Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Victor Ovchinnikov"'
Autor:
Simone Conti, Victor Ovchinnikov, Jonathan G. Faris, Arup K. Chakraborty, Martin Karplus, Kayla G. Sprenger
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4 (2022)
The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of
Externí odkaz:
https://doaj.org/article/1fb711c145304bb7a7da516379116abf
Autor:
Victor Ovchinnikov, Martin Karplus
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The elicitation of broadly neutralizing antibodies (bnAbs) is a major goal in the design of vaccines against rapidly-mutating viruses. In the case of influenza, many bnAbs that target conserved epitopes on the stem of the hemagglutinin protein (HA) h
Externí odkaz:
https://doaj.org/article/20919af4974945a58a8021039cd9f1d4
Autor:
Uddhav K. Shigdel, Victor Ovchinnikov, Seung-Joo Lee, Jenny A. Shih, Martin Karplus, Kwangho Nam, Gregory L. Verdine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
DNA glycosylases are lesion-specific enzymes that recognize specific nucleobase damages and catalyze their excision through cleavage of the glycosidic bond. Here, the authors present the crystal structures of human 8-oxoguanine (oxoG) DNA glycosylase
Externí odkaz:
https://doaj.org/article/60b39eb87d0b47c4a0f3eab9bd903e6e
Publikováno v:
Antibodies, Vol 11, Iss 3, p 51 (2022)
The accurate and efficient calculation of protein-protein binding affinities is an essential component in antibody and antigen design and optimization, and in computer modeling of antibody affinity maturation. Such calculations remain challenging des
Externí odkaz:
https://doaj.org/article/fc7fe7d53b6b4756b75a28e8208902e6
Publikováno v:
eLife, Vol 7 (2018)
Eliciting antibodies that are cross reactive with surface proteins of diverse strains of highly mutable pathogens (e.g., HIV, influenza) could be key for developing effective universal vaccines. Mutations in the framework regions of such broadly neut
Externí odkaz:
https://doaj.org/article/69892df03aa94b2f99c06bbbc7547df3
Autor:
Victor Ovchinnikov, Andriy Shevchenko
Publikováno v:
Journal of Chemistry, Vol 2013 (2013)
A cost-effective fabrication of random noble-metal nanostructures with a feature size of the order of 10 nm on a large-area dielectric substrate is described. The method combines dry etching of the substrate through a self-organized metal mask with a
Externí odkaz:
https://doaj.org/article/ed501d41513c4bb6959779063444a473
Autor:
Beata Dulko-Smith, Per Rogne, Christin Grundström, Pedro Ojeda-May, Apoorv Verma, Victor Ovchinnikov, Magnus Wolf-Watz, Uwe Sauer, Kwangho Nam, Ameeq Ui Mushtaq
Publikováno v:
Biochemistry. 60:2246-2258
Enzymes employ a wide range of protein motions to achieve efficient catalysis of chemical reactions. While the role of collective protein motions in substrate binding, product release, and regulation of enzymatic activity is generally understood, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1713e8d3c14fb749c39f4d3987d49d0
https://doi.org/10.1021/acs.biochem.1c00221
https://doi.org/10.1021/acs.biochem.1c00221
Publikováno v:
Materials Today: Proceedings. 38:1871-1874
The article discusses the technology of laser processing of VT6 titanium alloy as a technological operation to improve properties and structure. A promising direction for reducing roughness during laser hardening with reflow can be the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ea978c699a3d44c1c0222b2c3bc239
https://doi.org/10.1016/j.matpr.2020.08.494
https://doi.org/10.1016/j.matpr.2020.08.494
Publikováno v:
Materials Today: Proceedings. 38:1405-1408
The article presents studies of the effect of ion implantation on the physicomechanical properties of VT6 titanium alloy. The positive effect of ion implantation on the wear resistance and mechanical properties of a titanium alloy is shown. This work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f57586a6dba8a70f5fa6dfd88891bf43
https://doi.org/10.1016/j.matpr.2020.08.114
https://doi.org/10.1016/j.matpr.2020.08.114
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2405
Constrained peptides represent a relatively new class of biologic therapeutics, which have the potential to overcome several limitations of small-molecule drugs, and of designed antibodies. Because of their modest size, the rational design of such pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8578358fb25598bf29916e58bc3a2911
https://pubmed.ncbi.nlm.nih.gov/35298819
https://pubmed.ncbi.nlm.nih.gov/35298819