Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Victoria L. Emerick"'
Autor:
Martyn Banks, Ashley M. Hine, Caitlin E. Scott, Jefferson Chin, Litao Zhang, Mike Power, Yu-Hsien Liao, Lisa M. Ogawa, Samuel Gerritz, Edward J. Hunnicutt, Craig J. Dowling, Debra A. Kendall, Neil T. Burford, Andrew Alt, Victoria L. Emerick
Publikováno v:
SLAS Discovery. 23:375-383
The endocannabinoid system (ECS) plays a diverse role in human physiology ranging from the regulation of mood and appetite to immune modulation and the response to pain. Drug development that targets the cannabinoid receptors (CB(1) and CB(2)) has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b06cf8c35b129d5cdbd5b9ad655341
https://doi.org/10.1177/2472555217748403
https://doi.org/10.1177/2472555217748403
Autor:
Victoria L. Emerick, Sarah A. Woodson
Publikováno v:
Molecular and Cellular Biology. 13:1137-1145
A highly conserved ribosomal stem-loop immediately upstream of the Tetrahymena splice junction can inhibit both forward and reverse self-splicing by competing with base pairing between the 5' exon and the guide sequence of the intervening sequence. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dcec14f035dc1ea5a073873806c015
https://doi.org/10.1128/mcb.13.2.1137
https://doi.org/10.1128/mcb.13.2.1137
In several forms of beta-thalassemia, mutations in the second intron of the beta-globin gene create aberrant 5' splice sites and activate a common cryptic 3' splice site upstream. As a result, the thalassemic beta-globin pre-mRNAs are spliced almost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65305cfa05f2bde7a8bfbb3a3ae3922
Publikováno v:
Biochemistry. 35(41)
RNA catalyzed reactions are often limited in vitro by the rate of structural rearrangements in the RNA. Analysis of intra- and intermolecular splicing of the Tetrahymena preribosomal RNA revealed two well resolved kinetic phases with rate constants o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9d4e8f5d1c5af42d5e15fce8de52a2
https://pubmed.ncbi.nlm.nih.gov/8873616
https://pubmed.ncbi.nlm.nih.gov/8873616
Autor:
Victoria L. Emerick, Sarah A. Woodson
Evidence that folding of the Tetrahymena pre-rRNA follows a defined path and is rate-determining for splicing at physiological temperatures is presented. Structural isomers were separated by native polyacrylamide gel electrophoresis and their splicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6678c76fc4c00407f22d912577d78bd9
https://europepmc.org/articles/PMC44879/
https://europepmc.org/articles/PMC44879/
Autor:
Sarah A. Woodson, Victoria L. Emerick
Publikováno v:
Biochemistry. 32(50)
RNA processing depends in part on the ability of nascent transcripts to fold into the desired conformation. Self-splicing of the group I intron from Tetrahymena was used to assess the folded state of preribosomal RNA transcripts when synthesized in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58411b7936a9615171809169d77c5f7
https://pubmed.ncbi.nlm.nih.gov/8268185
https://pubmed.ncbi.nlm.nih.gov/8268185