Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Victor T.W. Chan"'
Autor:
Yee W. Wong, Hong Wang, Zhi Gang Jiang, Bernard W. Futscher, Victor T.W. Chan, William S. Dalton
Publikováno v:
Biochemical and Biophysical Research Communications. 237:217-224
Decreased topoisomerase II (Topo II) activity results in resistance to antineoplastic agents targeting this enzyme. Dox1V derived from human multiple myeloma RPMI 8226 demonstrated a 4-fold resistance to doxorubicin in the absence of MDR1 overexpress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8eb2d1fe6d8d9eb1cc03b802549748
https://doi.org/10.1006/bbrc.1997.7115
https://doi.org/10.1006/bbrc.1997.7115
Autor:
Naiyer A. Rizvi, Julia Wong, Victor T.W. Chan, Gulshan Ara, Beverly A. Teicher, Joseph Paul Eder, Yee W. Wong, David Northey
Publikováno v:
Cancer chemotherapy and pharmacology. 42(4)
The DNA topoisomerases I and II are the target of several clinically important antineoplastic agents which produce DNA cleavage by stabilization of the covalent DNA-protein bond with resultant cell death after DNA synthesis is attempted. Depletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c8bef93f4a1e0bc99305eafb31664a
https://pubmed.ncbi.nlm.nih.gov/9744779
https://pubmed.ncbi.nlm.nih.gov/9744779
Publikováno v:
International Journal of Oncology.
Topoisomerase I inhibitors have shown positive effects in combination with radiation therapy in some studies. Normally oxygenated and hypoxic human MCF-7 breast carcinoma-cells were exposed to irinotecan (100 mu M or 250 mu M) or to SN-38 (10 mu M or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fd1d53e8cadf3c2c9432d4d4c78103
https://doi.org/10.3892/ijo.11.6.1235
https://doi.org/10.3892/ijo.11.6.1235