Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Victoria J. Bolton"'
Autor:
Alison I. Muir, Izzy Boyfield, Kalindi Vaidya, Barry Sidney Orlek, Etienne Fleury, David G. Evans, Jackie S. Scott, Hindy Mok, Victoria J. Bolton, Ward John Gerard, Geoffrey Stemp, Tom D. Heightman, Kim L. Matthews, Kirk Lawless, Gareth J. Sanger, Fiona McKay, Alexander J. Stevens, Emma M. Jarvie, James Matthew Bailey, Susan Marie Westaway, Mervyn Thompson, Jonathan B. Basilla
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6452-6458
Optimisation of a series of benzazepine sulfonamide hit compounds identified from high throughput screening led to the discovery of a new series of tractable, potent motilin receptor agonists.
Autor:
G Bruton, C M Taylor, Anna K. Bassil, Scott G. Summerfield, Kevin Lee, Victoria J. Bolton, Gareth J. Sanger, Wendy J. Winchester, Jason D. Brown, Leanne Cutler, Karen M. Gray
Publikováno v:
British Journal of Pharmacology. 158:252-258
Background: 5-HT2B receptors are localized within the myenteric nervous system, but their functions on motor/sensory neurons are unclear. To explore the role of these receptors, we further characterized the 5-HT2B receptor antagonist RS-127445 and st
Autor:
Jonathan M. Barford, Victoria J. Bolton, Geoffrey Stemp, Shiyam Mohamed, Stephen Christopher Martin Fell, Christopher N. Johnson, Gareth J. Sanger, David MacPherson, Samantha Louisa Brown, Chermaine Cluff, Darren Jason Mitchell, Sadhia R. Mahmood, Fiona McKay, Beverley Smith, Jon T. Seal, James Myatt, Alison I. Muir, Mervyn Thompson, Kim L. Matthews, Kirk Lawless, Steven J. Stanway, Emma M. Jarvie, Alexander J. Stevens, Susan Marie Westaway
Publikováno v:
Journal of medicinal chemistry. 52(4)
N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine 12 (GSK962040) is a novel small molecule motilin receptor agonist. It possesses excellent activity at the recombinant human motilin receptor and also at the
Autor:
Andrea Colombo, Izzy Boyfield, Christopher N. Johnson, Alessandra Consonni, Emma M. Jarvie, Victoria J. Bolton, Darren Jason Mitchell, Paolo Celestini, Michael A. Briggs, Sharon C Stratton, James Myatt, Geoffrey Stemp, David MacPherson, Alexander J. Stevens, Jon T. Seal, Stefania Gagliardi, Steven J. Stanway, Macdonald Gregor James, Mauro Riccaboni, Kate Lapsley, Susan Marie Westaway, Silvano Ronzoni, Gareth J. Sanger, Tom D. Heightman, Kim L. Matthews, Samantha Louisa Brown, Mervyn Thompson, Elizabeth Conway
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(24)
Optimisation of urea (5), identified from high throughput screening and subsequent array chemistry, has resulted in the identification of pyridine carboxamide (33) which is a potent motilin receptor agonist possessing favourable physicochemical and A
Autor:
Anna K. Bassil, Wendy J. Winchester, Karen M. Gray, Victoria J. Bolton, Gareth J. Sanger, Colleen M. Taylor, Kevin A.W. Lee
Publikováno v:
Gastroenterology. 134:A-543