Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial.

Autor: Victoria K Snowdon, Neil J Lachlan, Anna M Hoy, Patrick W F Hadoke, Scott I Semple, Dilip Patel, Will Mungall, Timothy J Kendall, Adrian Thomson, Ross J Lennen, Maurits A Jansen, Carmel M Moran, Antonella Pellicoro, Prakash Ramachandran, Isaac Shaw, Rebecca L Aucott, Thomas Severin, Rajnish Saini, Judy Pak, Denise Yates, Neelesh Dongre, Jeremy S Duffield, David J Webb, John P Iredale, Peter C Hayes, Jonathan A Fallowfield

Publikováno v: PLoS Medicine, Vol 14, Iss 2, p e1002248 (2017)

BackgroundChronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow and renal function. Extreme renal vasoconstriction characterizes hepatorenal syndrome, a functional and potentially

Externí odkaz: https://doaj.org/article/ab7417500a97421588c9af8b777a3c6d

Breath Biopsy Assessment of Liver Disease Using an Exogenous Volatile Organic Compound—Toward Improved Detection of Liver Impairment

Autor: Max Allsworth, Irene Debiram-Beecham, Alexandra de Saedeleer, Matthew Hoare, Billy Boyle, Michael Allison, Megan Williams, Marzia Calcagno, Chris A. Mayhew, Robert Smith, Anita Kaur Thind, Giuseppe Ferrandino, Olga Gandelman, Isabel Orf, Anne Marie Lydon, Victoria K. Snowdon, Graham Kibble, Marc P. van der Schee

Publikováno v: Clinical and Translational Gastroenterology

INTRODUCTION: Liver cirrhosis and its complication — hepatocellular carcinoma (HCC) — have been associated with increased exhaled limonene. It is currently unclear whether this increase is more strongly associated with the presence of HCC or with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957de1719cbbbbda57750de33253171c
http://europepmc.org/articles/PMC7498135

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial

Autor: Victoria K, Snowdon, Neil J, Lachlan, Anna M, Hoy, Patrick W F, Hadoke, Scott I, Semple, Dilip, Patel, Will, Mungall, Timothy J, Kendall, Adrian, Thomson, Ross J, Lennen, Maurits A, Jansen, Carmel M, Moran, Antonella, Pellicoro, Prakash, Ramachandran, Isaac, Shaw, Rebecca L, Aucott, Thomas, Severin, Rajnish, Saini, Judy, Pak, Denise, Yates, Neelesh, Dongre, Jeremy S, Duffield, David J, Webb, John P, Iredale, Peter C, Hayes, Jonathan A, Fallowfield

Publikováno v: Snowdon, V K, Lachlan, N J, Hoy, A M, Hadoke, P W F, Semple, S I, Patel, D, Mungall, W, Kendall, T J, Thomson, A, Lennen, R J, Jansen, M A, Moran, C M, Pellicoro, A, Ramachandran, P, Shaw, I, Aucott, R L, Severin, T, Saini, R, Pak, J, Yates, D, Dongre, N, Duffield, J S, Webb, D J, Iredale, J P, Hayes, P C, Fallowfield, J A & Taal, M W (ed.) 2017, ' Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial ', PLoS Medicine, vol. 14, no. 2, e1002248 . https://doi.org/10.1371/journal.pmed.1002248
PLoS Medicine, Vol 14, Iss 2, p e1002248 (2017)
PLoS Medicine

Background Chronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow and renal function. Extreme renal vasoconstriction characterizes hepatorenal syndrome, a functional and potentiall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fd7aad772f0e5442da544546fa762fb9
https://www.pure.ed.ac.uk/ws/files/31790312/journal.pmed.1002248.pdf

Editorial:measuring inflammatory and fibrotic components of portal hypertension - a noninvasive hepatic venous pressure gradient?

Autor: Jonathan A. Fallowfield, Victoria K. Snowdon

Publikováno v: Snowdon, V K & Fallowfield, J A 2016, ' Editorial : measuring inflammatory and fibrotic components of portal hypertension-a noninvasive hepatic venous pressure gradient? ', Alimentary Pharmacology and Therapeutics, vol. 44, no. 2, pp. 204-5 . https://doi.org/10.1111/apt.13667

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad61bf1118aa5a4b2becb95ea73cde7
https://hdl.handle.net/20.500.11820/28d071d4-081b-4e12-9d13-b867c04f1556

Models and Mechanisms of Fibrosis Resolution

Autor: Victoria K. Snowdon, Jonathan A. Fallowfield

Publikováno v: Alcoholism: Clinical and Experimental Research. 35:794-799

Liver fibrosis and its end stage, cirrhosis, represent the final common pathway of virtually all chronic liver diseases. As our understanding of the pathogenesis of liver fibrosis has progressed, it has become evident that the liver provides a useful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::debda029ac473e05078a2888be5c4a48
https://doi.org/10.1111/j.1530-0277.2010.01400.x