Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Victor L.J. Tybulewicz"'
Autor:
Phillip M. Muza, Daniel Bush, Marta Pérez-González, Ines Zouhair, Karen Cleverley, Miriam L. Sopena, Rifdat Aoidi, Steven J. West, Mark Good, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher, Pishan Chang
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106073- (2023)
Summary: The Dp(10)2Yey mouse carries a ∼2.3-Mb intra-chromosomal duplication of mouse chromosome 10 (Mmu10) that has homology to human chromosome 21, making it an essential model for aspects of Down syndrome (DS, trisomy 21). In this study, we inv
Externí odkaz:
https://doaj.org/article/3fbb7b3045ba4d09b1a49b9bef3ec9e9
Autor:
Da Ma, Manuel J. Cardoso, Maria A. Zuluaga, Marc Modat, Nick M. Powell, Frances K. Wiseman, Jon O. Cleary, Benjamin Sinclair, Ian F. Harrison, Bernard Siow, Karteek Popuri, Sieun Lee, Joanne A. Matsubara, Marinko V. Sarunic, Mirza Faisal Beg, Victor L.J. Tybulewicz, Elizabeth M.C. Fisher, Mark F. Lythgoe, Sebastien Ourselin
Publikováno v:
NeuroImage, Vol 223, Iss , Pp 117271- (2020)
Down Syndrome is a chromosomal disorder that affects the development of cerebellar cortical lobules. Impaired neurogenesis in the cerebellum varies among different types of neuronal cells and neuronal layers. In this study, we developed an imaging an
Externí odkaz:
https://doaj.org/article/11d3cf7d4fa743c7b2d3061b08f2b512
Autor:
Pishan Chang, Daniel Bush, Stephanie Schorge, Mark Good, Tara Canonica, Nathanael Shing, Suzanna Noy, Frances K. Wiseman, Neil Burgess, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Summary: Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associ
Externí odkaz:
https://doaj.org/article/0726a09e79f942f28afb7ca0608d677c
Autor:
Alain D. Dekker, Yannick Vermeiren, Christelle Albac, Eva Lana-Elola, Sheona Watson-Scales, Dorota Gibbins, Tony Aerts, Debby Van Dam, Elizabeth M.C. Fisher, Victor L.J. Tybulewicz, Marie-Claude Potier, Peter P. De Deyn
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 235-244 (2017)
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in people with Down syndrome (DS, trisomy 21). Because of the limited availability of human post-mortem tissue, DS mouse models are of great interest to
Externí odkaz:
https://doaj.org/article/cd6d4a7b4bcd47e9b878a2463ab19abb
Autor:
Tyler Jacks, Victor L.J. Tybulewicz, Anthony J. Capobianco, David A. Tuveson, Matthew S. Eckman, Alejandro Sweet-Cordero, Carla F. Bender Kim, Kevin M. Haigis, Linda Hanlon, Marita J. Walmsley, Joseph L. Kissil
Supplementary Figure 1 from Requirement for Rac1 in a K-ras–Induced Lung Cancer in the Mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1f9d983ad257e8734f8ca39a8407f6
https://doi.org/10.1158/0008-5472.22367508.v1
https://doi.org/10.1158/0008-5472.22367508.v1
Autor:
Tyler Jacks, Victor L.J. Tybulewicz, Anthony J. Capobianco, David A. Tuveson, Matthew S. Eckman, Alejandro Sweet-Cordero, Carla F. Bender Kim, Kevin M. Haigis, Linda Hanlon, Marita J. Walmsley, Joseph L. Kissil
Given the prevalence of Ras mutations in human cancer, it is critical to understand the effector pathways downstream of oncogenic Ras leading to transformation. To directly assess the requirement for Rac1 in K-ras–induced tumorigenesis, we employed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a64da1874672719bc39d1f484f7a46
https://doi.org/10.1158/0008-5472.c.6495576
https://doi.org/10.1158/0008-5472.c.6495576
Autor:
Phillip Muza, Daniel Bush, Marta Pérez-González, Ines Zouhair, Karen Cleverley, Miriam Llorian Sopena, Rifdat Aoidi, Steven J. West, Mark Good, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth MC Fisher, Pishan Chang
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c3206ba2085dc7ed16e0d3fd2154027
https://doi.org/10.2139/ssrn.4266339
https://doi.org/10.2139/ssrn.4266339
Autor:
Jane Forsyth, David R. Phillips, Mark H. Ginsberg, Paul E. Hughes, Kathleen Ministri, Martin R Turner, Victor L.J. Tybulewicz, Debbie A. Law, Lisa Nannizzi-Alaimo, Sanford J. Shattil
Publikováno v:
Blood. 93:2645-2652
Agonists induce inside-out IIbβ3signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling resulting in further platelet stimulation. Because the Syk tyrosine kinase is activated during both pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62970ad35ec6cf436694726f2501a84a
https://doi.org/10.1182/blood.v93.8.2645
https://doi.org/10.1182/blood.v93.8.2645
Autor:
Debbie A. Law, Lisa Nannizzi-Alaimo, Kathleen Ministri, Paul E. Hughes, Jane Forsyth, Martin Turner, Sanford J. Shattil, Mark H. Ginsberg, Victor L.J. Tybulewicz, David R. Phillips
Publikováno v:
Blood. 93:2645-2652
Agonists induce inside-out IIbβ3signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling resulting in further platelet stimulation. Because the Syk tyrosine kinase is activated during both pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b018259b857cd695dd750327500400f
https://doi.org/10.1182/blood.v93.8.2645.408k13_2645_2652
https://doi.org/10.1182/blood.v93.8.2645.408k13_2645_2652
Publisher Summary This chapter discusses the structure and assembly of F1FO ATPase complex. Bacterial proton translocating ATP-synthase couples the electrochemical potential difference for H+ across the cytoplasmic membrane to synthesis of ATP from A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4feebdc60169caa2688d00b441d77cfc
https://doi.org/10.1016/b978-0-444-80540-9.50024-8
https://doi.org/10.1016/b978-0-444-80540-9.50024-8