SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.

Autor: Marius Walter, Irene P Chen, Albert Vallejo-Gracia, Ik-Jung Kim, Olga Bielska, Victor L Lam, Jennifer M Hayashi, Andrew Cruz, Samah Shah, Frank W Soveg, John D Gross, Nevan J Krogan, Keith R Jerome, Birgit Schilling, Melanie Ott, Eric Verdin

Publikováno v: PLoS Pathogens, Vol 18, Iss 9, p e1010811 (2022)

SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits exoribonuclease and N7-methyltransferase activities. Protein-interactome

Externí odkaz: https://doaj.org/article/19538024418c4582aee777208e569149

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

Autor: Jessica K. Peters, Natalia Jura, Aye C. Thwin, Mehdi Bouhaddou, Fei Li, Jocelyne Lopez, Yang Li, Kuei-Ho Chen, Erron W. Titus, Huong T. Kratochvil, Victor L Lam, Christian B. Billesbølle, Tristan W. Owens, Raphael Trenker, Axel F. Brilot, Danielle L. Swaney, Ursula Schulze-Gahmen, Feng Wang, Gregory E. Merz, Jen Chen, Amy Diallo, Yang Zhang, Adam Frost, Soumya G. Remesh, Junrui Li, Edmond Linossi, Fengbo Zhou, Maliheh Safari, Yifan Cheng, Henry C. Nguyen, Andrea Fossati, Devan Diwanji, Evelyn Hernandez, Aashish Manglik, Nevan J. Krogan, Iris D. Young, Jianhua Zhao, Kyle E. Lopez, Alexandrea N. Rizo, Megan Lo, Thomas H. Pospiech, Gwendolyn M. Jang, Y. Li, Sergei Pourmal, Yuan Zhou, Miles Sasha Dickinson, Un Seng Chio, Kaihua Zhang, Caleigh M. Azumaya, Michael D Paul, Oren S. Rosenberg, Yanxin Liu, Tsz Kin Martin Tsui, Carlos Nowotny, Kate Kim, Kliment A. Verba, Loan Doan, Zanlin Yu, Adrian Pelin, Mariano C Tabios, Lorena Zuliani-Alvarez, Daniel R. Southworth, Melody G. Campbell, Ming Sun, Adamo Mancino, Kaitlin Schaefer, Frank R. Moss, Daniel Asarnow, Meghna Gupta, James S. Fraser, Komal Ishwar Pawar, Amber M. Smith, Robert M. Stroud, Tanja Kortemme, Cristina Puchades, Michelle Moritz, Nadia Herrera, Eric Tse, Mingliang Jin, David A. Agard

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv, vol 2, iss 05-19
Research Square

The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis of those functions, remain unknown. Here, we report an atomic model for full-length Nsp2 obtained by combining cryo-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8c3bdd782cfa56f525ccd0d1740780
https://pubmed.ncbi.nlm.nih.gov/34013269

RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus

Autor: Victor L. Lam, Christopher S. Sullivan, Rodney P. Kincaid, Glenn Randall, Rachel Chirayil

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 115(32)

Seventy percent of people infected with hepatitis C virus (HCV) will suffer chronic infection, putting them at risk for liver disease, including hepatocellular carcinoma. The full range of mechanisms that render some people more susceptible to chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584db76d41fa48c3448213859aa00dfc
https://pubmed.ncbi.nlm.nih.gov/30038017