Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Victoria J. Philbin"'
Autor:
Sarah Burl, John Townend, Jainaba Njie-Jobe, Momodou Cox, Uche J Adetifa, Ebrima Touray, Victoria J Philbin, Christy Mancuso, Beate Kampmann, Hilton Whittle, Assan Jaye, Katie L Flanagan, Ofer Levy
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18185 (2011)
The global burden of neonatal and infant mortality due to infection is staggering, particularly in resource-poor settings. Early childhood vaccination is one of the major interventions that can reduce this burden, but there are specific limitations t
Externí odkaz:
https://doaj.org/article/4549473818f14fcbae731ca87cf45b13
Autor:
Katheryn Nathe, Linda J. Van Marter, Liat Stoler-Barak, Victoria J. Philbin, Christine D. Palmer, Richard B. Parad, Michele Phillips, Christy J. Mancuso, Ofer Levy, Camilia R. Martin
Publikováno v:
Pediatric Research
Background: Tracheal aspirates (TAs) from critically ill neonates accumulate bacterial endotoxin and demonstrate mobilization of endotoxin-binding proteins, but the potential bioactivity of endotoxin in TAs is unknown. We characterized innate immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e3270abd4adb636cad87732554769f
https://doi.org/10.1038/pr.2012.61
https://doi.org/10.1038/pr.2012.61
Autor:
Ofer Levy, Victoria J. Philbin
Publikováno v:
Pediatric Research. 65:98R-105R
Molecular characterization of mechanisms by which human pattern recognition receptors (PRRs) detect danger signals has greatly expanded our understanding of the innate immune system. PRRs include Toll-like receptors (TLRs), nucleotide oligomerization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b436664293f9625976413644bdb4a4d
https://doi.org/10.1203/pdr.0b013e31819f195d
https://doi.org/10.1203/pdr.0b013e31819f195d
Autor:
Marianne Goodchild, Muhammad Iqbal, Duncan J. Maskell, Richard K. Beal, Yvonne Boyd, Nat Bumstead, Paul Wigley, John J. Young, Victoria J. Philbin, Adrian Smith, G. S. K. Withanage, Paul A. Barrow, Ian McConnell
Publikováno v:
Infection and Immunity. 73:2344-2350
Toll-like receptors (TLRs) are a major component of the pattern recognition receptor repertoire that detect invading microorganisms and direct the vertebrate immune system to eliminate infection. In chickens, the differential biology of Salmonella se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7816db791e1745f746c0d30a418a27a2
https://doi.org/10.1128/iai.73.4.2344-2350.2005
https://doi.org/10.1128/iai.73.4.2344-2350.2005
Publikováno v:
Veterinary Immunology and Immunopathology. 104:117-127
The Toll-like receptor (TLR) family of cell surface molecules represent a major component of the pattern recognition system, which enables both vertebrates and invertebrates to detect invading microorganisms and mount an anti-microbial response. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa364b9262732164af94de1a242964a4
https://doi.org/10.1016/j.vetimm.2004.11.003
https://doi.org/10.1016/j.vetimm.2004.11.003
Autor:
Muhammad Iqbal, Adrian Smith, Peter K. Kaiser, Victoria J. Philbin, Haiqi He, Michael H. Kogut
Publikováno v:
Developmental & Comparative Immunology. 29:791-807
The heterophil is the major polymorphonuclear cell in birds with a functional capacity akin to that of the mammalian neutrophil. Herein, we demonstrate that heterophils constitutively express TLR1/6/10, TLR2 type 1, TLR2 type 2, TLR3, TLR4, TLR5, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20033881af131371a13d06c40a68e9f2
https://doi.org/10.1016/j.dci.2005.02.002
https://doi.org/10.1016/j.dci.2005.02.002
Autor:
Dorota A. Doherty, Victoria J. Philbin, David Burgner, Tobias Strunk, Karen Simmer, Ofer Levy, Andrew J. Currie, Peter Richmond, Adrian Charles, Amy Prosser
Publikováno v:
Pediatric research. 72(1)
Staphylococcus epidermidis (SE) rarely causes infection in term infants but is a leading cause of late-onset sepsis in preterm infants. We hypothesized that the innate immune responses to SE in preterm infants are impaired in a gestational age (GA)-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24029b30a052704a64318f91b0bb0f9
https://pubmed.ncbi.nlm.nih.gov/22460219
https://pubmed.ncbi.nlm.nih.gov/22460219
Autor:
Christy J. Mancuso, Ofer Levy, Jainaba Njie-Jobe, Katie L. Flanagan, Victoria J. Philbin, Ebrima S. Touray, Beate Kampmann, John Townend, Sarah Burl, Uche J. Adetifa, Assan Jaye, Hilton Whittle, Momodou Cox
Publikováno v:
e18185
PLoS ONE, Vol 6, Iss 4, p e18185 (2011)
PLoS ONE
PLoS ONE, Vol 6, Iss 4, p e18185 (2011)
PLoS ONE
The global burden of neonatal and infant mortality due to infection is staggering, particularly in resource-poor settings. Early childhood vaccination is one of the major interventions that can reduce this burden, but there are specific limitations t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d031aff6779c0778144fd46a6e0ff382
http://ora.ox.ac.uk/objects/uuid:2986b3b8-b70c-42db-b633-c308fb525433
http://ora.ox.ac.uk/objects/uuid:2986b3b8-b70c-42db-b633-c308fb525433
Autor:
Victoria J. Philbin, Ofer Levy
Publikováno v:
Biochemical Society transactions. 35(Pt 6)
TLR8 (Toll-like receptor 8) is activated by ssRNAs (single-stranded RNAs) and synthetic imidazoquinoline compounds that resemble purines and have immunostimulatory activity. TLR8 agonists are particularly effective at inducing Th1-polarizing response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b23e324e56deb27fdad6d3eaab6c91
https://pubmed.ncbi.nlm.nih.gov/18031250
https://pubmed.ncbi.nlm.nih.gov/18031250
Autor:
Yvonne Boyd, Adrian Smith, Victoria J. Philbin, Marianne Goodchild, Richard K. Beal, Nat Bumstead, Muhammad Iqbal, John J. Young
Publikováno v:
Immunology. 114(4)
Based upon the recognition of antiviral compounds and single stranded viral RNA the Toll-like receptors TLR7 and TLR8 are suggested to play a significant role in initiating antiviral immune responses. Here we report the molecular characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a0bf269be50c93aabb5a02cd9a7a15
https://pubmed.ncbi.nlm.nih.gov/15804288
https://pubmed.ncbi.nlm.nih.gov/15804288