Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Victor Kotelianski"'
Autor:
Pei-Yu Chen, Lingfeng Qin, Carmen Barnes, Klaus Charisse, Tai Yi, Xinbo Zhang, Rahmat Ali, Pedro P. Medina, Jun Yu, Frank J. Slack, Daniel G. Anderson, Victor Kotelianski, Fen Wang, George Tellides, Michael Simons
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1684-1696 (2012)
Maintenance of normal endothelial function is critical to various aspects of blood vessel function, but its regulation is poorly understood. In this study, we show that disruption of baseline fibroblast growth factor (FGF) signaling to the endotheliu
Externí odkaz:
https://doaj.org/article/db1a80d775ca4e47adf26233e916f348
Autor:
Joseph Chiesa, Amy Simon, Jeffrey Cehelsky, Brian Bettencourt, Kevin Fitzgerald, Valerie A. Clausen, Jessica E. Sutherland, Maria Frank-Kamenetsky, Renta Hutabarat, Jay D. Horton, JM Ritter, Timothy Mant, Svetlana Shulga-Morskaya, Verena Karsten, Malathy Munisamy, Abigail Liebow, Akshay Vaishnaw, Jared Gollob, Victor Kotelianski, Saraswathy V. Nochur
Publikováno v:
The Lancet. 383:60-68
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that loss-of-function mutations in PCSK9 result in reduced plasma LDL cholesterol and decreased risk of coronary h
Autor:
Christian Wolfrum, Nikolay V. Dokholyan, Gang Wang, Valerie A. Clausen, Julia Hettinger, Svetlana Shulga Morskaya, Qianfan Wang, Joshua Brodsky, Verbena Kosovrasti, Xuemei Zhang, Dinah W.Y. Sah, Mike Meys, Kallanthottathil G. Rajeev, Yupang Fang, Muthiah Manoharan, Jennifer Sharman, Martin Maier, Feng Ding, Mariano Severgnini, Victor Kotelianski, Lubomir Tchangov, Renta Hutabarat, Chang Geng Peng, Robert Li, Tim Racie, Lubomir Nechev, James Butler, Tomoko Nakayama, Scott A Barros, Alfica Sehgal, Markus Stoffel
Publikováno v:
Molecular Therapy, 20 (8)
Molecular Therapy
MOLECULAR THERAPY
Molecular Therapy
MOLECULAR THERAPY
Therapeutics based on RNA interference (RNAi) have emerged as a potential new class of drugs for treating human disease by silencing the target messenger RNA (mRNA), thereby reducing levels of the corresponding pathogenic protein. The major challenge
Autor:
Wenjun Zhang, Martin E. Maier, Muthiah Manoharan, Lubomir Nechev, Victor Kotelianski, Dinah W.Y. Sah, Jason Costigan, Pei Ge, Yupeng Fan, William Querbes, Klaus Charisse
Publikováno v:
Oligonucleotides. 19:23-30
The most significant challenge remaining in the development of small interfering RNAs (siRNAs) as a new class of therapeutic drugs is successful delivery in vivo. The majority of reported studies describing delivery of siRNA or short hairpin RNA (shR
Autor:
Xinbo Zhang, Daniel G. Anderson, Victor Kotelianski, Pei-Yu Chen, Carmen Barnes, Pedro P. Medina, Fen Wang, George Tellides, Tai Yi, Jun Yu, Rahmat Ali, Lingfeng Qin, Klaus Charisse, Michael Simons, Frank J. Slack
Publikováno v:
Elsevier
Cell Reports, Vol 2, Iss 6, Pp 1684-1696 (2012)
Cell Reports, Vol 2, Iss 6, Pp 1684-1696 (2012)
SummaryMaintenance of normal endothelial function is critical to various aspects of blood vessel function, but its regulation is poorly understood. In this study, we show that disruption of baseline fibroblast growth factor (FGF) signaling to the end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40218fc69fa2470161532e305a0416f
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0001-5629-4798
Autor:
Elena Aikawa, Hiroyuki Yamazaki, Daiju Fukuda, Tatiana Novobrantseva, Ralph Weissleder, Kevin Croce, Filip K. Swirski, Aleksey Chudnovskiy, Jon C. Aster, Hideo Yagita, Masanori Aikawa, Victor Kotelianski, Cem Z. Görgün, Gökhan S. Hotamisligil
Publikováno v:
Proceedings of the National Academy of Sciences. 109
Atherosclerosis and insulin resistance are major components of the cardiometabolic syndrome, a global health threat associated with a systemic inflammatory state. Notch signaling regulates tissue development and participates in innate and adaptive im
Autor:
Ivanka Toudjarska, Martin Maier, Lubomir Nechev, John P. DeVincenzo, Rene Alvarez, Victor Kotelianski, Svetlana Shulga Morskaya, Ralph A. Tripp, Ingo Roehl, Mark Van Ranst, Muthiah Manoharan, Jeffrey S. Kahn, Philipp Hadwiger, Mathias John, Rachel Meyers, Todd Borland, Rick Martinello, Rajendra K. Pandey, Sayda Elbashir
Publikováno v:
Antimicrobial Agents and Chemotherapy
We describe the design and characterization of a potent human respiratory syncytial virus (RSV) nucleocapsid gene-specific small interfering RNA (siRNA), ALN-RSV01. In in vitro RSV plaque assays, ALN-RSV01 showed a 50% inhibitory concentration of 0.7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21326bd487d5d392841c2ced60d84c81
https://europepmc.org/articles/PMC2737834/
https://europepmc.org/articles/PMC2737834/
Autor:
Kevin Fitzgerald, Maria Frank-Kamenetsky, Tracy S Zimmermann, Jay Horton, Akin Akinc, Birgit Bramlage, David Bumcrot, Jens Harborth, Matthias John, Victor Kotelianski, Muthiah Manoharan, Martin Maier, Lubomir Nechev, Timothy Racie, Ingo Roehl, Stephan Seiffert, Sumi Shanmugam, Jurgen Soutschek, Ivanka Toudjarska, Hans-Peter Vornlocher, William Zedalis
Publikováno v:
Circulation. 116
Delivery of small interfering RNAs (siRNAs) in vivo , using clinically relevant modes of administration, is critical for the advancement of RNA interference (RNAi) therapeutics. In this work, we demonstrate systemic delivery of siRNAs and potent in v
Autor:
Steven J. Ray, Jonathan Rebhahn, Victor Kotelianski, Sarah J. Austin, Antonin Defougerolles, Martin V. Richter, Tim R. Mosmann, David J. Topham, Humphrey Gardner, Timothy J. Chapman
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(7)
Most viral infections occur in extralymphoid tissues, yet the mechanisms that regulate lymphocytes in these environments are poorly understood. One feature common to many extralymphoid environments is an abundance of extracellular matrix. We have stu
Autor:
Akin Akinc, Chris Zurenko, Victor Kotelianski, William Querbes, Julia Hettinger, June Qin, Satya Kuchimanchi, Klaus Charisse, Javid Moslehi, Kevin Fitzgerald, Dinah W.Y. Sah, Roman L. Bogorad, Jamie Wong, William G. Kaelin
Publikováno v:
Blood. 118:3161-3161
Abstract 3161 Anemia in chronic kidney disease patients due to impaired renal production of erythropoietin (EPO) and insufficient erythropoiesis is a significant public health problem. One approach to compensate for the low EPO levels in patients wit