Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Victor V Pineda"'
Autor:
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith, Daniel Meza, Masanao Yajima, Richard P Beyer, Kathleen F Kerr, Daniel J Davis, Catherine H Gillespie, Jessica M Snyder, Piper M Treuting, Matt Kaeberlein
Publikováno v:
eLife, Vol 5 (2016)
The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy
Externí odkaz:
https://doaj.org/article/789d01e84d514ea888c6cbb9326c49be
Autor:
Randell T Libby, Katharine A Hagerman, Victor V Pineda, Rachel Lau, Diane H Cho, Sandy L Baccam, Michelle M Axford, John D Cleary, James M Moore, Bryce L Sopher, Stephen J Tapscott, Galina N Filippova, Christopher E Pearson, Albert R La Spada
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000257 (2008)
At least 25 inherited disorders in humans result from microsatellite repeat expansion. Dramatic variation in repeat instability occurs at different disease loci and between different tissues; however, cis-elements and trans-factors regulating the ins
Externí odkaz:
https://doaj.org/article/55d88fccdd2d45c6b6029d210e06b1de
Publikováno v:
Translational Medicine of Aging, Vol 3, Iss, Pp 90-97 (2019)
Dietary restriction (DR) extends lifespan in a wide range of model organisms, including Caenorhabditis elegans. It is an interesting but yet to be addressed question whether hormones serve as a systemic mechanism that mediates this longevity response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d208719fa1cd460636f0a48946bad9
http://www.sciencedirect.com/science/article/pii/S2468501119300355
http://www.sciencedirect.com/science/article/pii/S2468501119300355
Autor:
Takashi K. Ito, Chenhao Lu, Jacob Khan, Quy Nguyen, Heather Z. Huang, Dayae Kim, James J. Phillips, Jo Tan, Yenna Lee, Tuyet Nguyen, Samy Khessib, Natalie Lim, Surapat Mekvanich, Joshua Oh, Victor V. Pineda, Weirong Wang, Alessandro Bitto, Jonathan Y. An, John F. Morton, Mitsutoshi Setou, Warren C. Ladiges, Matt Kaeberlein
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8566bb86a4243c964a82e3adc069bf9e
http://journal.frontiersin.org/article/10.3389/fgene.2017.00221/full
http://journal.frontiersin.org/article/10.3389/fgene.2017.00221/full
Autor:
Takashi K. Ito, Chenhao Lu, Jacob Khan, Quy Nguyen, Heather Z. Huang, Dayae Kim, James Phillips, Jo Tan, Yenna Lee, Tuyet Nguyen, Samy Khessib, Natalie Lim, Surapat Mekvanich, Joshua Oh, Victor V. Pineda, Weirong Wang, Alessandro Bitto, Jonathan Y. An, John F. Morton, Mitsutoshi Setou, Warren C. Ladiges, Matt Kaeberlein
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 8 (2017)
Frontiers in Genetics, Vol 8 (2017)
The inactivation of ribosomal protein S6 kinase 1 (S6K1) recapitulates aspects of caloric restriction and mTORC1 inhibition to achieve prolonged longevity in invertebrate and mouse models. In addition to delaying normative aging, inhibition of mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08444665379a5431d46be3c7a2c8fd07
Autor:
Alexander Mendenhall, Haeri Choi, Victor V. Pineda, Jane J. Kwon, Matthew M. Crane, Philip G. Morgan, Christopher F. Bennett, Joshua Russell, Shirley Park, Nikolay Burnaevskiy, Bryan Sands, Helen Vander Wende, Brian M. Wasko, Ryan Rossner, Carissa Perez Olsen, Matt Kaeberlein, Kathlyn Acosta, Alessandro Bitto, Gholamali Jafari, Marissa Simko, Shiwen Chen, Christine Chen
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 3, p e1006695 (2017)
PLoS Genetics, Vol 13, Iss 3, p e1006695 (2017)
Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538fcf7069a6ce045c86f01d780fb362
http://europepmc.org/articles/PMC5389855
http://europepmc.org/articles/PMC5389855
Autor:
Nicolas J LeTexier, Kathleen F. Kerr, Matt Kaeberlein, Takashi K. Ito, Herman Tung, Richard P. Beyer, Piper M. Treuting, Heather Z. Huang, Alessandro Bitto, Kaleb Smith, Belle Chen, Daniel J. Davis, Jessica M. Snyder, Catherine H. Gillespie, Nicholas Vizzini, Elissa Sutlief, Victor V. Pineda, Daniel Meza, Masanao Yajima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b2ac275aa54aedc7794b2861b9fd826
https://doi.org/10.7554/elife.16351.031
https://doi.org/10.7554/elife.16351.031
Autor:
Terry Gaasterland, Bryce L. Sopher, Audrey S. Dickey, Gavin Magnuson, Taiji Tsunemi, Kunal R. Sampat, Eduardo R. Lazarowski, Patrick Liu, Stephen K. Gilmore-Hall, Victor V. Pineda, Eliezer Masliah, Albert R. La Spada, Nicolas Arbez, Gene W. Yeo, Martin Arreola, Nicole S. Lomas, Mark Joseph Manalang Torres, Anthony B. Pinkerton, April L. Flores, Helen C. Miranda, Christopher A. Ross, Anne Buttgereit, Sergey S Akimov
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which encodes a polyglutamine tract in the HTT protein. We found that peroxisome proliferator-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0f029f51f2c94742e91edb056cc65e
Autor:
Andrew D. Strand, Gregory J. Morton, Eduardo R. Lazarowski, Randell T. Libby, Victor V. Pineda, Serge Luquet, Merle L. Gilbert, Terrence F. Satterfield, Richard P. Beyer, Ian R. Sweet, Theodor K. Bammler, Patrick Weydt, Michael W. Schwartz, Albert R. La Spada, Libin Cui, Dimitri Krainc, Annette C. Smith, Anne E. Torrence, Courtney N. Easley
Publikováno v:
Cell Metabolism. 4:349-362
Huntington's disease (HD) is a fatal, dominantly inherited disorder caused by polyglutamine repeat expansion in the huntingtin (htt) gene. Here, we observe that HD mice develop hypothermia associated with impaired activation of brown adipose tissue (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51896ce3f23bd653d7a7c94908d33fb
https://doi.org/10.1016/j.cmet.2006.10.004
https://doi.org/10.1016/j.cmet.2006.10.004
Autor:
Jeremy Celver, Lutz Birnbaumer, Hongbing Wang, Victor V. Pineda, Jaime Athos, Guylain Boulay, Daniel R. Storm, Danielle L. Ippolito
Publikováno v:
Neuron. 41(1):153-163
Stimulation of adenylyl cyclase in the hippocampus is critical for memory formation. However, generation of cAMP signals within an optimal range for memory may require a balance between stimulatory and inhibitory mechanisms. The role of adenylyl cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9c182a627adc60980e926fb81cb5d5