Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Victoria L. Flanary"'
Autor:
Emma F. Jones, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Brittany N. Lasseigne
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-16 (2024)
Abstract Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Many diseases are either caused by alterations in AS or by alterations to AS. Therefore, measuring AS accurately and effic
Externí odkaz:
https://doaj.org/article/886828797be44df2ac40fc1ae2c4e865
Autor:
Jennifer L. Fisher, Elizabeth J. Wilk, Vishal H. Oza, Sam E. Gary, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Anita B. Hjelmeland, Brittany N. Lasseigne
Publikováno v:
FEBS Open Bio, Vol 14, Iss 5, Pp 803-830 (2024)
Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease‐associated gene signature to identi
Externí odkaz:
https://doaj.org/article/f40949cccc344b50a5660d71408edfbd
Autor:
Jennifer L. Fisher, Emma F. Jones, Victoria L. Flanary, Avery S. Williams, Elizabeth J. Ramsey, Brittany N. Lasseigne
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-23 (2022)
Highlights Genetic, epigenetic, hormonal, immunological, metabolic, and environmental factors affect sex-biased drug responses. Drug repurposing approaches provide a significant advantage over novel drug development by reducing lengthy and costly cli
Externí odkaz:
https://doaj.org/article/a8821dfe23fd4b169cfc582a6557e6e3
Autor:
Victoria L. Flanary, Jennifer L. Fisher, Elizabeth J. Wilk, Timothy C. Howton, Brittany N. Lasseigne
As cancer remains resistant to several modes of treatment, novel therapeutics are still under active investigation to overcome treatment inefficacy in cancer. Given the high attrition rate of de novo drug discovery, drug screening, and drug repurposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::279e1db314bb1aa7021af039e6795952
https://doi.org/10.20944/preprints202305.1637.v1
https://doi.org/10.20944/preprints202305.1637.v1
Autor:
Ingrid Grummt, Sergey Mareninov, Holger Bierhoff, Paul S. Mischel, Hiroko Shimada, Lionel M.L. Chow, Nazanin Majd, Makoto Suematsu, Greg Lucey, Alexander Otto Eberhardt, Maya Asano, Yuki Ban, Kaori Kofuji, Eric P. Smith, Eric C. Holland, Noriaki Minami, Ralph J. DeBerardinis, Daisuke Yamashita, Ichiro Nakano, Kazutaka Sumita, Yoshiki Ikeda, Hirofumi Yoshino, Yuki Sugiura, Robert Bachoo, Lisa Lange, Akshiv Malhotra, Mika Sasaki, Risa Kawaguchi, Yonehiro Kanemura, Akiyoshi Hirayama, Annmarie Ramkissoon, William H. Yong, Masaru Mori, Trisha Wise-Draper, Tomoyoshi Soga, Dimitrios Anastasiou, Jumpei Terakawa, Juri Kiyokawa, Tatsuya Ozawa, Hiroaki Wakimoto, Kara Wolfe, Atsuo T. Sasaki, Nobuyuki Onishi, Satoshi Kofuji, Satsuki Ikeda, Craig Horbinski, Takiko Daikoku, Koichi Okumura, Mikako Warren, Shin Morioka, Hideyuki Saya, Naoya Sakamoto, Shuji Kitahara, Oltea Sampetrean, Wataru Yasui, Tomoyuki Mashimo, Victoria L. Flanary
Publikováno v:
Nature cell biology
In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally understood. Here
Autor:
Myriam Gorospe, Fen Zhou, Hongyi Zhou, Inna Sirota, Jeffrey Skolnick, Victoria L. Flanary, Nicola Zamboni, Hee Jin Cho, Xiaojia Guo, Harley I. Kornblum, Davide Botta, Mu Gao, Toru Kondo, David K. Crossman, Takeharu Kunieda, Shinobu Yamaguchi, Nakano Ma, Daisuke Yamashita, Zhenglong Gu, Ichiro Nakano, Do-Hyun Nam, Frances E. Lund, Saya Ozaki
Even after total resection of glioblastoma core lesions by surgery and aggressive post-surgical treatments, life-threatening tumors inevitably recur. A characteristic obstacle in effective treatment is high intratumoral heterogeneity, both longitudin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6451e4e10016a2a278c67cf2a29d14b9
https://doi.org/10.1101/2020.11.26.399725
https://doi.org/10.1101/2020.11.26.399725
Autor:
Soniya Bastola, Victoria L. Flanary, Riki Kawaguchi, Daisuke Yamashita, Hackney, Shinobu Yamaguchi, Ichiro Nakano, Satoshi Suehiro, Dolores Hambardzumyan, Marat S. Pavlyukov, Sonomura K, Myriam Gorospe, Takaaki Sato, Harley I. Kornblum, Saya Ozaki, Nakano Ma, David K. Crossman, Toru Kondo, Rachel Munk, Takeharu Kunieda
SummaryThe rise in aging population worldwide is increasing death from cancer, including glioblastoma. Here, we explore the impact of brain aging on glioma tumorigenesis. We find that glioblastoma in older patients and older mice displayed reduced ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886b97ed0048d05dd0d297d509b3de05
https://doi.org/10.1101/2020.10.10.334748
https://doi.org/10.1101/2020.10.10.334748
Autor:
Ichiro Nakano, Chaoxi Li, Svetlana Komarova, Saya Ozaki, Sadashib Ghosh, Soniya Bastola, Soujun Zhang, David K. Crossman, Jeffrey Skolnick, Victoria L. Flanary, Mutsuko Minata, James M. Markert, Shinobu Yamaguchi, Nicola Zamboni, Do-Hyun Nam, Davide Botta, Yeri Lee, Hai Yu, Hee Jin Cho, Daisuke Yamashita, Frances E. Lund, Xiaoxian Guo, Louis B. Nabors, Zhenglong Gu
Publikováno v:
Neuro Oncol
Victoria L. Flanary
Victoria L. Flanary
The highly infiltrative nature of glioblastoma (GBM) underscores limited response to current therapies and subsequent unfavorable clinical outcome. Despite the gross total resection of tumors located in the enhancing lesions, GBMs inevitably recur fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d595ea5612ecb21ef08f5c9d97f4b770
https://europepmc.org/articles/PMC6845742/
https://europepmc.org/articles/PMC6845742/
Autor:
Ichiro Nakano, Harley I. Kornblum, Galal A. Elsayed, Daisuke Yamashita, Gustavo Chagoya, Sung Hak Kim, Nicola Zamboni, Shinobu Yamaguchi, Victoria L. Flanary, Joshua D. Bernstock, Adeel Ilyas, Krishna P. Bhat, Dagoberto Estevez-Ordonez, James Mooney, James R. Hackney, Ahmed Mohyeldin, Hirokazu Sadahiro, E. Antonio Chiocca
Publikováno v:
J Neurosurg
OBJECTIVEDespite an aggressive multimodal therapeutic regimen, glioblastoma (GBM) continues to portend a grave prognosis, which is driven in part by tumor heterogeneity at both the molecular and cellular levels. Accordingly, herein the authors sought
Autor:
Soniya Bastola, Harley I. Kornblum, Gwendalyn D. King, Rachel Munk, Kunieda, Svetlana Komarova, Kazuhiro Sonomura, Sadashib Ghosh, Dolores Hambardzumyan, Ichiro Nakano, Riki Kawaguchi, Victoria L. Flanary, Toru Kondo, James R. Hackney, Satoshi Suehiro, Steve Horvath, Takaaki Sato, Myriam Gorospe, Saya Ozaki, Joshua D. Bernstock, Daisuke Yamashita, Zhihong Chen, Shinobu Yamaguchi, David K. Crossman
Publikováno v:
Neuro Oncol
The rise in population aging worldwide is causing an unparalleled increase in death from many cancers, including glioblastoma (GBM). Here, we have explored the impact of aging and rejuvenation on GBM tumorigenesis. Compared with neuro-inflammatory ol