Vδ2 T-cell engagers bivalent for Vδ2-TCR binding provide anti-tumor immunity and support robust Vγ9Vδ2 T-cell expansion

Autor: Lisa A. King, Milon de Jong, Myrthe Veth, David Lutje Hulsik, Parsa Yousefi, Victoria Iglesias-Guimarais, Pauline M. van Helden, Tanja D. de Gruijl, Hans J. van der Vliet

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundVγ9Vδ2 T-cells are antitumor immune effector cells that can detect metabolic dysregulation in cancer cells through phosphoantigen-induced conformational changes in the butyrophilin (BTN) 2A1/3A1 complex. In order to clinically exploit the

Externí odkaz: https://doaj.org/article/3eb04d8fffbe403ba273566ef54bbcbc

Estudio médico-forense de la muerte bajo custodia durante el terrorismo de Estado en Uruguay

Autor: Hugo Rodríguez Almada, Natalia Bazán Hernández, Victoria Iglesias Salaverría, Evangelina Pérez Real

Publikováno v: Revista Médica del Uruguay, Vol 38, Iss 2 (2022)

Toda muerte bajo custodia es potencialmente ilícita por acción u omisión del Estado. Se presenta el reporte sistematizado desde la perspectiva forense de la muerte bajo custodia en la prisión política en Uruguay durante el terrorismo de Estado.

Externí odkaz: https://doaj.org/article/0479a259a23849dfadaa5ea34aac6bc5

Data from Radiotherapy and Cisplatin Increase Immunotherapy Efficacy by Enabling Local and Systemic Intratumoral T-cell Activity

Autor: Inge Verbrugge, Jannie Borst, Marcel Verheij, Ton N. Schumacher, Marit M. van Buuren, Andriy Volkov, Victoria Iglesias-Guimarais, Elselien Frijlink, Paula Kroon

To increase cancer immunotherapy success, PD-1 blockade must be combined with rationally selected treatments. Here, we examined, in a poorly immunogenic mouse breast cancer model, the potential of antibody-based immunomodulation and conventional anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92ea48ddcb7cc40245f8b7be500ac89
https://doi.org/10.1158/2326-6066.c.6550047.v1

Figure S1 - S7 from Subcellular Localization of Antigen in Keratinocytes Dictates Delivery of CD4+ T-cell Help for the CTL Response upon Therapeutic DNA Vaccination into the Skin

Autor: Adriaan D. Bins, Jannie Borst, Matthew F. Krummel, Tomasz Ahrends, Victoria Iglesias-Guimarais, Evert de Vries, Astrid Bovens, Nikolina Bąbała

Supplemental Figures and Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8441bb37cb3a9d86c9c8d84650ead2c2
https://doi.org/10.1158/2326-6066.22539103.v1

A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies

Autor: Roeland Lameris, Jurjen M. Ruben, Victoria Iglesias-Guimarais, Milon de Jong, Myrthe Veth, Fleur S. van de Bovenkamp, Iris de Weerdt, Arnon P. Kater, Sonja Zweegman, Sjeng Horbach, Thilo Riedl, Benjamin Winograd, Rob C. Roovers, Anton E.P. Adang, Tanja D. de Gruijl, Paul W.H.I. Parren, Hans J. van der Vliet

Publikováno v: Lameris, R, Ruben, J M, Iglesias-Guimarais, V, de Jong, M, Veth, M, van de Bovenkamp, F S, de Weerdt, I, Kater, A P, Zweegman, S, Horbach, S, Riedl, T, Winograd, B, Roovers, R C, Adang, A E P, de Gruijl, T D, Parren, P W H I & van der Vliet, H J 2023, ' A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies ', Cell Reports Medicine, vol. 4, no. 3, 100961 . https://doi.org/10.1016/j.xcrm.2023.100961
Cell Reports Medicine, 4(3):100961. Cell Press

Bispecific T cell engagers (bsTCEs) hold great promise for cancer treatment but face challenges due to the induction of cytokine release syndrome (CRS), on-target off-tumor toxicity, and the engagement of immunosuppressive regulatory T cells that lim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f5da61cacb0846af50c264921831b1
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