Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Victoria Fairchild-Huntress"'
Autor:
Dennis Huszar, Victoria Fairchild-Huntress, Qing Fang, Judy H. Dunmore, James R. Tonra, Gary X. Yu, Hong Zhou, Yanming F. Wang, Lakshmi S. Amaravadi, Yang Pan, Sulpicio G. Soriano
Publikováno v:
Journal of Neuroimmunology. 125:59-65
Fractalkine (FKN), also known as neurotactin, is a CX(3)C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to
Autor:
Victoria Fairchild-Huntress, Judy H. Dunmore, Dennis Huszar, Qing Fang, Wojtek Auerbach, Anna Auerbach, Alexandra L. Joyner
Publikováno v:
BioTechniques. 29:1024-1032
Hundreds of new mutant mouse lines are being produced annually using gene targeting and gene trap approaches in embryonic stem (ES) cells, and the number is expected to continue to grow as the human and mouse genome projects progress. The availabilit
Autor:
Rosana Kapeller, Olga Charlat, Troy Chickering, Judy H. Dunmore, Dennis Huszar, James Deeds, Catherine A. Lynch, Qing Fang, Patrick W. Kleyn, Victoria Fairchild-Huntress, Hilde Stubdal, Ann Moriarty
Publikováno v:
Molecular and Cellular Biology. 20:878-882
The mouse tubby phenotype is characterized by maturity-onset obesity accompanied by retinal and cochlear degeneration. A positional cloning effort to find the gene responsible for this phenotype led to the identification of tub, a member of a novel g
Autor:
Katherine M. Galvin, Victoria Fairchild-Huntress, Dean A. Falb, Judy H. Dunmore, John N. Lorenz, Michael J. Donovan, Michael A. Gimbrone, Kristen L. Dixon, Dennis Huszar, Richard J. Paul, Catherine A. Lynch, Ronald Meyer
Publikováno v:
Nature Genetics. 24:171-174
Smad proteins are intracellular mediators of signalling initiated by Tgf-betasuperfamily ligands (Tgf-betas, activins and bone morphogenetic proteins (Bmps)). Smads 1, 2, 3, 5 and 8 are activated upon phosphorylation by specific type I receptors, and
Autor:
Richard J. Deckelbaum, Dennis Huszar, Toru Seo, Takeshi Arai, Lee Varban, Victoria Fairchild-Huntress, F. Rinninger, Alan R. Tall, Wengen Chen, Chien-Ping Liang
Publikováno v:
Proceedings of the National Academy of Sciences. 96:12050-12055
Scavenger receptor BI (SR-BI) mediates the selective uptake of high density lipoprotein (HDL) cholesteryl esters (CE) by cells, i.e., the uptake of CE without degradation of HDL protein. Mice with attenuated expression of SR-BI, because of targeted g
Autor:
Roger D. Cone, Judy H. Dunmore, Dennis Huszar, Robert A. Kesterson, Lucy R Berkemeier, Catherine A. Lynch, Wei Gu, Paul Burn, Victoria Fairchild-Huntress, Frank W. Lee, Françoise J. Smith, Bruce A. Boston, L. Arthur Campfield, Qing Fang
Publikováno v:
Cell. 88:131-141
The melanocortin-4 receptor (MC4-R) is a G protein–coupled, seven-transmembrane receptor expressed in the brain. Inactivation of this receptor by gene targeting results in mice that develop a maturity onset obesity syndrome associated with hyperpha
Autor:
Paul Hales, Nancy E. Stagliano, Colin T. Maguire, Jian Xu, Roger E. Breitbart, Vivek J. Kadambi, Charles I. Berul, Victoria Fairchild-Huntress, Mary Donoghue, John N. Lorenz, Hiroko Wakimoto, Susan L. Acton
Publikováno v:
Journal of molecular and cellular cardiology. 35(9)
Angiotensin converting enzyme related carboxypeptidase (ACE2) is a recently discovered homolog of angiotensin converting enzyme with tissue-restricted expression, including heart, and the capacity to cleave angiotensin peptides. We tested the hypothe
Autor:
Michael J. Donovan, Mariet Lee Varban, Dennis Huszar, Takeshi Arai, Victoria Fairchild-Huntress, Alan R. Tall, F. Rinninger, Roslyn Feeley
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 20(4)
Abstract —Scavenger receptor BI (SR-BI) is a multiligand cell-surface receptor that plays a central role in high density lipoprotein homeostasis in rodents. To investigate a role for SR-BI in atherosclerosis, mice with attenuated SR-BI expression w
Autor:
Chris Ebeling, Elizabeth A. Woolf, Dennis Huszar, Deborah L. Nagle, Sonja H. McGrail, Karen J. Moore, Barry J. Dussault, Paul Burn, Victoria Fairchild-Huntress, George A. Carlson, Peer Bork, Lisa DiRocco, Pei Ge, Jill Montagno, James Vitale, Lisa Holmgren, Linda Baldini, Julie Gilchrist, John Keilty
Publikováno v:
Nature. 398(6723)
Genetic studies have shown that mutations within the mahogany locus suppress the pleiotropic phenotypes, including obesity, of the agouti-lethal-yellow mutant. Here we identify the mahogany gene and its product; this study, to our knowledge, represen