Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Victoria Jackson-Patel"'
Autor:
Victoria Jackson-Patel, Emily Liu, Matthew R. Bull, Amir Ashoorzadeh, Gib Bogle, Anna Wolfram, Kevin O. Hicks, Jeff B. Smaill, Adam V. Patterson
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Hypoxia-activated prodrugs are bioactivated in oxygen-deficient tumour regions and represent a novel strategy to exploit this pharmacological sanctuary for therapeutic gain. The approach relies on the selective metabolism of the prodrug under patholo
Externí odkaz:
https://doaj.org/article/c34ba5238adc4eb49a0ab52ce8b13172
Autor:
Anna E. S. Brooks, Megan Iminitoff, Eloise Williams, Tanvi Damani, Victoria Jackson-Patel, Vicky Fan, Joanna James, P. Rod Dunbar, Vaughan Feisst, Hilary M. Sheppard
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Human adipose-derived mesenchymal stromal cells (ASC) are showing clinical promise for the treatment of a range of inflammatory and degenerative conditions. These lipoaspirate-derived cells are part of the abundant and accessible source of heterogene
Externí odkaz:
https://doaj.org/article/f4b3e995b2df4404966191d1a59a9230
Autor:
Maria R. Abbattista, Amir Ashoorzadeh, Christopher P. Guise, Alexandra M. Mowday, Rituparna Mittra, Shevan Silva, Kevin O. Hicks, Matthew R. Bull, Victoria Jackson-Patel, Xiaojing Lin, Gareth A. Prosser, Neil K. Lambie, Gabi U. Dachs, David F. Ackerley, Jeff B. Smaill, Adam V. Patterson
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1231 (2021)
PR-104 is a phosphate ester pre-prodrug that is converted in vivo to its cognate alcohol, PR-104A, a latent alkylator which forms potent cytotoxins upon bioreduction. Hypoxia selectivity results from one-electron nitro reduction of PR-104A, in which
Externí odkaz:
https://doaj.org/article/b19c86e2af6c49538c7e81a3e7b91af6
Autor:
Kevin O. Hicks, Christopher P. Guise, Maria R. Abbattista, Shevan Silva, David F. Ackerley, Victoria Jackson-Patel, Alexandra M. Mowday, Matthew Bull, Gareth A. Prosser, Rituparna Mittra, Amir Ashoorzadeh, Gabi U. Dachs, Jeff B. Smaill, Neil K Lambie, Adam V. Patterson, Xiaojing Lin
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 1231, p 1231 (2021)
Pharmaceuticals; Volume 14; Issue 12; Pages: 1231
Pharmaceuticals, Vol 14, Iss 1231, p 1231 (2021)
Pharmaceuticals; Volume 14; Issue 12; Pages: 1231
PR-104 is a phosphate ester pre-prodrug that is converted in vivo to its cognate alcohol, PR-104A, a latent alkylator which forms potent cytotoxins upon bioreduction. Hypoxia selectivity results from one-electron nitro reduction of PR-104A, in which
Autor:
Arthur Jochems, Jeff B. Smaill, Christopher P. Guise, Arne Heyerick, Maria R. Abbattista, Sophie Thiolloy, Amir Ashoorzadeh, Alexander M A van der Wiel, Kevin O. Hicks, Jan Theys, Ludwig Dubois, Philippe Lambin, Xiaojing Lin, Emily Liu, Robert F. Anderson, Zhe Fu, Damiënne Marcus, Victoria Jackson-Patel, Adam V. Patterson, Sisira Kumara, Ala Yaromina, Matthew Bull, Silvia Balbo, Morwena J. Solivio, R. Biemans, Sofie Deschoemaeker, Raymon Niemans, Alexandra M. Mowday, Natasja G. Lieuwes
Publikováno v:
Molecular Cancer Therapeutics, 20(12), 2372-2383. American Association for Cancer Research Inc.
Background Hypoxia-activated prodrugs (HAPs) are a promising class of antineoplastic agents that can selectively eliminate hypoxic tumor cells. The present study evaluates the hypoxia-selectivity and antitumor activity of CP-506, a DNA alkylating HAP
Autor:
Michelle Locke, Kerry M. Loomes, P. Rod Dunbar, Vaughan Feisst, Pritika Narayan, Jennifer Eom, Victoria Jackson-Patel, Hilary M. Sheppard, Louis Ranjard, Tanvi Damani
Publikováno v:
Journal of Visualized Experiments : JoVE
Several dyes are currently available for use in detecting differentiation of mesenchymal cells into adipocytes. Dyes, such as Oil Red O, are cheap, easy to use and widely utilized by laboratories analyzing the adipogenic potential of mesenchymal cell