Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Victoria, Auerbuch"'
Autor:
David Balderas, Mané Ohanyan, Pablo A Alvarez, Erin Mettert, Natasha Tanner, Patricia J Kiley, Victoria Auerbuch
Publikováno v:
PLoS Genetics, Vol 18, Iss 7, p e1010321 (2022)
The type III secretion system (T3SS) is an appendage used by many bacterial pathogens, such as pathogenic Yersinia, to subvert host defenses. However, because the T3SS is energetically costly and immunogenic, it must be tightly regulated in response
Externí odkaz:
https://doaj.org/article/31175d260d99424d9eccf832051d18ce
Autor:
David Balderas, Erin Mettert, Hanh N. Lam, Rajdeep Banerjee, Tomas Gverzdys, Pablo Alvarez, Geetha Saarunya, Natasha Tanner, Adam Zoubedi, Yahan Wei, Patricia J. Kiley, Victoria Auerbuch
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
How bacteria adapt to the changing environment within the host is critical for their ability to survive and cause disease. For example, the mammalian host severely restricts iron availability to limit bacterial growth, referred to as nutritional immu
Externí odkaz:
https://doaj.org/article/44ff9237115c41d5a3c3c307d1bab8d9
Autor:
Diana Hooker-Romero, Erin Mettert, Leah Schwiesow, David Balderas, Pablo A Alvarez, Anadin Kicin, Azuah L Gonzalez, Gregory V Plano, Patricia J Kiley, Victoria Auerbuch
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008001 (2019)
The enteropathogen Yersinia pseudotuberculosis and the related plague agent Y. pestis require the Ysc type III secretion system (T3SS) to subvert phagocyte defense mechanisms and cause disease. Yet type III secretion (T3S) in Yersinia induces growth
Externí odkaz:
https://doaj.org/article/2c5d6fed357a4d40ba63500af239e52f
Autor:
Matthew S. Francis, Victoria Auerbuch
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Externí odkaz:
https://doaj.org/article/9cdbb70b0c914768b0874b0203b67308
Autor:
Jessica M. Morgan, Hanh N. Lam, Jocelyn Delgado, Justin Luu, Sina Mohammadi, Ralph R. Isberg, Helen Wang, Victoria Auerbuch
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism. While the T3SS represents an attractive drug target and dozens of compounds
Externí odkaz:
https://doaj.org/article/08fefb0f1a9647a39c611fc2f3c28596
Autor:
Leah Schwiesow, Erin Mettert, Yahan Wei, Halie K. Miller, Natalia G. Herrera, David Balderas, Patricia J. Kiley, Victoria Auerbuch
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Despite the mammalian host actively sequestering iron to limit pathogenicity, heme (or hemin when oxidized) and hemoproteins serve as important sources of iron for many bloodborne pathogens. The HmuRSTUV hemin uptake system allows Yersinia species to
Externí odkaz:
https://doaj.org/article/af487e1748854e81884d87212607dd04
Autor:
Jessica M. Morgan, Miles C. Duncan, Kevin S. Johnson, Andreas Diepold, Hanh Lam, Allison J. Dupzyk, Lexi R. Martin, Weng Ruh Wong, Judith P. Armitage, Roger G. Linington, Victoria Auerbuch
Publikováno v:
mSphere, Vol 2, Iss 1 (2017)
ABSTRACT The type III secretion system (T3SS) is a bacterial virulence factor expressed by dozens of Gram-negative pathogens but largely absent from commensals. The T3SS is an attractive target for antimicrobial agents that may disarm pathogenic bact
Externí odkaz:
https://doaj.org/article/74f6ceb0df4a419da1d4d7f0ac24f76e
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171406 (2017)
Infection of human cells with Yersinia pseudotuberculosis expressing a functional type III secretion system (T3SS) leads to activation of host NF-κB. We show that the Yersinia T3SS activates distinct NF-κB pathways dependent upon bacterial subcellu
Externí odkaz:
https://doaj.org/article/989e23cf033a4f0dae2187fc3de56355
Publikováno v:
Annual Review of Microbiology. 74:221-245
Microbial pathogens have evolved complex mechanisms to interface with host cells in order to evade host defenses and replicate. However, mammalian innate immune receptors detect the presence of molecules unique to the microbial world or sense the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa26846e574057e7fcac7754df80345c
https://doi.org/10.1146/annurev-micro-020518-120221
https://doi.org/10.1146/annurev-micro-020518-120221
Autor:
Natasha Tanner, David Balderas, Patricia J. Kiley, Pablo Alvarez, Mané Ohanyan, Victoria Auerbuch, Erin L. Mettert
The type III secretion system (T3SS) is a appendage used by many bacterial pathogens, such as pathogenic Yersinia, to subvert host defenses. However, because the T3SS is energetically costly and immunogenic, it must be tightly regulated in response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0138b2082b0d55a3e812f1fb3cde24e
https://doi.org/10.1101/2021.10.26.466021
https://doi.org/10.1101/2021.10.26.466021
