Výsledky vyhledávání - "Victor Z. de Antonio"

Pulmonary delivery of flecainide causes a rate‐dependent predominant effect on atrial compared with ventricular depolarization duration revealed by intracardiac recordings in an intact porcine model

Autor: Alexandre A. Marum, Anderson C. Silva, Victor Z. de Antonio, Alexandre L. Bortolotto, Richard L. Verrier, Bruna Araujo Silva, Luiz Belardinelli, Fernando G. Stocco

Publikováno v: Journal of Cardiovascular Electrophysiology. 29:1563-1569

BACKGROUND Pulmonary delivery of flecainide results in the rapid conversion of atrial fibrillation (AF) to normal sinus rhythm in large-animal models and is safe and well-tolerated by normal human volunteers. OBJECTIVE We investigated the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe1e48151db17938b5c98ac5e7b2257
https://doi.org/10.1111/jce.13708

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Comparative Pharmacokinetic and Electrocardiographic Effects of Intratracheal and Intravenous Administration of Flecainide in Anesthetized Pigs

Autor: Ederson Evaristo, Richard L. Verrier, Anderson C. Silva, Victor Z. de Antonio, Narasimhan Rangachari, Luiz Belardinelli, Juergen Pfeiffer, Fernando G. Stocco

Publikováno v: Journal of Cardiovascular Pharmacology. 72:129-135

We compared the pharmacokinetic (PK) profile and electrocardiographic (ECG) changes in response to intratracheal instillation of flecainide acetate into the left atrium and ventricle with intravenous (IV) flecainide acetate administration. In 12 clos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5f3dfd7a1df85aa08ebc946e0ca045
https://doi.org/10.1097/fjc.0000000000000605

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Optimizing flecainide plasma concentration profile for atrial fibrillation conversion while minimizing adverse ventricular effects by rapid, low-dose intratracheal or intravenous administration

Autor: Luiz Belardinelli, Alexandre L. Bortolotto, Bruna Araujo Silva, Richard L. Verrier, Alexandre A. Marum, Anderson C. Silva, Victor Z. de Antonio

Publikováno v: International journal of cardiology. 274

Background We investigated whether rapid administration of a low dose of flecainide, either intratracheally or intravenously (IV), could accelerate conversion of atrial fibrillation (AF) while reducing adverse ventricular effects. Methods Flecainide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aebf886d4b7e955b7bb8981ed8e9544
https://pubmed.ncbi.nlm.nih.gov/30217428

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Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model

Autor: Richard L. Verrier, Bruna Araujo Silva, Alexandre A. Marum, Ederson Evaristo, Anderson C. Silva, Victor Z. de Antonio, Alexandre L. Bortolotto, Fernando G. Stocco, Luiz Belardinelli

Publikováno v: Heart rhythm. 15(12)

Background Pulmonary delivery of antiarrhythmic agents has the potential to increase rapidly targeted drug concentrations in pulmonary veins and left atrium to terminate atrial fibrillation (AF). Objective We evaluated the efficacy of flecainide admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae36a6b9bfa79778c91aa17213beed88
https://pubmed.ncbi.nlm.nih.gov/29958990

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EXERCISE AND PHARMACOLOGIC STRESS-INDUCED T-WAVE HETEROGENEITY FOR DETECTION OF CLINICALLY SIGNIFICANT CORONARY ARTERY STENOSIS

Autor: Kalon K.L. Ho, Jakub Sroubek, Anderson C. Silva, Bruce D. Nearing, Ernest V. Gervino, Fernando G. Stocco, Richard L. Verrier, Victor Z. de Antonio

Publikováno v: Journal of the American College of Cardiology. 71:A155

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72e6fe45905714abc03bda466070e241
https://doi.org/10.1016/s0735-1097(18)30696-x

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PULMONARY DELIVERY OF THE CLASS IC ANTIARRHYTHMIC AGENT FLECAINIDE EXERTS A PREDOMINANT EFFECT ON ATRIAL COMPARED TO VENTRICULAR DEPOLARIZATION DURATION REVEALED BY INTRACARDIAC RECORDINGS

Autor: Richard L. Verrier, Fernando G. Stocco, Narsi Rangachari, Anderson C. Silva, Victor Z. de Antonio, Luiz Belardinelli

Publikováno v: Journal of the American College of Cardiology. 71:A395

Pulmonary delivery of antiarrhythmic agents has the potential to target atrial tissue and pulmonary veins to terminate atrial fibrillation (AF) rapidly, as shown in preclinical studies. Investigations in healthy human volunteers reported that inhaled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1251b9a1f59836ca2ded54e16e08f97
https://doi.org/10.1016/s0735-1097(18)30936-7

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