Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Victor Sukbong Hong"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1194 (2021)
Protein kinases regulate protein phosphorylation, which are involved in fundamental cellular processes such as inflammatory response. In this study, we discovered a novel multi-protein kinase inhibitor, KMU-1170, a derivative of indolin-2-one, and in
Externí odkaz:
https://doaj.org/article/b574e43d3c384438a3c413c13512c68e
Autor:
Hye Suk Baek, Hyeon Ji Min, Victor Sukbong Hong, Taeg Kyu Kwon, Jong Wook Park, Jinho Lee, Shin Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 5138 (2020)
PIM kinases, a small family of serine/threonine kinases, are important intermediates in the cytokine signaling pathway of inflammatory disease. In this study, we investigated whether the novel PIM kinase inhibitor KMU-470, a derivative of indolin-2-o
Externí odkaz:
https://doaj.org/article/fa8577c1e08948e694b1c2b6e5e046a4
Autor:
Yu-Kyoung Park, Jinho Lee, Victor Sukbong Hong, Jong-Soon Choi, Tae-Yoon Lee, Byeong-Churl Jang
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109344 (2014)
Differentiation of preadipocyte, also called adipogenesis, leads to the phenotype of mature adipocyte. Excessive adipogenesis, however, is largely linked to the development of obesity. Herein we investigated a library of 53 novel chemicals, generated
Externí odkaz:
https://doaj.org/article/678ce73cfd0a4c0095959f0a146a25d3
Publikováno v:
Bulletin of the Korean Chemical Society. 41:994-1001
Autor:
Ah Yeon Lee, Victor Sukbong Hong
Publikováno v:
Quantitative Bio-Science. 37:113-124
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(5)
The serum- and glucocorticoid-regulated kinase (SGK) family consists of three isoforms (SGK1, SGK2, and SGK3) that have been implicated in the regulation of tumor growth, metastasis, autophagy, and epithelial ion transport. SGK1 and SGK3 play essenti
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1194, p 1194 (2021)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1194, p 1194 (2021)
Protein kinases regulate protein phosphorylation, which are involved in fundamental cellular processes such as inflammatory response. In this study, we discovered a novel multi-protein kinase inhibitor, KMU-1170, a derivative of indolin-2-one, and in
Autor:
Taeg Kyu Kwon, Jinho Lee, Shin Kim, Jong-Wook Park, Hyeon Ji Min, Hye Suk Baek, Victor Sukbong Hong
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5138, p 5138 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 14
International Journal of Molecular Sciences
Volume 21
Issue 14
PIM kinases, a small family of serine/threonine kinases, are important intermediates in the cytokine signaling pathway of inflammatory disease. In this study, we investigated whether the novel PIM kinase inhibitor KMU-470, a derivative of indolin-2-o
Autor:
Jinho Lee, Masayuki Noguchi, Anil Kumar Yadav, Ik Soon Jang, Nam-Sook Park, Kunal N. More, Mahesh Ramalingam, Jae-Hoon Bae, Jong-Soon Choi, Byeong-Churl Jang, Hyo-Rim Cho, Junko Kano, Kyung-Bok Lee, Yu-Kyoung Park, Victor Sukbong Hong, David Bishop-Bailey
Publikováno v:
Journal of Cellular and Molecular Medicine
Meridianin C is a marine natural product known for its anti‐cancer activity. At present, the anti‐tumour effects of meridianin C on oral squamous cell carcinoma are unknown. Here, we investigated the effect of meridianin C on the proliferation of
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2513-2517
Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimiz