Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Victoria K. Salb"'
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Autor:
Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Externí odkaz:
https://doaj.org/article/224be2193f454379b9efe6527272f625
Autor:
Maike Becker, Isabelle Serr, Victoria K. Salb, Verena B. Ott, Laura Mengel, Matthias Blüher, Benno Weigmann, Hans Hauner, Matthias H. Tschöp, Carolin Daniel
Publikováno v:
Molecular Metabolism, Vol 28, Iss , Pp 73-82 (2019)
Objective: Obesity and type-2 diabetes (T2D) are metabolic diseases that represent a critical health problem worldwide. Metabolic disease is differentially associated with fat distribution, while visceral white adipose tissue (VAT) is particularly pr
Externí odkaz:
https://doaj.org/article/7f983c55609542f1b139db9445e15d46
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Autor:
Anette-Gabriele Ziegler, Isabelle Serr, Adam M. Zahm, Saverio Bellusci, Katharina Gerlach, Martin G. Scherm, Victoria K. Salb, Rossella Manfredini, Benno Weigmann, Carolin Daniel, Jonathan Schug, Klaus H. Kaestner
Publikováno v:
Nat. Commun. 10:5697 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e536d3d68712489a059ba724008a1e14
https://hdl.handle.net/11380/1221487
https://hdl.handle.net/11380/1221487
Autor:
Hans Hauner, Laura A. Mengel, Verena B. Ott, Maike Becker, Isabelle Serr, Matthias Blüher, Victoria K. Salb, Carolin Daniel, Benno Weigmann, Matthias H. Tschöp
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 28, Iss, Pp 73-82 (2019)
Mol. Metab. 28, 73-82 (2019)
Molecular Metabolism, Vol 28, Iss, Pp 73-82 (2019)
Mol. Metab. 28, 73-82 (2019)
Objective Obesity and type-2 diabetes (T2D) are metabolic diseases that represent a critical health problem worldwide. Metabolic disease is differentially associated with fat distribution, while visceral white adipose tissue (VAT) is particularly pro