Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Victoria J. Gennaro"'
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical deter
Externí odkaz:
https://doaj.org/article/6b22ccd228454ba2acf8e16bbd46492c
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
BMC Cancer
BMC Cancer
Background The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fde64a2be0fe1220bc42d324e2e46a0
http://link.springer.com/article/10.1186/s12885-019-5454-2
http://link.springer.com/article/10.1186/s12885-019-5454-2
Autor:
Karen E. Knudsen, Christopher McNair, Victoria J. Gennaro, Mason A Tracewell, Kristen L. Pauley, Daniela Di Marcantonio, Sabrina Butt, Timothy J. Stanek, Stephen M. Sykes, Tauseef R. Butt, Andrew V. Kossenkov, Feng Wang, Steven B. McMahon
Publikováno v:
The EMBO Journal
The SAGA coactivator complex is essential for eukaryotic transcription and comprises four distinct modules, one of which contains the ubiquitin hydrolase USP22. In yeast, the USP22 ortholog deubiquitylates H2B, resulting in Pol II Ser2 phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8096358d53d59aa93315c12282468d86
https://pubmed.ncbi.nlm.nih.gov/34155658
https://pubmed.ncbi.nlm.nih.gov/34155658
Autor:
Nilesh Chitnis, Kent Armeson, Constantinos Koumenis, Gerald Wertheim, Yiwen Bu, J. Alan Diehl, Akihiro Yoshida, Chi V. Dang, Amanda R. Oran, Feven Tameire, Davide Ruggero, Serge Y. Fuchs, Victoria J. Gennaro, Brian J. Altman, Steven B. McMahon
Publikováno v:
Nature Cell Biology. 20:104-115
The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024d7a1a271fb25e22add9e84ce743a6
https://doi.org/10.1038/s41556-017-0006-y
https://doi.org/10.1038/s41556-017-0006-y
Autor:
Clare M. Adams, Hans E. Seidel, Jordan Kaplan, Isidore Rigoutsos, Chen Shen, Steven B. McMahon, Christopher R. Vakoc, Lewis A. Chodosh, Harla K. Pfeiffer, James E. Bradner, Jamie J. Arnold, Michael P. King, Craig E. Cameron, Ubaldo E. Martinez-Outschoorn, James E. Thompson, Gerald S. Shadel, Suresh D. Sharma, Kirsten Mascioli, Mahmoud R. Gaballa, Amanda R. Oran, Justin Cotney, Hestia S. Mellert, Xiao-yong Zhang, Victoria J. Gennaro, Christine M. Eischen
Publikováno v:
Oncotarget
// Amanda R. Oran 1 , Clare M. Adams 1 , Xiao-yong Zhang 1 , Victoria J. Gennaro 1 , Harla K. Pfeiffer 1 , Hestia S. Mellert 2 , Hans E. Seidel 3 , Kirsten Mascioli 1 , Jordan Kaplan 1 , Mahmoud R. Gaballa 1 , Chen Shen 4,5 , Isidore Rigoutsos 1 , Mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c65393723e04e992085dc311a59a0a
https://doi.org/10.18632/oncotarget.11718
https://doi.org/10.18632/oncotarget.11718
Autor:
Timothy J. Stanek, Victoria J. Gennaro, Amy R. Peck, Hallgeir Rui, Yunguang Sun, Karen E. Knudsen, Feng Wang, Steven B. McMahon, Shuo Qie, Tauseef R. Butt, J. Alan Diehl
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The deubiquitylase USP22 is frequently overexpressed in cancer and contributes to tumorigenesis by driving cell cycle progression. Current models define USP22 as functional mediator of gene regulation and chromatin modification, working
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bc2709e9e8b43e586253740e365afd
https://doi.org/10.1073/pnas.1807704115
https://doi.org/10.1073/pnas.1807704115
Autor:
Angelo C. Lepore, Davide Trotti, Victoria J. Gennaro, Michael R. Jablonski, Piera Pasinelli, Ke Li, Ni J. Meng, Shashirekha S. Markandaiah, Dena Jacob
Publikováno v:
Annals of Clinical and Translational Neurology
The limited progress in identifying successful therapies in Amyotrophic Lateral Sclerosis (ALS) has only resulted in one moderately effective pharmacological agent, riluzole.1,2 In research on the SOD1-G93A mouse model of ALS, riluzole showed a modes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01350cf5b132f59551434380555df95c
https://doi.org/10.1002/acn3.141
https://doi.org/10.1002/acn3.141
Autor:
Karen E. Knudsen, Timothy J. Stanek, Sabrina Butt, Christopher McNair, Steven B. McMahon, Victoria J. Gennaro, Kristen L. Pauley
Publikováno v:
Molecular Cancer Therapeutics. 17:LB-A29
SAGA is a 2 MDa multi-subunit complex containing two assembly modules (TAF and SPT) and two enzymatic modules (HAT and DUB) which exhibit acetyltransferase activity via GCN5 and deubiquitylase activity via USP22. Multiple studies in yeast, flies, mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e26b47d8c8f9f3bd3f6551115f6c6d3c
https://doi.org/10.1158/1535-7163.targ-17-lb-a29
https://doi.org/10.1158/1535-7163.targ-17-lb-a29
Autor:
Andrei Thomas-Tikhonenko, Xiao-yong Zhang, Duonan Yu, Victoria J. Gennaro, Lauren DeSalle, Steven B. McMahon, Christopher R. Vakoc
Publikováno v:
Cancer Research. 76:4553-4553
Pathological activation of the transcription factor Myc induces a multitude of human malignancies. In Myc-driven tumor progression, there is a robust dependence on Myc activity; however, strategies developed to explicitly modulate Myc function in can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe806f9519ee5fe5213db08f380148b1
https://doi.org/10.1158/1538-7445.am2016-4553
https://doi.org/10.1158/1538-7445.am2016-4553
Autor:
Gerald S. Shadel, Craig E. Cameron, Xiao-yong Zhang, Clare Adams, Steven B. McMahon, Victoria J. Gennaro, Christine M. Eischen, Amanda Taylor, Justin Cotney
Publikováno v:
Cancer Research. 76:1256-1256
The MYC transcription factor is the most dramatically overexpressed gene product in human cancer. However, defining the MYC-driven transcriptome critical to malignant transformation has remained a challenge, in part because MYC controls several thous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dee7f531a5eeae9d66d16977c3f0edf7
https://doi.org/10.1158/1538-7445.am2016-1256
https://doi.org/10.1158/1538-7445.am2016-1256