Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Victor Prima"'
Autor:
Hazel C Levy, Danielle Hulvey, Laura Adamson-Small, Natacha Jn-Simon, Victor Prima, Scott Rivkees, Jacqueline A Hobbs
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228005 (2020)
Targeted gene therapy using recombinant adeno-associated virus (rAAV) vectors is a potential therapeutic strategy for treating cancer, and tissue-specific promoters may help with tissue targeting. Medullary thyroid carcinoma (MTC) is a disease of the
Externí odkaz:
https://doaj.org/article/30f8a00c966c4fcfb5360940bc435566
Autor:
Natacha Jn-Simon, Hazel C. Levy, Scott A. Rivkees, Danielle Hulvey, Laura Adamson-Small, Victor Prima, Jacqueline A. Hobbs
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228005 (2020)
PLoS ONE
PLoS ONE
Targeted gene therapy using recombinant adeno-associated virus (rAAV) vectors is a potential therapeutic strategy for treating cancer, and tissue-specific promoters may help with tissue targeting. Medullary thyroid carcinoma (MTC) is a disease of the
Autor:
Lyudmila N. Kaliberova, David T. Curiel, Victor Prima, Sergey A. Kaliberov, Sergei Kusmartsev
In recent years, it has been established that programmed cell death protein ligand 1 (PD-L1)–mediated inhibition of activated PD-1+ T lymphocytes plays a major role in tumor escape from immune system during cancer progression. Lately, the anti–PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae0b4284a7dd1af032875b81b5e8d3d
https://europepmc.org/articles/PMC5293015/
https://europepmc.org/articles/PMC5293015/
Publikováno v:
Journal of Neurotrauma. 30:1881-1887
Severe blast exposures are frequently complicated with fatal intracranial hemorrhages. However, many more sustain low level blasts without tissue damage detectable by brain imaging. To investigate effects of nonlethal blast on thrombin-related biomar
Autor:
Benedek Erdos, Philip J. Scarpace, Alexandra Sherman, Robert P. Yezierski, Nataliya Kirichenko, Firas Kobeissy, Stanislav I. Svetlov, Nihal Tümer, Kevin K.W. Wang, Victor Prima, Charles J. Vierck, Melissa A. Whidden
Publikováno v:
Neuroscience Letters. 544:62-67
Explosive overpressure brain injury (OBI) impacts the lives of both military and civilian population. We hypothesize that a single exposure to OBI results in increased hypothalamic expression of oxidative stress and activation of the sympatho-adrenal
Publikováno v:
Biomarkers. 18:242-249
Argininosuccinate synthase (ASS) plays an important role in regulating metabolic functions in mammals. We previously reported that hepatic ASS is released into circulation at very high concentrations in response to endotoxin and acute liver injury. W
Publikováno v:
International Immunopharmacology. 11:1180-1188
Lipopolysaccharide (LPS), a structural component of Gram-negative bacteria, is implicated in the pathogenesis of endotoxemia/sepsis and multi-organ injury, including liver damage. We have shown that argininosuccinate synthase (ASS), a hepatic enzyme
Autor:
Stephen P. Hunger, Victor Prima
Publikováno v:
Leukemia. 21:2470-2475
A variant t(1;19)(q23;p13.3) translocation creates reciprocal DAZAP1/MEF2D and MEF2D/DAZAP1 fusion genes that are expressed in acute lymphoblastic leukemia. We used retroviral gene transfer to ectopically express wild-type and chimeric DAZAP1 and MEF
Autor:
Nicholas Muzyczka, Victor Prima, Philip J. Scarpace, Oleg S. Gorbatyuk, Sergei Zolotukhin, Michael D. Tennant
Publikováno v:
Endocrinology. 145:2035-2045
Most obese animal models, whether associated with genetic, diet-induced, or age-related obesity, display pronounced leptin resistance, rendering leptin supplement therapy ineffective in treating obesity. Ciliary neurotrophic factor (CNTF) has been re
Autor:
Jared Wilsey, Philip J. Scarpace, Eugene W. Shek, Michael Matheny, Sergei Zolotukhin, Victor Prima
Publikováno v:
Gene Therapy. 9:1492-1499
Our purpose was to incorporate regulation into the recombinant adeno-associated virus encoding leptin by introducing a tet-inducible promotor. This system, TET-Ob, allows for control of leptin gene expression via doxycycline in drinking water. F344XB