Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Victor Samokhvalov"'
Autor:
Victor Samokhvalov, K. Lockhart Jamieson, Ahmed M. Darwesh, Hedieh Keshavarz-Bahaghighat, Tim Y. T. Lee, Matthew Edin, Fred Lih, Darryl C. Zeldin, John M. Seubert
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Linoleic acid (18:2n6, LA) is an essential n-6 PUFA which is converted to arachidonic aci
Externí odkaz:
https://doaj.org/article/2414df085bd2474db0fdc6e2124d044d
Autor:
Tomoko Endo, Ahmed M. Darwesh, Victor Samokhvalov, Ayman O.S. El-Kadi, John M. Seubert, Ahmed A. El-Sherbeni, Kevin M. W. Khey, Masahiko Hirafuji, Takuji Machida
Publikováno v:
Cell Death Discovery, Vol 4, Iss 1, Pp 1-11 (2018)
Cell Death Discovery
Cell Death Discovery
Docosahexaenoic acid (DHA) and their CYP-derived metabolites, epoxydocosapentaenoic acids (EDPs), are important fatty acids obtained from dietary sources. While it is known that they have significant biological effects, which can differ between cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad21ea8f4d2cbb57648bd08a5d97a2d
http://link.springer.com/article/10.1038/s41420-018-0090-1
http://link.springer.com/article/10.1038/s41420-018-0090-1
Autor:
John M. Seubert, Kelvin E. Jones, Jonathan D. Schertzer, Ian M. Robertson, Carrie-Lynn M. Soltys, Victor Samokhvalov, David Fung, Nikole J. Byrne, Jody Levasseur, Neil Tyreman, Miranda M. Sung, Emmanuel Denou, Ty T. Kim, Jason R.B. Dyck
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H842-H853
We investigated whether treatment of mice with established pressure overload-induced heart failure (HF) with the naturally occurring polyphenol resveratrol could improve functional symptoms of clinical HF such as fatigue and exercise intolerance. C57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85237d828d93babd902995fe041fd073
https://doi.org/10.1152/ajpheart.00455.2016
https://doi.org/10.1152/ajpheart.00455.2016
Autor:
Zamaneh Kassiri, Carlos Fernandez-Patron, Abhijit Takawale, Gavin Y. Oudit, Dong Fan, John M. Seubert, Vaibhav B. Patel, Mengcheng Shen, Ratnadeep Basu, Victor Samokhvalov, Xiuhua Wang
Publikováno v:
Hypertension. 68:937-948
A disintegrin and metalloprotease-17 (ADAM17) belongs to a family of transmembrane enzymes, and it can mediate ectodomain shedding of several membrane-bound molecules. ADAM17 levels are elevated in patients with hypertrophic and dilated cardiomyopath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2071132449811397cda852ad5f0e8020
https://doi.org/10.1161/hypertensionaha.116.07566
https://doi.org/10.1161/hypertensionaha.116.07566
Publikováno v:
Canadian journal of physiology and pharmacology. 97(6)
Impaired mitochondrial function and activation of NLRP3 inflammasome cascade has a significant role in the pathogenesis of myocardial ischemia–reperfusion (IR) injury. The current study investigated whether eicosapentaenoic acid (EPA), docosahexaen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d04bc8dac89648257690884fd53dcb0
https://pubmed.ncbi.nlm.nih.gov/30326194
https://pubmed.ncbi.nlm.nih.gov/30326194
Publikováno v:
Pharmacologytherapeutics. 179
The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of enzymes, which are important in the metabolism of foreign and endogenous compounds. CYP isoforms metabolize a number of n-3 and n-6 polyunsaturated fatty acids (PUFA), inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252e50c298b3d8d858a7614bec803b83
https://pubmed.ncbi.nlm.nih.gov/28551025
https://pubmed.ncbi.nlm.nih.gov/28551025
Autor:
John M. Seubert, Nasser B. Alsaleh, Victor Samokhvalov, Rawabi Qadhi, Jérôme Bellenger, Haitham El-Sikhry
Publikováno v:
Toxicology Letters. 219:288-297
The importance of dietary polyunsaturated fatty acids (PUFAs) in the reduction of cardiovascular disease has been recognized for many years. Docosahexaenoic acid (22:6n3, DHA) is an n-3 PUFA known to affect numerous biological functions and provide c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0ff48c8d2424fd6260caa4c256b36a
https://doi.org/10.1016/j.toxlet.2013.03.010
https://doi.org/10.1016/j.toxlet.2013.03.010
Autor:
Woo Jung Cho, John M. Seubert, Haitham El-Sikhry, Edwin E. Daniel, Fenghua Yang, Victor Samokhvalov, Ketul R Chaudhary
Publikováno v:
Journal of Cardiovascular Pharmacology. 61:258-263
BACKGROUND: Caveolins (Cav) are structural proteins that insert into the plasma membrane to form caveolae that can bind molecules important in cardiac signal transduction and function. Cytochrome P450 epoxygenases can metabolize arachidonic acid to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58394fbec87524e406cae9a4d2b5b552
https://doi.org/10.1097/fjc.0b013e31827afcee
https://doi.org/10.1097/fjc.0b013e31827afcee
Autor:
John M. Seubert, Victor Samokhvalov, John R. Ussher, Wendy Keung, David G. Lopaschuk, Natasha Fillmore, Daniel Moroz, Gary D. Lopaschuk, Ian K.G. Armstrong
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 303:E1459-E1468
We previously showed that genetic inactivation of malonyl-CoA decarboxylase (MCD), which regulates fatty acid oxidation, protects mice against high-fat diet-induced insulin resistance. Development of insulin resistance has been associated with activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae19ebf9cbbae726e1b37c9b0170150
https://doi.org/10.1152/ajpendo.00018.2012
https://doi.org/10.1152/ajpendo.00018.2012
Autor:
Victor Samokhvalov, Kyra Lee, Zamaneh Kassiri, John M. Seubert, Woo Jung Cho, K. Lockhart Jamieson, Maria K. Akhnokh, Abhijit Takawale, Xiuhua Wang
Publikováno v:
Prostaglandinsother lipid mediators. 132
Background Pathophysiological responses, including cardiovascular complications, often alter with age. Cardioprotective effects of epoxyeicosatrienoic acids (EETs) toward acute myocardial ischemia-reperfusion injury have been well documented. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9589aea93d73567aaed690001eede056
https://pubmed.ncbi.nlm.nih.gov/28104457
https://pubmed.ncbi.nlm.nih.gov/28104457