Oakes, Carmen Domene

Publikováno v: Oakes, V, Furini, S & Domene, C 2020, ' Insights into the mechanisms of K+ permeation in K+-channels from computer simulations ', Journal of Chemical Theory and Computation, vol. 16, no. 1, pp. 794-799 . https://doi.org/10.1021/acs.jctc.9b00971

Ion permeation, selectivity, and the behavior of the K + channel selectivity filter have been studied intensively in the previous two decades. The agreement among multiple approaches used to study ion flux in K + channels suggests a consensus mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c84c7db4f7429a56136eccd92f9255b
http://hdl.handle.net/11365/1112924

Insights into the Mechanisms of K

Autor: Victoria, Oakes, Simone, Furini, Carmen, Domene

Publikováno v: Journal of chemical theory and computation. 16(1)

Ion permeation, selectivity, and the behavior of the K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::414af4d15fa658fe09e25545d9f8432f
https://pubmed.ncbi.nlm.nih.gov/31809048

Influence of Cholesterol and Its Stereoisomers on Members of the Serotonin Receptor Family

Autor: Carmen Domene, Victoria Oakes

Publikováno v: Oakes, V & Domene, C 2019, ' Influence of Cholesterol and its Stereoisomers on Members of the Serotonin Receptor Family ', Journal of Molecular Biology, vol. 431, no. 8, pp. 1633-1649 . https://doi.org/10.1016/j.jmb.2019.02.030

Despite the ubiquity of cholesterol within the cell membrane, the mechanism by which it influences embedded proteins remains elusive. Numerous G-protein coupled receptors exhibit dramatic responses to membrane cholesterol with regard to the ligand-bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15921053c5954d978a07091d51fd2253
http://ora.ox.ac.uk/objects/uuid:

Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites

Autor: José A. Poveda, Andrés Morales, Carmen Domene, Victoria Oakes, Oscar Millet, Simone Furini, A. Marcela Giudici, M. Lourdes Renart, José M. González-Ros

Publikováno v: RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Poveda, J A, Giudici, A M, Renart, M L, Millet, O, Morales, A, González-Ros, J M, Oakes, V, Furini, S & Domene, C 2019, ' Modulation of the potassium channel KcsA by anionic phospholipids : Role of arginines at the non-annular lipid binding sites ', Biochimica Et Biophysica Acta-Biomembranes, vol. 1861, no. 10, 183029 . https://doi.org/10.1016/j.bbamem.2019.183029

The role of arginines R64 and R89 at non-annular lipid binding sites of KcsA, on the modulation of channel activity by anionic lipids has been investigated. In wild-type (WT) KcsA reconstituted into asolectin lipid membranes, addition of phosphatidic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf83f3b2e61b0bb80946164a972fee1f
http://hdl.handle.net/10045/95450