Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Victoria C. Cotham"'
Autor:
Deepika Vasudevan, Nicholas K. Clark, Jessica Sam, Victoria C. Cotham, Beatrix Ueberheide, Michael T. Marr, II, Hyung Don Ryoo
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2039-2047 (2017)
Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms. Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) pro
Externí odkaz:
https://doaj.org/article/363f9690a191425680331fa8254dcb71
Autor:
Tobias V Lanz, R Camille Brewer, Peggy P Ho, Kevin M Jude, Daniel Fernandez, Jae-Seung Moon, Ricardo A Fernandes, Alejandro M Gomez, Gabriel-Stefan Nadj, Christopher M Bartley, Ryan D Schubert, Isobel A Hawes, Sara E Vazquez, Manasi Iyer, J Bradley Zuchero, Bianca Teegen, Jeffrey E Dunn, Christopher B Lock, Lucas B Kipp, Victoria C Cotham, Beatrix M Ueberheide, Blake T Aftab, Mark S Anderson, Joseph L DeRisi, Michael R Wilson, Rachael JM Bashford-Rogers, Michael Platten, K Christopher Garcia, Lawrence Steinman, William H Robinson
Publikováno v:
Nature
Nature, vol 603, iss 7900
Nature, vol 603, iss 7900
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the cerebrospinal fluid (CSF) of patients with MS contribute to inflammation and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2318b2d41a42f0170e92995f810de60
https://doi.org/10.1038/s41586-022-04432-7
https://doi.org/10.1038/s41586-022-04432-7
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 228:115337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8993e97cebf95b79633ff2534385b8f
https://doi.org/10.1016/j.jpba.2023.115337
https://doi.org/10.1016/j.jpba.2023.115337
Autor:
Edwin E. Escobar, Jamie P. Butalewicz, Haoyi Wu, Seema Irani, Joshua E. Mayfield, Meena Tadros, Jennifer S. Brodbelt, Yan Jessie Zhang, Mukesh Kumar Venkat Ramani, Victoria C. Cotham, Rosamaria Y. Moreno
Publikováno v:
ACS Chem Biol
The phosphorylation states of RNA polymerase II coordinate the process of eukaryotic transcription by recruitment of transcription regulators. The individual residues of the repetitive heptad of the C-terminal domain (CTD) of the biggest subunit of R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee83e328dbc5ab82b20770d0506fc49
https://europepmc.org/articles/PMC8018230/
https://europepmc.org/articles/PMC8018230/
Autor:
Victoria C. Cotham, Michelle Byrom, Raghav Shroff, Andrew D. Ellington, Jennifer S. Brodbelt, Dustin R. Klein, Simon d'Oelsnitz, Ross Thyer
Publikováno v:
Nature biotechnology
Incorporation of the rare amino acid selenocysteine to form diselenide bonds can improve stability and function of synthetic peptide therapeutics. However, application of this approach to recombinant proteins has been hampered by heterogeneous incorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a6eb2659c354a5d2992849ed699eb5
http://europepmc.org/articles/PMC6035053
http://europepmc.org/articles/PMC6035053
Publikováno v:
Analytical Chemistry. 89:6498-6504
Mass spectrometry (MS) has emerged as a powerful tool within the growing field of immunoproteomics, which aims to understand antibody-mediated immunity at the molecular-level based on the direct determination of serological antibody repertoire. To da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c7352f789707dc6bca612abf6be02b
https://doi.org/10.1021/acs.analchem.7b00564
https://doi.org/10.1021/acs.analchem.7b00564
Autor:
Jennifer S. Brodbelt, Joe R. Cannon, Anjana Ram, Yan Jessie Zhang, David S. Gilmour, Seema Irani, Victoria C. Cotham, Wendy L. Matthews, Joshua E. Mayfield, Michelle R. Robinson
Publikováno v:
ACS Chemical Biology. 12:153-162
Phosphorylation of the C-terminal domain of RNA polymerase II (CTD) plays an essential role in eukaryotic transcription by recruiting transcriptional regulatory factors to the active polymerase. However, the scarcity of basic residues and repetitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f80a773ee02f3768057a5b85a8fb2d4
https://doi.org/10.1021/acschembio.6b00729
https://doi.org/10.1021/acschembio.6b00729
Publikováno v:
Analytical Chemistry. 88:4004-4013
Monoclonal antibodies (mAbs) are a rapidly advancing class of therapeutic glycoproteins that possess wide clinical utility owing to their biocompatibility, high antigen specificity, and targeted immune stimulation. These therapeutic properties depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5391f08dbc4a7eec9c6e7b65836aa24
https://doi.org/10.1021/acs.analchem.6b00302
https://doi.org/10.1021/acs.analchem.6b00302
Autor:
Nicholas K. Clark, Michael T. Marr, Deepika Vasudevan, Jessica Sam, Beatrix Ueberheide, Victoria C. Cotham, Hyung Don Ryoo
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2039-2047 (2017)
Summary Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms. Here, we use a Drosophila model to demonstrate that antimicrobial peptide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836ac4aa8165a4981aaa5c1fd3b71d0c
https://pubmed.ncbi.nlm.nih.gov/29166596
https://pubmed.ncbi.nlm.nih.gov/29166596
The labile nature of phosphoryl groups has presented a long-standing challenge for the characterization of protein phosphorylation via conventional mass spectrometry-based bottom-up proteomics methods. Collision-induced dissociation (CID) causes pref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e28bc5f6f0a3d174c4c32d14235af9e
https://europepmc.org/articles/PMC5477467/
https://europepmc.org/articles/PMC5477467/