Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Victor M. Garsky"'
Autor:
Annie Liang, Michael D. Leitl, Stefanie A. Kane, Matthew J. Cato, Victor M. Garsky, Mark O. Urban, Robert H. Spencer, Jerzy Karczewski, Sean P. Cook
Publikováno v:
British Journal of Pharmacology. 161:950-960
BACKGROUND AND PURPOSE Inflammatory pain is triggered by activation of pathways leading to the release of mediators such as bradykinin, prostaglandins, interleukins, ATP, growth factors and protons that sensitize peripheral nociceptors. The activatio
Autor:
Victor M. Garsky, Melanie Horton, Michael P. Citron, Joseph G. Joyce, Jiang Fan, Tong-Ming Fu, Danilo R. Casimiro, John W. Shiver, Xiaoping Liang, Qinjian Zhao, Daniel C. Freed
Publikováno v:
Virology. 385:218-226
M2 protein of influenza A virus has been implicated as a target for vaccines with broad cross-strain coverage. Studies in small animal models have shown that antibody responses induced by 23-mer M2 peptide vaccines can provide protection against infl
Autor:
Craig T. Przysiecki, Bei Wang, Roxana Ionescu, Robert Troutman, Jiang Fan, Yvette Rippeon, Li Shi, Elizabeth Flanagan, John W. Shiver, Xiaoping Liang, Victor M. Garsky
Publikováno v:
Journal of Pharmaceutical Sciences. 95:70-79
We report the preparation and the immunogenicity of a conjugate vaccine obtained by chemically conjugating a variant of the extracellular peptide fragment of influenza type A M2 protein to the human papillomavirus (HPV) viruslike particle (VLP). Conj
Autor:
Paul M. Keller, John W. Shiver, Victor M. Garsky, Mary-Ellen Davies, Roxana Ionescu, Jiang Fan, Jon H. Condra, Helen C. Perry, Melanie Horton, Li Shi, Jason J. Z. Liao, Gwen J Heidecker, Xiaoping Liang, Michael Chastain, Emilio A. Emini, Yvette Rippeon, Joseph G. Joyce, Tong-Ming Fu, Michael P. Citron, Craig T. Przysiecki
Publikováno v:
Vaccine. 22:2993-3003
A universal influenza virus vaccine that does not require frequent updates and/or annual immunizations will offer significant advantages over current seasonal flu vaccines. The highly conserved influenza virus A M2 membrane protein has been previousl
Autor:
Craig A. Coburn, Victor M. Garsky, Joseph P. Vacca, Satendra Singh, M. Katharine Holloway, Daria J. Hazuda, Michael W. Pennington, Ming-Tain Lai, Michael J. Bogusky, Stephen F. Brady, Ming-Chih Crouthamel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:601-604
An effective approach for enhancing the selectivity of beta-site amyloid precursor protein cleaving enzyme (BACE 1) inhibitors is developed based on the unique features of the S1' pocket of the enzyme. A series of low molecular weight (
Autor:
Georgia B. McGaughey, Joseph G. Joyce, Xiaoping Liang, Renee Danzeisen, Michael W. Miller, Roger M. Freidinger, Victor M. Garsky, John W. Shiver, Michael P. Citron, Michael J. Bogusky, W M Hurni
Publikováno v:
Biochemistry. 42:3214-3223
The human immunodeficiency virus type I (HIV-1) transmembrane glycoprotein gp41 mediates viral entry through fusion of the target cellular and viral membranes. A segment of gp41 containing the sequence Glu-Leu-Asp-Lys-Trp-Ala has previously been iden
Autor:
William M. Hurni, Paul M. Keller, Michael J. Bogusky, Renee Danzeisen, Xiaoping Liang, John W. Shiver, Victor M. Garsky, Joseph G. Joyce, Michael D. Miller, Michael P. Citron
Publikováno v:
Journal of Biological Chemistry. 277:45811-45820
The synthetic peptide DP178, derived from the carboxyl-terminal heptad repeat region of human immunodeficiency virus type 1 GP41 protein is a potent inhibitor of viral-mediated fusion and contains the sequence ELDKWA, which constitutes the recognitio
Autor:
Culberson Jc, Victor M. Garsky, Kenneth S. Koblan, Pessi A, Wallace A, Steven M. Pitzenberger, Michael J. Bogusky
Publikováno v:
The Journal of Peptide Research. 54:66-73
Farnesyl-protein transferase (FPTase) catalyzes the posttranslational farnesylation of the cysteine residue located in the C-terminal tetrapeptide of the Ras oncoprotein. Prenylation of this residue is essential for membrane association and cell-tran
Autor:
Lois K. Miller, Vivien A. Warren, Jeffrey W. Warmke, McHardy M. Smith, Victor M. Garsky, Grigori G. Prikhod'ko, Charles J. Cohen, Holly J.R. Popham, Thomas J. Felcetto, Dan A. Ostlind
Publikováno v:
Biological Control. 12:66-78
Previously, we have described the properties of recombinant baculoviruses expressing three chimeric genes, mag4, sat2, and ssh1, that encode secretable insect selective sodium channel toxins, μ-Aga-IV from the spider Agelenopsis aperta, As II from t
Publikováno v:
Journal of Biological Chemistry. 271:31957-31963
Site-specific substitutions of as few as four amino acids (M46I/L63P/V82T/I84V) of the human immunodeficiency virus type 1 (HIV-1) protease engenders cross-resistance to a panel of protease inhibitors that are either in clinical trials or have recent