Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Victor M. Matias-Barrios"'
Autor:
Victor M. Matias-Barrios, Xuesen Dong
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 94 (2023)
DNA topoisomerase II (Top2) is essential for all eukaryotic cells in the regulation of DNA topology through the generation of temporary double-strand breaks. Cancer cells acquire enhanced Top2 functions to cope with the stress generated by transcript
Externí odkaz:
https://doaj.org/article/4e528545670f4702bbb1da56558acbc5
Autor:
Victor M. Matias-Barrios, Mariia Radaeva, Yi Song, Zaccary Alperstein, Ahn R. Lee, Veronika Schmitt, Joseph Lee, Fuqiang Ban, Ning Xie, Jianfei Qi, Nada Lallous, Martin E. Gleave, Artem Cherkasov, Xuesen Dong
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause cancer cell death by inducing DNA damage, which mechanism of action is also associated with serious side effects such as secondary malignancy and cardiotoxicity. In
Externí odkaz:
https://doaj.org/article/e540c6f93470479eae4a4308cd7ca9c6
Autor:
Nada Lallous, Hans Adomat, Joseph Lee, Mariia Radaeva, Chia-Hao Ho, Xuesen Dong, Artem Cherkasov, Victor M. Matias-Barrios
Publikováno v:
Cancers, Vol 13, Iss 3675, p 3675 (2021)
Cancers
Volume 13
Issue 15
Cancers
Volume 13
Issue 15
Simple Summary DNA topoisomerase II (TOP2) is a drug target for many types of cancers. However, clinically used TOP2 inhibitors not only kill cancer cells, but also damage normal cells, and can even give rise to other types of cancers. To discover ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d42bfccbf31628be2fdff1567380539
https://www.mdpi.com/2072-6694/13/15/3675
https://www.mdpi.com/2072-6694/13/15/3675