Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Victoria E B Hipolito"'
Autor:
Victoria E B Hipolito, Jacqueline A Diaz, Kristofferson V Tandoc, Christian Oertlin, Johannes Ristau, Neha Chauhan, Amra Saric, Shannon Mclaughlan, Ola Larsson, Ivan Topisirovic, Roberto J Botelho
Publikováno v:
PLoS Biology, Vol 17, Iss 12, p e3000535 (2019)
The mechanisms that govern organelle adaptation and remodelling remain poorly defined. The endo-lysosomal system degrades cargo from various routes, including endocytosis, phagocytosis, and autophagy. For phagocytes, endosomes and lysosomes (endo-lys
Externí odkaz:
https://doaj.org/article/f9af41199bcf4e5b85ff1f3c2ec9827e
Autor:
Jason G. Kay, Roberto J. Botelho, Johnathan Canton, Costin N. Antonescu, Victoria E. B. Hipolito, Amra Saric
Publikováno v:
Molecular Biology of the Cell
LPS causes lysosome tubulation in macrophages and dendritic cells. The PI3K-Akt-mTOR pathway is necessary for LPS-induced lysosome tubulation, and mTOR is required for MHC-II presentation in dendritic cells. Evidence shows that mTOR may control lysos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f7bdf7548fafc61622fc8b8611f6ad
https://doi.org/10.32920/21982886.v1
https://doi.org/10.32920/21982886.v1
Autor:
Akriti Prashar, Victoria E. B. Hipolito, Roberto J. Botelho, Mauricio R. Terebiznik, Suriakarthiga Ganesan, Amriya Naufer, Vanina Zaremberg
Publikováno v:
The Journal of Cell Biology
Specific changes in phospholipid content are a hallmark of the membranes of maturing endosomes and phagosomes, but is it unclear how this is controlled. Naufer et al. now show that acidification of the lumen of endosomes and phagosomes triggers disso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697a725f5ecb13cfd0da0ad739d1185c
https://doi.org/10.32920/21982907
https://doi.org/10.32920/21982907
Autor:
Teodor E, Yordanov, Victoria E B, Hipolito, Gudrun, Liebscher, Georg F, Vogel, Taras, Stasyk, Caroline, Herrmann, Stephan, Geley, David, Teis, Roberto J, Botelho, Michael W, Hess, Lukas A, Huber
Publikováno v:
Traffic (Copenhagen, Denmark)
Mechanisms that control lysosomal function are essential for cellular homeostasis. Lysosomes adapt in size and number to cellular needs but little is known about the underlying molecular mechanism. We demonstrate that the late endosomal/lysosomal mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ef3902d0f98cd2eac241dc310124558
https://pubmed.ncbi.nlm.nih.gov/31314175
https://pubmed.ncbi.nlm.nih.gov/31314175
Autor:
Hye Kyoung Sung, Gary Sweeney, Victoria E. B. Hipolito, Roberto J. Botelho, Rengasamy Palanivel, Erfei Song, James Won Suk Jahng, Ryan C. Russell, Reham M. Alsaadi
Publikováno v:
EMBO Rep
Iron overload, a common clinical occurrence, is implicated in the metabolic syndrome although the contributing pathophysiological mechanisms are not fully defined. We show that prolonged iron overload results in an autophagy defect associated with ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a025b548ffc40f603d2b676022d60eb
https://pubmed.ncbi.nlm.nih.gov/31441223
https://pubmed.ncbi.nlm.nih.gov/31441223
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 97(4)
Lysophosphatidic acid (LPA) is a small signaling phospholipid that mediates diverse functions including cell proliferation, migration, and survival by engaging LPA-agonized G-protein coupled receptors. Autophagy is a survival mechanism in response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9205b9bc5bf84c67516b33218406f936
https://pubmed.ncbi.nlm.nih.gov/30403494
https://pubmed.ncbi.nlm.nih.gov/30403494
Autor:
Roberto J. Botelho, Charlene E. Lancaster, Victoria E. B. Hipolito, Mauricio R. Terebiznik, Cheuk Y. Ho
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 97(1)
Phagocytosis is an evolutionarily conserved process. In Protozoa, phagocytosis fulfills a feeding mechanism, while in Metazoa, phagocytosis diversified to play multiple organismal roles, including immune defence, tissue homeostasis, and remodeling. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae46ce0e21bd0f3f4ca08b58d86a0af9
https://pubmed.ncbi.nlm.nih.gov/29791809
https://pubmed.ncbi.nlm.nih.gov/29791809
Autor:
Roberto J. Botelho, Neha Chauhan, Johannes Ristau, Christian Oertlin, Amra Saric, Shannon McLaughlan, Ivan Topisirovic, Jacqueline A. Diaz, Kristofferson Tandoc, Victoria E. B. Hipolito, Ola Larsson
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 12, p e3000535 (2019)
PLoS Biology, Vol 17, Iss 12, p e3000535 (2019)
The mechanisms that govern organelle adaptation and remodelling remain poorly defined. The endo-lysosomal system degrades cargo from various routes, including endocytosis, phagocytosis, and autophagy. For phagocytes, endosomes and lysosomes (endo-lys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77173a85b4c90fdd6ac592292b5006f8
https://doi.org/10.1101/260257
https://doi.org/10.1101/260257
Publikováno v:
Cellular microbiology. 20(4)
Lysosomes are acidic and hydrolytic organelles responsible for receiving and digesting cargo acquired during endocytosis, phagocytosis, and autophagy. For macrophages and dendritic cells, the lysosome is kingpin, playing a direct role in microbe kill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebde754509b1d14cde2001966431b37
https://pubmed.ncbi.nlm.nih.gov/29349904
https://pubmed.ncbi.nlm.nih.gov/29349904
Autor:
Victoria E. B. Hipolito, Marie T. Killeen, Homa Anvari, Costin N. Antonescu, Stephen Bautista, Alimohammad Asgharian, Suzan El-Rass, Roxana Oriana Florica, Chloe Rapp
Publikováno v:
Developmental biology. 430(1)
The axons of the DA and DB classes of motor neurons fail to reach the dorsal cord in the absence of the guidance cue UNC-6/Netrin or its receptor UNC-5 in C. elegans. However, the axonal processes usually exit their cell bodies in the ventral cord in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15172de6ad4d366a678e913d949e8d7
https://pubmed.ncbi.nlm.nih.gov/28694018
https://pubmed.ncbi.nlm.nih.gov/28694018