Multifaceted Analyses of Isolated Mitochondria Establish the Anticancer Drug 2-Hydroxyoleic Acid as an Inhibitor of Substrate Oxidation and an Activator of Complex IV-Dependent State 3 Respiration

Autor: Kumudesh Mishra, Mária Péter, Anna Maria Nardiello, Guy Keller, Victoria Llado, Paula Fernandez-Garcia, Ulf D. Kahlert, Dinorah Barasch, Ann Saada, Zsolt Török, Gábor Balogh, Pablo V. Escriba, Stefano Piotto, Or Kakhlon

Publikováno v: Cells, Vol 11, Iss 3, p 578 (2022)

The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) has been extensively investigated as a cancer therapy mainly based on its regulation of membrane lipid composition and structure, activating various cell fate pathways. We discovered, additionally,

Externí odkaz: https://doaj.org/article/b5983e526aa34671b2e539ab84515b5d

Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι

Autor: Yuki Nakanishi, Miguel Reina-Campos, Naoko Nakanishi, Victoria Llado, Lisa Elmen, Scott Peterson, Alex Campos, Surya K. De, Michael Leitges, Hiroki Ikeuchi, Maurizio Pellecchia, Richard S. Blumberg, Maria T. Diaz-Meco, Jorge Moscat

Publikováno v: Cell Reports, Vol 16, Iss 12, Pp 3297-3310 (2016)

Paneth cells are a highly specialized population of intestinal epithelial cells located in the crypt adjacent to Lgr5+ stem cells, from which they differentiate through a process that requires downregulation of the Notch pathway. Their ability to sto

Externí odkaz: https://doaj.org/article/31d643342d1545359bd952c2cdffb579

Abstract 4869: Furin and Notch signaling pathway as part of the 2OHOA landscape against glioblastoma

Autor: Raquel Rodríguez-Lorca, Roberto Beteta-Göbel, Ramón Román, Manuel Torres, Victoria Llado, Pablo V. Escribá, Paula Fernández-García

Publikováno v: Cancer Research. 83:4869-4869

Glioblastoma (GBM) is the most common and aggressive cancer tumor of the central nervous system, with only 12-15 months of patients’ median survival. Melitherapy is a novel therapeutic platform based on the regulation of the membrane’s structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bee333b9fe4815cb002129f1f58d9ef
https://doi.org/10.1158/1538-7445.am2023-4869

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

Autor: Maria T. Diaz-Meco, Mariano García-Arranz, Dolores C. García-Olmo, Susana Olmedillas-López, Hiroaki Kasashima, Javier F. Cáceres, Miguel Reina-Campos, Jorge Moscat, Victoria Llado, Phillip M. Shelton, Alex Campos, Li Ma, Damián García-Olmo, Yuki Nakanishi, Angeles Duran

Publikováno v: Cell Reports, Vol 23, Iss 4, Pp 1178-1191 (2018)
Recercat. Dipósit de la Recerca de Catalunya
instname
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Cell reports
Shelton, P M, Duran, A, Nakanishi, Y, Reina-Campos, M, Kasashima, H, Llado, V, Ma, L, Campos, A, García-Olmo, D, García-Arranz, M, García-Olmo, D C, Olmedillas-López, S, Caceres, J F, Diaz-Meco, M T & Moscat, J 2018, ' The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer ', Cell Reports, vol. 23, no. 4, pp. 1178-1191 . https://doi.org/10.1016/j.celrep.2018.03.118
Repositorio Abierto de la UdL
Universitad de Lleida
Biblos-e Archivo. Repositorio Institucional de la UAM

Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis. Given the importance of microRNAs (miRNAs) in regulating cellular plasticity, we performed an unbiased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2464fc2c949d4e7345cfbe4ae9d4852a
http://www.sciencedirect.com/science/article/pii/S2211124718304947

Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ

Autor: Michael Leitges, Miguel Reina-Campos, Angeles Duran, Yuki Nakanishi, Victoria Llado, Pedro Aza-Blanc, Phillip M. Shelton, Tomoko Yajima, Maria T. Diaz-Meco, Jorge Moscat, Juan F. Linares, A. F. C. Campos

Publikováno v: Cell Reports, Vol 10, Iss 5, Pp 740-754 (2015)

SummaryIntestinal epithelial homeostasis requires continuous renewal supported by stem cells located in the base of the crypt. Disruption of this balance results in failure to regenerate and initiates tumorigenesis. The β-catenin and Yap pathways in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e13e43500ea462e22f9b66eb73711db