Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Victoria A. Appleman"'
PDF file - 618K, MEK/ERK and PI3K/AKT signaling is required for KRASG12D- and BRAFV600E-induced survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f39afe31f7bd94e040ca638445d97a5
https://doi.org/10.1158/1541-7786.22517479
https://doi.org/10.1158/1541-7786.22517479
PDF file - 415K, Combined inhibition of MEK and IGF1R reduces pancreatic cancer cell survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253bf27a2e08523a6ea936f29fcc90bc
https://doi.org/10.1158/1541-7786.22517470.v1
https://doi.org/10.1158/1541-7786.22517470.v1
PDF file - 186K, Tumors formed by PDECs with IGF1R knockdown display normal IGF1R protein levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9368ab98f1ff86ba8b72aec4a5b918fd
https://doi.org/10.1158/1541-7786.22517473
https://doi.org/10.1158/1541-7786.22517473
PDF file - 270K, IGF and EGF family ligand expression in KRASG12D- and BRAFV600E-expressing PDECs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c48be57a6cdfe5bb7afbeebed22c344
https://doi.org/10.1158/1541-7786.22517476.v1
https://doi.org/10.1158/1541-7786.22517476.v1
PDF file - 73K, Methods and reagents excluded from text due to space constraints
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b55f83071f52cefef84cca5b06cc8fe
https://doi.org/10.1158/1541-7786.22517464
https://doi.org/10.1158/1541-7786.22517464
PDF file - 7.8MB, KRASG12D and BRAFV600E induce pancreatic tumors in an orthotopic model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f36571283e0d16b18bbcdc23c2cd506
https://doi.org/10.1158/1541-7786.22517482.v1
https://doi.org/10.1158/1541-7786.22517482.v1
Autor:
Brian C. Lewis, Makoto Sano, Masahiko Sugitani, Tadatoshi Takayama, Shintaro Yamazaki, Norimichi Nemoto, Lihua Julie Zhu, Victoria A. Appleman, David S. Klimstra, Brian Quattrochi, Jianhong Ou, Wilfredo E. DeJesus-Monge, Nao Yoshida, David R. Driscoll
Publikováno v:
Neoplasia (New York, N.Y.)
Pancreatic ductal adenocarcinoma (PDAC), a poor prognostic cancer, commonly develops following activating mutations in the KRAS oncogene. Activation of WNT signaling is also commonly observed in PDAC. To ascertain the impact of postnatal activation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1539afdaa64ddb4f2c7d2b3f24f9dfbe
https://doi.org/10.1016/j.neo.2016.11.004
https://doi.org/10.1016/j.neo.2016.11.004
Autor:
Tiquella Hatten, Maria Borland, Victoria A. Appleman, Michael D. Smith, Adnan O. Abu-Yousif, Michelle L. Ganno
Publikováno v:
Cancer Research. 80:974-974
TAK-164 is an antibody drug conjugate comprised of a full length, fully human IgG1 monoclonal antibody (mAb) directed towards the human extra-cellular domain of guanylyl cyclase C (GCC). The mAb is conjugated using ImmunoGen's peptide-linked indolino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57f0372ef5f3f75fe729ec8fcf6ded94
https://doi.org/10.1158/1538-7445.am2020-974
https://doi.org/10.1158/1538-7445.am2020-974
Autor:
Melissa West, Victoria A. Appleman, Valeria Fantin, Michele McTigue, Sergei Timofeevski, Matthew D. Falk, Alexei Brooun, Scott Rp McDonnell, Tod Smeal, Al Charest, Wenyue Hu, Wei Liu, Ya-Li Deng, Katy A. Wong, Timothy C. Nichols, Justine L. Lam, Ping Jiang, Helen Y. Zou, Qiuhua Li, Lars D. Engstrom, Timothy Affolter, Ted William Johnson, Patrick B. Lappin
Publikováno v:
Proceedings of the National Academy of Sciences. 112:3493-3498
Oncogenic c-ros oncogene1 (ROS1) fusion kinases have been identified in a variety of human cancers and are attractive targets for cancer therapy. The MET/ALK/ROS1 inhibitor crizotinib (Xalkori, PF-02341066) has demonstrated promising clinical activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5769ead600f455be1dcabb5bf6780f26
https://doi.org/10.1073/pnas.1420785112
https://doi.org/10.1073/pnas.1420785112