Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

Autor: Yang Zhang, Gerd Bobe, Cristobal L Miranda, Malcolm B Lowry, Victor L Hsu, Christiane V Lohr, Carmen P Wong, Donald B Jump, Matthew M Robinson, Thomas J Sharpton, Claudia S Maier, Jan F Stevens, Adrian F Gombart

Publikováno v: eLife, Vol 10 (2021)

We previously reported xanthohumol (XN), and its synthetic derivative tetrahydro-XN (TXN), attenuates high-fat diet (HFD)-induced obesity and metabolic syndrome in C57Bl/6J mice. The objective of the current study was to determine the effect of XN an

Externí odkaz: https://doaj.org/article/2429acd383fb4e10be829a3c44468c2f

Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies

Autor: William H. Bisson, Victor L. Hsu, Claudia S. Maier, Adrian F. Gombart, Liping Yang, Yan Campbell, Jan F. Stevens, Yuan Jiang, David Broderick

Publikováno v: Biochimica et biophysica acta. 1864(12)

We report on the molecular interactions of the farnesoid X receptor (FXR) with prenylflavonoids, an emerging class of FXR modulators. FXR is an attractive therapeutic target for mitigating metabolic syndromes (MetS) because FXR activates the inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2e3472cf6db845c7eb7eefb5574131
https://pubmed.ncbi.nlm.nih.gov/27596062

The extended left-handed helix: A simple nucleic acid-binding motif

Autor: Joshua M. Hicks, Victor L. Hsu

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 55:330-338

The poly-proline type II extended left-handed helical structure is well represented in proteins. In an effort to determine the helix's role in nucleic acid recognition and binding, a survey of 258 nucleic acid-binding protein structures from the Prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f40df5e79f21ed94700c217b70b2c9
https://doi.org/10.1002/prot.10630

Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: Insights into the antagonism of the hypolipidemic agent Z-guggulsterone

Autor: Victor L. Hsu, Claudia S. Maier, David Broderick, Yuan Jiang, Liping Yang

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce689c311f68b3c21985479a6364521
https://europepmc.org/articles/PMC4137978/

Leaf surface flavonoids of Chrysothamnus

Autor: Jan F. Stevens, Max L. Deinzer, Victor L. Hsu, Scott D. Sundberg, Eckhard Wollenweber, Monika Ivancic

Publikováno v: Phytochemistry, 51, 771-780. Elsevier Limited
Stevens, J F, Wollenweber, E, Ivancic, M, Hsu, V L, Sundberg, S & Deinzer, M L 1999, ' Leaf surface flavonoids of Chrysothamnus ', Phytochemistry, vol. 51, pp. 771-780 . https://doi.org/10.1016/S0031-9422(99)00110-7

Twenty-six flavonoid aglycones have been identified from eight plants covering three species of Chrysothamnus that were collected in eastern Oregon. The flavonoids were identified by NMR spectroscopy, tandem mass spectrometry and co-TLC with authenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8329ef293145f186f4073d5121430f
https://research.vu.nl/en/publications/870d2e8f-2aca-46b9-b2a0-d7ffe21734bb