Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Victor Tsetlin"'
Autor:
Elena Gondarenko, Diana Mazur, Marina Masliakova, Yana Ryabukha, Igor Kasheverov, Yuri Utkin, Victor Tsetlin, Mikhail Shahparonov, Denis Kudryavtsev, Nadine Antipova
Publikováno v:
Toxins, Vol 16, Iss 2, p 80 (2024)
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, with a poor prognosis. GBM cells, which develop in the environment of neural tissue, often exploit neurotransmitters and their receptors to promote their own growth and invasi
Externí odkaz:
https://doaj.org/article/40a785a1aa7e4341893515938855d8bf
Publikováno v:
Toxins, Vol 16, Iss 2, p 100 (2024)
Phospholipases A2 (PLA2s) are a large family of snake toxins manifesting diverse biological effects, which are not always related to phospholipolytic activity. Snake venom PLA2s (svPLA2s) are extracellular proteins with a molecular mass of 13–14 kD
Externí odkaz:
https://doaj.org/article/8362104387e5432687c7745c3a97123d
Autor:
Marios Zouridakis, Athanasios Papakyriakou, Igor A. Ivanov, Igor E. Kasheverov, Victor Tsetlin, Socrates Tzartos, Petros Giastas
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/4289658000544441b1dd0d2ed13c20ae
Autor:
Victor Tsetlin, Yves Haufe, Valentina Safronova, Dmitriy Serov, PranavKumar Shadamarshan, Lina Son, Irina Shelukhina, Denis Kudryavtsev, Elena Kryukova, Igor Kasheverov, Annette Nicke, Yuri Utkin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits. While the α7 subtype is widely distributed in the mammalian brain
Externí odkaz:
https://doaj.org/article/ddee6ebe968d4ca3b82ed22a5d5b98d9
Autor:
Dilyara Nurkhametova, Andrei Siniavin, Maria Streltsova, Denis Kudryavtsev, Igor Kudryavtsev, Raisa Giniatullina, Victor Tsetlin, Tarja Malm, Rashid Giniatullin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Background: Extracellular ATP is a powerful trigger of neuroinflammation by activating immune cells via P2X7 receptors. Acetylcholine and nicotinic agonists inhibit ATP-triggered proinflammatory cytokines via the so-called “cholinergic anti-inflamm
Externí odkaz:
https://doaj.org/article/072a001fef0b4ea29e265f3460244beb
Autor:
Igor Kasheverov, Denis Kudryavtsev, Irina Shelukhina, Georgy Nikolaev, Yuri Utkin, Victor Tsetlin
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 189 (2022)
The purpose of our review is to briefly show what different compounds of marine origin, from low molecular weight ones to peptides and proteins, offer for understanding the structure and mechanism of action of nicotinic acetylcholine receptors (nAChR
Externí odkaz:
https://doaj.org/article/7bcbd9f3a9814d7ca09860ec493332e4
Autor:
Marios Zouridakis, Athanasios Papakyriakou, Igor A. Ivanov, Igor E. Kasheverov, Victor Tsetlin, Socrates Tzartos, Petros Giastas
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The α9 subunit of nicotinic acetylcholine receptors (nAChRs) exists mainly in heteropentameric assemblies with α10. Accumulating data indicate the presence of three different binding sites in α9α10 nAChRs: the α9(+)/α9(−), the α9(+)/α10(−
Externí odkaz:
https://doaj.org/article/08aafd21c40c44ef8301661b9d281c5f
Autor:
Denis Kudryavtsev, Anastasia Isaeva, Daria Barkova, Ekaterina Spirova, Renata Mukhutdinova, Igor Kasheverov, Victor Tsetlin
Publikováno v:
Molecules, Vol 26, Iss 5, p 1278 (2021)
Slow-channel congenital myasthenic syndromes (SCCMSs) are rare genetic diseases caused by mutations in muscle nicotinic acetylcholine receptor (nAChR) subunits. Most of the known SCCMS-associated mutations localize at the transmembrane region near th
Externí odkaz:
https://doaj.org/article/1883d9d82ce144528da8b6cc88ccab2a
Autor:
Lina Son, Elena Kryukova, Rustam Ziganshin, Tatyana Andreeva, Denis Kudryavtsev, Igor Kasheverov, Victor Tsetlin, Yuri Utkin
Publikováno v:
Toxins, Vol 13, Iss 2, p 164 (2021)
Cobra venoms contain three-finger toxins (TFT) including α-neurotoxins efficiently binding nicotinic acetylcholine receptors (nAChRs). As shown recently, several TFTs block GABAA receptors (GABAARs) with different efficacy, an important role of the
Externí odkaz:
https://doaj.org/article/77039c6ad3904f05b320a5a553d20605
Autor:
Vladislav V. Babenko, Rustam H. Ziganshin, Christoph Weise, Igor Dyachenko, Elvira Shaykhutdinova, Arkady N. Murashev, Maxim Zhmak, Vladislav Starkov, Anh Ngoc Hoang, Victor Tsetlin, Yuri Utkin
Publikováno v:
Biomedicines, Vol 8, Iss 8, p 249 (2020)
Feae’s viper Azemipos feae belongs to the Azemiopinae subfamily of the Viperidae family. The effects of Viperidae venoms are mostly coagulopathic with limited neurotoxicity manifested by phospholipases A2. From A. feae venom, we have earlier isolat
Externí odkaz:
https://doaj.org/article/a109caa8724842179684405e38f7df25