Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Victoria L.C. Pallares"'
Autor:
Shyam H. Kamble, Samuel Obeng, Francisco León, Luis F. Restrepo, Tamara I. King, Erin C. Berthold, Siva Rama Raju Kanumuri, Lea R. Gamez-Jimenez, Victoria L.C. Pallares, Avi Patel, Nicholas P. Ho, Aidan Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Abhisheak Sharma, Takato Hiranita
Publikováno v:
J Pharmacol Exp Ther
Mitragynine, an opioidergic alkaloid present in Mitragyna speciosa (kratom), is metabolized by cytochrome P450 3A (CYP3A) to 7-hydroxymitragynine, a more potent opioid receptor agonist. The extent to which conversion to 7-hydroxymitragynine mediates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9288dd2b6b7ca7f4d59c89456a88b52
https://doi.org/10.1124/jpet.122.001525
https://doi.org/10.1124/jpet.122.001525
Autor:
Samuel Obeng, Francisco Leon, Avi Patel, Julio D. Zuarth Gonzalez, Lucas Chaves Da Silva, Luis F. Restrepo, Lea R. Gamez-Jimenez, Nicholas P. Ho, Maria P. Guerrero Calvache, Victoria L.C. Pallares, Justin A. Helmes, Sakura K. Shiomitsu, Paul L. Soto, Aidan J. Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Takato Hiranita
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:182-198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec28c628ae343e8d881cf992b62e1d4d
https://doi.org/10.1124/jpet.122.001192
https://doi.org/10.1124/jpet.122.001192
Autor:
Victoria L.C. Pallares, Anna E. Pennington, Morgan L. Crowley, Avi Patel, Morgan E. Reeves, Carolina Lopera-Londoño, Marco Mottinelli, Nicholas P. Ho, Francisco León, John D. Fortner, Christopher R. McCurdy, Luis F. Restrepo, Victoria A. Taylor, Jenny L. Wilkerson, Lance R. McMahon, Samuel Obeng, Takato Hiranita, Tobias Braun, Lea R. Gamez-Jimenez, Morgan R. Williamson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:410-427
Relationships between µ-opioid receptor (MOR) efficacy and effects of mitragynine and 7-hydroxymitragynine are not fully established. We assessed in vitro binding affinity and efficacy and discriminative stimulus effects together with antinociceptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72dcbea9c746af3f998d852e8075016a
https://doi.org/10.1124/jpet.120.000189
https://doi.org/10.1124/jpet.120.000189
Autor:
Lea R. Gamez-Jimenez, Lance R. McMahon, Nicholas P. Ho, Julio Zuarth Gonzalez, Victoria L.C. Pallares, Amsha Thadisetti, Marco Mottinelli, Christopher R. McCurdy, Morgan L. Crowley, Manuel G. Alvarez, Takato Hiranita, Samuel Obeng, Avi Patel, Elizabeth Kern, Luis F. Restrepo, Francisco León
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::358fc074f3825a1340a45b4616d8f57b
https://doi.org/10.1096/fasebj.2021.35.s1.05475
https://doi.org/10.1096/fasebj.2021.35.s1.05475
Autor:
Carolina Lopera-Londoño, Lea R. Gamez-Jimenez, Lance R. McMahon, Takato Hiranita, Victoria L.C. Pallares, Julio Zuarth Gonzalez, Avi Patel, Francisco León, Marco Mottinelli, Christopher R. McCurdy, Luis F. Restrepo, Samuel Obeng
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e9adf59f8c83acd683cc258da1e13b
https://doi.org/10.1096/fasebj.2021.35.s1.04764
https://doi.org/10.1096/fasebj.2021.35.s1.04764
Autor:
Christopher R. McCurdy, Tobias Braun, Lea R. Gamez-Jimenez, Luis F. Restrepo, Avi Patel, Morgan L. Crowley, Morgan E. Reeves, Lance R. McMahon, Victoria L.C. Pallares, Nicholas P. Ho, Takato Hiranita
Publikováno v:
J Pharmacol Toxicol Methods
Introduction Whole-body plethysmography (WBP) in unrestrained, non-anesthetized rodents is a preclinical method to assess the respiratory depressant effects of opioids, the leading cause of opioid overdose death in humans. However, low baseline respi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d175a9aabf40800c459af9934552e9f9
https://doi.org/10.1016/j.vascn.2021.107101
https://doi.org/10.1016/j.vascn.2021.107101