Výsledky vyhledávání - "Victoria Alers"

Data from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis

Autor: Karthikeyan Mythreye, Nam Y. Lee, Eugenia V. Broude, Balázs Győrffy, Nadine Hempel, Tapasya Srivastava, Prabhjot Kaur, Shrikant Pradhan, Victoria Alers, Ben Horst, Laura M. Jenkins, Priyanka Singh

Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0964e26d2798fd26b9ba222f278b1c36
https://doi.org/10.1158/0008-5472.c.6509868.v1

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Figure S4 from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis

Growth curves of (i) HMEC-1 and MEEC cells in the presence or absence of 100pM recombinant Inhibin A over 7 days or (ii) HMEC-1 migration through fibronectin coated transwells for 6 hrs towards control serum free media or media containing 300 pM reco

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https://doi.org/10.1158/0008-5472.22417524

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Figure S7 from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis

(i) qRT-PCR analysis for mRNA expression of type I receptors ALK1-7 in endothelial (HMEC-1) and epithelial (SKOV3) cells. (ii) Tube formation of HMEC-1 cells in the presence of Inhibin A alone or with 5mM Dorsomorphin (DM) and SB431542 (SB). Number o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b8a12d292609589d82d667211229ef
https://doi.org/10.1158/0008-5472.22417518.v1

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Figure S1 from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis

(i) Sample images of immunohistochemistry (IHC) using IgG or anti-Inhibina antibody on the same ovarian tumor. (ii) Zoomed in images of regions IHC Fig 1A (Human Ovary Cancer Tissue Microarray, Protein Biotechnologies) of either normal tissue or diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c94ca11aabe18ec121345c73e9f6b5
https://doi.org/10.1158/0008-5472.22417533.v1

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Figure S3 from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis

Tube formation of HMEC-1 cells (i)using two independent sources of recombinant Inhibin A: A I (Sigma Aldrich) and A II (R & D Systems) or (ii) in the presence and absence of recombinant 300 pM Inhibin A alone or with anti-Inhibinα antibody (10 µg/m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685af7e36e005fc90aeac012f10e4901
https://doi.org/10.1158/0008-5472.22417527.v1

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Figure S8 from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis

Representative western blot of lysates from 6 hr serum starved HMEC-1 cells incubated with 10ng/ml Activin up to 40 min, followed by immunoblotting of lysates as indicated. Quantitation from two independent biological trials is presented (right graph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ec2c3f9311092b645d2fe40b4decef
https://doi.org/10.1158/0008-5472.22417515.v1

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Figure S5_S6 from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis

Figure S5: Representative western blot of 6 hr serum starved HMEC-1 cells treated with CM from either shControl or shINHA SKOV3 cells. Anti-INHA (polyclonal; 10 µg/ml; #sc22048, Santa Cruz) antibody was used as indicated. Samples were immunoblotted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982575f924cf04bc66f9ba84066f2f91
https://doi.org/10.1158/0008-5472.22417521.v1

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Figure S2 from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis

(i) (Left) qRT PCR analysis of of INHA mRNA with a second shRNA (shINHA2) to INHA (shINHA2) in endothelial cells compared to shControl2 (Methods) followed by (Middle) tube formation of HMEC-1 cells. (Right) Number of meshes represents an average of 3

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https://doi.org/10.1158/0008-5472.22417530

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FASN inhibition as a potential treatment for endocrine-resistant breast cancer

Autor: Bryan Mcclellan, Linda A. deGraffenried, Aleksandra Gruslova, Gangadhara R. Sareddy, Victoria Alers, Andrew Brenner, Ratna K. Vadlamudi, Michael E. Garcia, Suryavathi Viswanadhapalli, Tim Huang, Henriette U. Balinda

Publikováno v: Breast Cancer Research and Treatment. 187:375-386

The majority of breast cancers are estrogen receptor (ERα) positive making endocrine therapy a mainstay for these patients. Unfortunately, resistance to endocrine therapy is a common occurrence. Fatty acid synthase (FASN) is a key enzyme in lipid bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69697bbbdc0fb50e263b1212a2e5d318
https://doi.org/10.1007/s10549-021-06231-6

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