Zobrazeno 1 - 10
of 775
pro vyhledávání: '"Victor W. Pike"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The 2,2,2-trifluoroethoxy group increasingly features in drugs and potential tracers for biomedical imaging with positron emission tomography (PET). Herein, we describe a rapid and transition metal-free conversion of fluoroform with paraform
Externí odkaz:
https://doaj.org/article/30644c5756d942b890538d65ccd30767
Autor:
Sridhar Goud Nerella, Sanjay Telu, Jeih-San Liow, Madeline D. Jenkins, Sami S. Zoghbi, Juan L. Gomez, Michael Michaelides, Mark A. G. Eldridge, Barry J. Richmond, Robert B. Innis, Victor W. Pike
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Chemogenetic tools are designed to control neuronal signaling. These tools have the potential to contribute to the understanding of neuropsychiatric disorders and to the development of new treatments. One such chemogenetic technology compris
Externí odkaz:
https://doaj.org/article/dc85f38a8fc449c2a2f81a76b0068687
Autor:
Lisheng Cai, Jeih-San Liow, Cheryl L. Morse, Sanjay Telu, Riley Davies, Lester S. Manly, Sami S. Zoghbi, Frederick T. Chin, Robert B. Innis, Victor W. Pike
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-11 (2023)
Key points Question: Do GluN2B radioligands 11C-NR2B-Me enantiomers show cross-binding with σ1 receptors in brain in vivo? Pertinent findings: 11C-(+)-NR2B-Me, 11C-(−)-NR2B-Me, 11C-(S)-NR2B-SMe, and 11C-(R)-NR2B-SMe give specific signals in whole
Externí odkaz:
https://doaj.org/article/0a8dea1580224d03a86adc98e17465ab
Autor:
Jae-Hoon Lee, Mattia Veronese, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Mohammad B. Haskali, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis, Paolo Zanotti-Fregonara
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Background Previous studies found that the positron emission tomography (PET) radioligand [18F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to assess kinetic model
Externí odkaz:
https://doaj.org/article/52d77ecbd92a4d8aaad302f00ded1beb
Publikováno v:
ACS Omega, Vol 5, Iss 31, Pp 19557-19564 (2020)
Externí odkaz:
https://doaj.org/article/f4afd5a7114d4112b38760a7f089ef57
Autor:
Stal Shrestha, Min-Jeong Kim, Mark Eldridge, Michael L. Lehmann, Michael Frankland, Jeih-San Liow, Zu-Xi Yu, Michelle Cortes-Salva, Sanjay Telu, Ioline D. Henter, Evan Gallagher, Jae-Hoon Lee, J. Megan Fredericks, Chelsie Poffenberger, George Tye, Yanira Ruiz-Perdomo, Fernanda Juarez Anaya, Jose A. Montero Santamaria, Robert L. Gladding, Sami S. Zoghbi, Masahiro Fujita, James D. Katz, Victor W. Pike, Robert B. Innis
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radiolig
Externí odkaz:
https://doaj.org/article/549fdcb2b5f34261b797487884d7bade
Autor:
Jae-Hoon Lee, Jeih-San Liow, Soumen Paul, Cheryl L. Morse, Mohammad B. Haskali, Lester Manly, Sergey Shcherbinin, J. Craig Ruble, Nancy Kant, Emily C. Collins, Hugh N. Nuthall, Paolo Zanotti-Fregonara, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Background Previous studies found that [18F]LSN3316612 was a promising positron emission tomography (PET) radioligand for imaging O-GlcNAcase in nonhuman primates and human volunteers. This study sought to further evaluate the suitability of
Externí odkaz:
https://doaj.org/article/bb5eb72643d84f0aadd17788a06265b4
Autor:
Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Background Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist li
Externí odkaz:
https://doaj.org/article/10bc2306d18e432dbaa5a6c3fa933174
Autor:
Carlotta Taddei, Victor W. Pike
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-31 (2019)
Abstract [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and
Externí odkaz:
https://doaj.org/article/c3cbbcb991084cfe9eb6b1ccd1498805
Autor:
Min-Jeong Kim, Meghan McGwier, Kimberly J. Jenko, Joseph Snow, Cheryl Morse, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis, William C. Kreisl
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 7, Pp 1327-1331 (2019)
Abstract This study used 11C‐PBR28 positron emission tomography (PET) imaging to determine whether levels of 18‐kDa translocator protein (TSPO), an inflammation‐specific biomarker, are increased in frontotemporal lobar degeneration (FTLD) patie
Externí odkaz:
https://doaj.org/article/4eb0047842b247e58d7ae1375df09343