Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Victoria H Gilchrist"'
Autor:
Huy-Dung Hoang, Aida Said, Nasana Vaidya, Victoria H Gilchrist, Kyle Malone, Usha Kabilan, Serena Topshee, Xiao Xiang, An-Dao Yang, David Olagnier, Karen Mossman, Shawn T Beug, Seyed Mehdi Jafarnejad, Samuel T Workenhe, Tyson E Graber, Tommy Alain
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, com
Externí odkaz:
https://doaj.org/article/a6f957f1406d4b8b8ac61e2d28561a27
Autor:
Xiao Xiang, Huy-Dung Hoang, Victoria H. Gilchrist, Stéphanie Langlois, Tommy Alain, Kyle N. Cowan
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-15 (2022)
Abstract Rhabdomyosarcoma (RMS) is a deadly cancer of skeletal muscle origin. Pannexin 1 (PANX1) is down-regulated in RMS and increasing its levels drastically inhibits RMS progression. PANX1 upregulation thus represents a prospective new treatment s
Externí odkaz:
https://doaj.org/article/41fb1fb1994e45e6919f3b7ece5e8a26
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inf
Externí odkaz:
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
Autor:
Huy-Dung Hoang, Tyson E. Graber, Jian-Jun Jia, Nasana Vaidya, Victoria H. Gilchrist, Xiao Xiang, Wencheng Li, Kyle N. Cowan, Christos G. Gkogkas, Maritza Jaramillo, Seyed Mehdi Jafarnejad, Tommy Alain
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4010-4023.e5 (2019)
Summary: Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. Translational control of mRNA is an important feature of innate immunity, yet the identity of translationally regulated mRNAs functioning in ho
Externí odkaz:
https://doaj.org/article/d0ba72a6fd26432394fca51a4c7a5ad3
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/7a767ab0a50943a0a5a6e85eaa10ccfe
Autor:
Christian K. Holm, Anne L. Thielke, Rasmus Ottosen, Thomas B. Poulsen, Jinrong Huang, Alice Knudsen, Lydia Bartsch, Siddharth Balachandran, Marie B. Iversen, Camilla G. Nielsen, Victoria H. Gilchrist, Trine H. Mogensen, Huy-Dung Hoang, Alon Schneider Hait, Sofie E. Jørgensen, Line S. Reinert, Suraj Peri, Jan Rehwinkel, Michael Lappe, Charlotte Möller, Michelle M. Thomsen, John Hiscott, Demi van der Horst, Esben B. Svenningsen, Anne Louise Hansen, Yonglun Luo, Jacob Thyrsted, Manja Idorn, Antonio Alcami, Ensieh Farahani, Julia Blay-Cadanet, Martin R. Jakobsen, Bruno Hernáez, Mirjam Schilling, David Olagnier, Søren R. Paludan, Angela Herengt, Tommy Alain
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Olagnier, D, Farahani, E, Thyrsted, J, Blay-Cadanet, J, Herengt, A, Idorn, M, Hait, A, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M, Reinert, L S, Lappe, M, Hoang, H-D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, no. 1, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Olagnier, D P C, Farahani, E, Jensen, J T, Blay Cadanet, J, Herengt, A A P V, Idorn, M, Schneider Hait, A I, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M M, Reinert, L S, Lappe, M, Hoang, H D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Olagnier, D, Farahani, E, Thyrsted, J, Blay-Cadanet, J, Herengt, A, Idorn, M, Hait, A, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M, Reinert, L S, Lappe, M, Hoang, H-D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, no. 1, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Olagnier, D P C, Farahani, E, Jensen, J T, Blay Cadanet, J, Herengt, A A P V, Idorn, M, Schneider Hait, A I, Hernaez, B, Knudsen, A, Iversen, M B, Schilling, M, Jørgensen, S E, Thomsen, M M, Reinert, L S, Lappe, M, Hoang, H D, Gilchrist, V H, Hansen, A L, Ottosen, R, Nielsen, C G, Møller, C, van der Horst, D, Peri, S, Balachandran, S, Huang, J, Jakobsen, M, Svenningsen, E B, Poulsen, T B, Bartsch, L, Thielke, A L, Luo, Y, Alain, T, Rehwinkel, J, Alcamí, A, Hiscott, J, Mogensen, T H, Paludan, S R & Holm, C K 2020, ' SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ', Nature Communications, vol. 11, 4938 . https://doi.org/10.1038/s41467-020-18764-3
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Versiones preprint disponibles en: http://hdl.handle.net/10261/216920 y http://hdl.handle.net/10261/217161
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 ar
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c770a0f99e983608245ee2ef5c88b25
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
Autor:
Xiao Xiang, Huy-Dung Hoang, Victoria H. Gilchrist, Stéphanie Langlois, Tommy Alain, Kyle N. Cowan
Publikováno v:
Oncogenesis. 11(1)
Rhabdomyosarcoma (RMS) is a deadly cancer of skeletal muscle origin. Pannexin 1 (PANX1) is down-regulated in RMS and increasing its levels drastically inhibits RMS progression. PANX1 upregulation thus represents a prospective new treatment strategy f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4d5129a62f9fcd08c0542797af28c9
https://pubmed.ncbi.nlm.nih.gov/35194046
https://pubmed.ncbi.nlm.nih.gov/35194046
Autor:
Jinrong Huang, Demi van der Horst, Lydia Bartsch, Marie B. Iversen, Line S. Reinert, Camilla Gunderstofte, Esben B. Svenningsen, Anne Louise Hansen, Anne L. Thielke, Tommy Alain, Bruno Hernáez, Huy-Dung Hoang, John Hiscott, Thomas B. Poulsen, Charlotte Möller, Julia Blay Cadanet, Sofie E. Jørgensen, Christian K. Holm, Michael Lappe, Alon Schneider Hait, Jan Rehwinkel, Yonglun Luo, Jacob Thyrsted, Martin R. Jakobsen, Rasmus Ottosen, Michelle M. Thomsen, Søren R. Paludan, Manja Idorn, Antonio Alcami, Suraj Peri, Ensieh Farahani, Angela Herengt, Mirjam Schilling, David Olagnier, Trine H. Mogensen, Alice Knudsen, Siddharth Balachandran, Victoria H. Gilchrist
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here we demonstrate that the NRF2 anti-oxidant gene expression pathway is suppressed in bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78d0c8a4ddfb8c2f90f5fcc79fbd2a4
https://doi.org/10.1101/2020.07.16.206458
https://doi.org/10.1101/2020.07.16.206458
Publikováno v:
Cytokinegrowth factor reviews. 56
There are more than 500 kinases in the human genome, many of which are oncogenic once constitutively activated. Fortunately, numerous hyperactive kinases are druggable, and several targeted small molecule kinase inhibitors have demonstrated impressiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa11902e0b1a9a5cff5ede3c9b2ea4a5
https://pubmed.ncbi.nlm.nih.gov/32690442
https://pubmed.ncbi.nlm.nih.gov/32690442
Autor:
Tommy Alain, Seyed Mehdi Jafarnejad, Maritza Jaramillo, Victoria H. Gilchrist, Huy-Dung Hoang, Jian-Jun Jia, Wencheng Li, Tyson E. Graber, Nasana Vaidya, Christos G. Gkogkas
Publikováno v:
SSRN Electronic Journal.
Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. mRNA translation is an important component of innate immunity, yet the targeted cellular mRNAs remain ill-defined. We characterized the translatome of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70afad57aa17d8a9c6dc0936e69595c4
https://doi.org/10.2139/ssrn.3420832
https://doi.org/10.2139/ssrn.3420832