Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Victor W. Rodwell"'
Autor:
Sucharita Bose, C. Nicklaus Steussy, Daneli López-Pérez, Tim Schmidt, Samadhi C. Kulathunga, Mohamed N. Seleem, Mark Lipton, Andrew D. Mesecar, Victor W. Rodwell, Cynthia V. Stauffacher
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
High-throughput in vitro screening and crystal structures identify a non-statin inhibitor of HMG-CoA reductase for novel antibacterial drug design.
Externí odkaz:
https://doaj.org/article/ff33f7666d8d44099aa084b1ad4f545f
Autor:
Richard L. Imblum, Victor W. Rodwell
Publikováno v:
Journal of Lipid Research, Vol 15, Iss 3, Pp 211-222 (1974)
Two enzymes of polyisoprenoid synthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (mevalonate:NADP oxidoreductase [acylating CoA] , EC 1.1.1.34) and mevalonate kinase (ATP:mevalonate 5-phosphotransferase, EC 2.7.1.36), are present in
Externí odkaz:
https://doaj.org/article/de758bdd2a804c679941a525ffd7ec04
Gain a full understanding of the principles of biochemistry as it relates to clinical medicine A Doody's Core Title for 2020! The Thirty-First Edition of Harper's Illustrated Biochemistry continues to emphasize the link between biochemistry and the u
Gain a thorough understanding of the principles ofbiochemistry as they relate to the study of clinical medicine A Doody's Core Title for 2017! THE BEST REVIEW FOR THE USMLE! The Thirtieth Edition of Harper's Illustrated Biochemistry combines outstand
Autor:
Calvin Steussy, Victor W. Rodwell, Autumn Sutherlin, Alison M Tetrick, Cynthia V. Stauffacher, Aaron D Robison, Jeffrey T Knight
Publikováno v:
Biochemistry. 45:14407-14414
Recent structural studies of the HMG-CoA synthase members of the thiolase superfamily have shown that the catalytic loop containing the nucleophilic cysteine follows the phi and psi angle pattern of a II' beta turn. However, the i + 1 residue is cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7084fb1445862b6a93f043dde3bd50
https://doi.org/10.1021/bi061505q
https://doi.org/10.1021/bi061505q
Autor:
John W. Burgner, Cynthia V. Stauffacher, Anthony A. Vartia, C. Nicklaus Steussy, Autumn Sutherlin, Victor W. Rodwell
Publikováno v:
Biochemistry. 44:14256-14267
Biosynthesis of the isoprenoid precursor, isopentenyl diphosphate, is a critical function in all independently living organisms. There are two major pathways for this synthesis, the non-mevalonate pathway found in most eubacteria and the mevalonate p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f650f7c38710be31416dd2cf2c4c41d
https://doi.org/10.1021/bi051487x
https://doi.org/10.1021/bi051487x
Publikováno v:
Protein Science. 14:1134-1139
The six enzymes of the mevalonate pathway of isopentenyl diphosphate biosynthesis represent potential for addressing a pressing human health concern, the development of antibiotics against resistant strains of the Gram-positive streptococci. We previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2ec475b48ccd4e1b2a816078ab5d44
https://doi.org/10.1110/ps.041210405
https://doi.org/10.1110/ps.041210405
Autor:
Matija Hedl, Victor W. Rodwell
Publikováno v:
Protein Science. 13:1693-1697
There are two structural classes of HMG-CoA reductase, the third enzyme of the mevalonate pathway of isopentenyl diphosphate biosynthesis-the Class I enzymes of eukaryotes and the Class II enzymes of certain eubacteria. Structural requirements for li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ade11d7782377eebdef5620d313f73e
https://doi.org/10.1110/ps.03597504
https://doi.org/10.1110/ps.03597504
Autor:
Victor W. Rodwell, Matija Hedl
Publikováno v:
Protein Science. 13:687-693
Gram-positive pathogens synthesize isopentenyl diphosphate, the five-carbon precursor of isoprenoids, via the mevalonate pathway. The enzymes of this pathway are essential for the survival of these organisms, and thus may represent possible targets f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5734e98f7bd459b4563c36b8b512be20
https://doi.org/10.1110/ps.03367504
https://doi.org/10.1110/ps.03367504
Publikováno v:
Journal of Biological Chemistry. 278:19933-19938
Hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the primary target in the current clinical treatment of hypercholesterolemias with specific inhibitors of the "statin" family. Statins are excellent inhibitors of the class I (human) enzyme but relativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5658e77c8b94625828305dd21d7886ca
https://doi.org/10.1074/jbc.m213006200
https://doi.org/10.1074/jbc.m213006200