Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Victor Melendez"'
Publikováno v:
Pharmaceuticals, Vol 4, Iss 1, Pp 138-153 (2011)
In animal species and humans, artesunate (AS) undergoes extensive and complex biotransformation to an active metabolite, dihydroartemisinin (DHA). The bioequivalence of two intravenous AS pharmaceutical products with 5% NaHCO3 (China Formulation) or
Externí odkaz:
https://doaj.org/article/f9fe7db8c4994bdd95d3435ea955e226
Autor:
Roland A. Cooper, Susan E. Leed, Qiang Zeng, Kevin A. Reynolds, Lacy Gaynor-Ohnstad, Lisa Xie, Hsiuling Lin, Jason C. Sousa, Jianbing Mu, Heather Gaona, Raul Olmeda, Martin J. Smilkstein, Brett R. Bayles, Brittney Potter, Michael K. Riscoe, Richard J. Sciotti, Papireddy Kancharla, Yuexin Li, Brian Vesely, Sovitj Pou, Sean R. Marcsisin, Chau Vuong, Qigui Li, Brandon S. Pybus, Lisa Read, Victor Melendez, Norma Roncal, Thu Lan Luong, Diana Caridha, Chad C. Black, Rozalia A. Dodean, Jing Zhang, Kirk Butler, Patrick K Tumwebaze, Charles E. Bane, Philip J. Rosenthal, Stephanie A Rasmussen, Mara Kreishman-Deitrick, Jane Xu Kelly, Frida G. Ceja, Ping Zhang, Christina K. Nolan
Publikováno v:
J Med Chem
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for p
Autor:
Paul E Drawz, Malini DeSilva, Peter Bodurtha, Gabriela Vazquez Benitez, Anne Murray, Alanna M Chamberlain, R Adams Dudley, Stephen Waring, Anupam B Kharbanda, Daniel Murphy, Miriam Halstead Muscoplat, Victor Melendez, Karen L Margolis, Lynn McFarling, Roxana Lupu, Tyler N.A. Winkelman, Steve Johnson
Using vaccine data combined with electronic health records, we report that mRNA boosters provide greater protection than a two-dose regimen against SARS-CoV-2 infection and related hospitalizations. The benefit of a booster was more evident in the el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a7cc4541976f42c041f120f829e55bb
https://doi.org/10.1101/2021.12.23.21267853
https://doi.org/10.1101/2021.12.23.21267853
Autor:
Paul E Drawz, Malini DeSilva, Peter Bodurtha, Gabriela Vazquez Benitez, Anne Murray, Alanna M Chamberlain, R Adams Dudley, Stephen Waring, Anupam B Kharbanda, Daniel Murphy, Miriam Halstead Muscoplat, Victor Melendez, Karen L Margolis, Lynn McFarling, Roxana Lupu, Tyler N A Winkelman, Steven G Johnson
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 75(5)
Using vaccine data combined with electronic health records, we report that mRNA boosters provide greater protection than a 2-dose regimen against SARS-CoV-2 infection and related hospitalizations. The benefit of a booster was more evident in the elde
Autor:
Victor Melendez-Elizondo, Carla West-Coffee, Stanley P. L. Leong, Niloofar Fadaki, James E. Cleaver, Alejandra Gutierrez-Range, Mohammed Kashani-Sabet, Michael Chen, Ying Lu, Suresh Thummala, Andrei Rios-Cantu
Publikováno v:
Clinical & experimental metastasis, vol 34, iss 5
Melanoma patients with additional positive lymph nodes in the completion lymph node dissection (CLND) following a positive sentinel lymph node (SLN) biopsy would have a poorer prognosis than patients with no additional positive lymph nodes. We hypoth
Autor:
Yuexin Li, Kirk Butler, Brittney Potter, Qigui Li, Papireddy Kancharla, Roland A. Cooper, Thu Lan Luong, Heather Gaona, Jing Zhang, Richard J. Sciotti, Brian Vesely, Chau Vuong, Qiang Zeng, Sean R. Marcsisin, Michael K. Riscoe, Diana Caridha, Jason C. Sousa, Rolf W. Winter, Norma Roncal, Christina K. Nolan, Lisa Read, Rozalia A. Dodean, Lisa Xie, Lacy Gaynor-Ohnstad, Stephanie J. Huezo, Susan E. Leed, Hsiuling Lin, John C. Tan, Martin J. Smilkstein, Stephanie A Rasmussen, Jane Xu Kelly, Ping Zhang, Chad C. Black, Melissa T. Stephens, Mara Kreishman-Deitrick, Raul Olmeda, Victor Melendez, Sovitj Pou, Charles E. Bane
Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351c0f6f16032d54883ac7a5e8be555b
https://europepmc.org/articles/PMC6822569/
https://europepmc.org/articles/PMC6822569/
Autor:
Larry A. Walker, Rajnish Sahu, Gregory A. Reichard, H. M. T. Bandara Herath, N. P. Dhammika Nanayakkara, Babu L. Tekwani, Frank R. Fronczek, Anchalee Tungtaeng, James D. McChesney, Paul C. Baresel, Kristina S. Wickham, Yvonne Van Gessel, Victor Melendez, Rosemary Rochford, Marilyn S. Bartlett, Colin Ohrt, Montip Gettayacamin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4737-4744
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria. PQ is
Autor:
Norma Roncal, Patricia J. Lee, Jing Zhang, Qiang Zeng, Michael P. Kozar, Ping Zhang, Victor Melendez, Qigui Li, Hongxing Wang, Lisa Xie, Sean Reyes, Mark Hickman
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 10:57-65
Decoquinate has potent activity against both Plasmodium hepatic development and red cell replication when tested in vitro . Decoquinate, however, is practically insoluble in water. To achieve its maximal in vivo efficacy, we generated nanoparticle fo
Autor:
Victor Melendez, Frank C. Tortella, Andrea Mountney, Xi-Chun M. Lu, Deborah A. Shear, Brittney Potter, Jason C. Sousa, Sean R. Marcsisin
Publikováno v:
Journal of Neurotrauma. 30:1973-1982
Acute seizures frequently occur following severe traumatic brain injury (TBI) and have been associated with poor patient prognosis. Silent or nonconvulsive seizures (NCS) manifest in the absence of motor convulsion, can only be detected via continuou
Autor:
Jay Moon, Franklyn Ngundam, Erin Milner, Erin Harris, Sandi Parriott, Richard J. Sciotti, Brittney Potter, Qigui Li, Patricia J. Lee, Michael T. O’Neil, Michael P. Kozar, Sean Gardner, Diana Caridha, Jennifer M. Auschwitz, Anchalee Tangteung, Kristina Grauer, Mark Hickman, Geoffrey S. Dow, Susan E. Leed, Jason C. Sousa, Brandon S. Pybus, Victor Melendez
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 37:17-22
Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models. However, the low plasma levels and short half life of the drug do not adequately explain its in vivo efficacy. We synthesized most of the known metabolites of ket