Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Victoria, Kutilek"'
Autor:
Prasanthi Geda, Mark A. McCoy, Liping Yang, Chaomin Li, Armetta D. Hill, Xavier Fradera, Marianne L. Spatz, Matthew Ernst Voss, Carolyn Michele Cammarano, Pierre Daublain, Xiao Wang, Christopher F. Thompson, B. Wesley Trotter, C. Gary Marshall, Michael H. Reutershan, Peter Goldenblatt, Latha G. Nair, Manami Shizuka, Tammie C. Yeh, John G. Cryan, Isabelle Dussault, Michelle Martinez, Mingmei Cai, Raymond A. Kemper, Binyuan Sun, Michelle R. Machacek, Dietrich Steinhuebel, Giovanna Scapin, Michael D. Altman, Stephane L. Bogen, Matthew Christopher, Dapeng Chen, Victoria Kutilek, Weidong Pan
Publikováno v:
Journal of Medicinal Chemistry. 64:16213-16241
Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant efforts toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f003ba884dc7f950fc132b2a33cadf
https://doi.org/10.1021/acs.jmedchem.1c01524
https://doi.org/10.1021/acs.jmedchem.1c01524
Autor:
Michael H, Reutershan, Michelle R, Machacek, Michael D, Altman, Stephane, Bogen, Mingmei, Cai, Carolyn, Cammarano, Dapeng, Chen, Matthew, Christopher, John, Cryan, Pierre, Daublain, Xavier, Fradera, Prasanthi, Geda, Peter, Goldenblatt, Armetta D, Hill, Raymond A, Kemper, Victoria, Kutilek, Chaomin, Li, Michelle, Martinez, Mark, McCoy, Latha, Nair, Weidong, Pan, Christopher F, Thompson, Giovanna, Scapin, Manami, Shizuka, Marianne L, Spatz, Dietrich, Steinhuebel, Binyuan, Sun, Matthew E, Voss, Xiao, Wang, Liping, Yang, Tammie C, Yeh, Isabelle, Dussault, C Gary, Marshall, B Wesley, Trotter
Publikováno v:
Journal of medicinal chemistry. 64(21)
Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant efforts toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c70be0458a74b9595c42b9269bd0b63
https://pubmed.ncbi.nlm.nih.gov/34714078
https://pubmed.ncbi.nlm.nih.gov/34714078
Autor:
Victoria Kutilek, Zhao Wang, Rafael Fernandez, James R. Tata, Li Zheng, Xuan Mo, Brian D. Dill, Meir Glick, Nirodhini Siriwardana, Jonathan D. Mortison, Ivan Cornella-Taracido, Brian M. Andresen, Julie Di Bernardo, Yuting Xu, Andy Liaw, Matthew Christopher, Oleg Ursu, Benjamin Ruprecht, Huijun Wang, An Chi
Publikováno v:
Nature chemical biology. 16(10)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fae67c605f7ac45e6ea429f134b9a6
https://pubmed.ncbi.nlm.nih.gov/32690943
https://pubmed.ncbi.nlm.nih.gov/32690943
Autor:
James R. Tata, Oleg Ursu, Nirodhini Siriwardana, Brian M. Andresen, Li Zheng, Brian D. Dill, Benjamin Ruprecht, Huijun Wang, Matthew Christopher, Julie Di Bernardo, Ivan Cornella-Taracido, Zhao Wang, Victoria Kutilek, Jonathan D. Mortison, Andy Liaw, Meir Glick, An Chi, Yuting Xu, Rafael Fernandez, Xuan Mo
Publikováno v:
Nature chemical biology. 16(10)
Mass spectrometry-based discovery proteomics is an essential tool for the proximal readout of cellular drug action. Here, we apply a robust proteomic workflow to rapidly profile the proteomes of five lung cancer cell lines in response to more than 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc31110e1cbef5e10dc4f365729590e
https://pubmed.ncbi.nlm.nih.gov/32792589
https://pubmed.ncbi.nlm.nih.gov/32792589
Autor:
Nathaniel L. Elsen, Zangwei Xu, Peter J. Dandliker, Peter Saradjian, Keith W. Rickert, Berengere Sauvagnat, Nadya Smotrov, Dawn L. Hall, Elliott B. Nickbarg, Yiping Chen, Sujata Sharma, Kevin J. Lumb, Maria Kornienko, Noel Byrne, Chad Chamberlin, Christine Andrews, Samantha J Allen, Ilona Kariv, Jennifer M. Shipman, Patrick J. Curran, Kevin G. Coleman, Beutel Bruce A, Rachael E. Ford, Victoria Kutilek, Andrew Hashke, Rafael Fernandez, Tianxiao Sun, Matthew Richards, Ryan Boinay
Publikováno v:
SLAS Discovery. 21:608-619
The primary objective of early drug discovery is to associate druggable target space with a desired phenotype. The inability to efficiently associate these often leads to failure early in the drug discovery process. In this proof-of-concept study, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321009edd98ca17a57d26928e293e5e3
https://doi.org/10.1177/1087057116637353
https://doi.org/10.1177/1087057116637353
Autor:
Graham Smith, Elliott B. Nickbarg, Chad Chamberlin, Noreen F. Rizvi, Christine Andrews, Victoria Kutilek, Peter Saradjian, Brooke M Swalm, Jennifer O'Neil, Patrick J. Curran, Peter J. Dandliker, Sam Kattar, Deborah A Flusberg
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(2)
The Myc oncogene is overexpressed in many cancers, yet targeting it for cancer therapy has remained elusive. One strategy for inhibition of Myc expression is through stabilization of the G-quadruplex (G4), a G-rich DNA secondary structure found withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc21d5d0d08922e9d47ce0a1ade59dc
https://pubmed.ncbi.nlm.nih.gov/30204533
https://pubmed.ncbi.nlm.nih.gov/30204533
Autor:
Kristen Wiley, Jennifer Piesvaux, Gopal Parthasarathy, Mario van der Stelt, Seppe Leysen, Arthur Oubrie, Geert C. van Almen, J. Richard Miller, Nathaniel L. Elsen, Luc Brunsveld, Hongjun Zhang, Maria Kornienko, Stephen M. Soisson, Sunil Nagpal, Victoria Kutilek, Kenneth Jay Barr, Craig C. Correll, Marcel Scheepstra, Christian Ottmann, B. Wesley Trotter, Sujata Sharma, Hans van Eenennaam
Publikováno v:
Nature Communications, 6:9833, 1-10. Nature Publishing Group
NATURE COMMUNICATIONS, 6, 8833
Nature Communications
NATURE COMMUNICATIONS, 6, 8833
Nature Communications
RORγt is critical for the differentiation and proliferation of Th17 cells associated with several chronic autoimmune diseases. We report the discovery of a novel allosteric binding site on the nuclear receptor RORγt. Co-crystallization of the ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55efce9b90797151f58ad3c27895a573
https://hdl.handle.net/1887/62166
https://hdl.handle.net/1887/62166
Publikováno v:
Food and Agricultural Immunology. 13:103-114
The protein profile of Tilletia indica, the causal agent of Karnal bunt, was analyzed by SDS-PAGE and compared to protein profiles of T. barclayana, T. tritici, T. controversa and T. laevis. Based on these results, antibodies were developed against a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62bd72eb48a8dc7622044bcebbdcd2d9
https://doi.org/10.1080/09540100120055675
https://doi.org/10.1080/09540100120055675