Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Victor Klimyuk"'
Autor:
Gwenn Waerlop, Yorick Janssens, Bart Jacobs, Franziska Jarczowski, André Diessner, Geert Leroux-Roels, Victor Klimyuk, Isabel Leroux-Roels, Frank Thieme
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The development of an efficacious vaccine against norovirus is of paramount importance given its potential to reduce the global burden of norovirus-associated morbidity and mortality. Here, we report a detailed immunological analysis of a phase I, do
Externí odkaz:
https://doaj.org/article/f7335b481858407fbb8da1fd8c01564b
Autor:
Isabel Leroux-Roels, Cathy Maes, Jasper Joye, Bart Jacobs, Franziska Jarczowski, André Diessner, Yorick Janssens, Gwenn Waerlop, Kirsi Tamminen, Suvi Heinimäki, Vesna Blazevic, Geert Leroux-Roels, Victor Klimyuk, Hiroshi Adachi, Kazuyuki Hiruta, Frank Thieme
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Noroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide and a safe and effective vaccine is needed. Here, a phase I, double-blind, placebo-controlled clinical trial was performed in 60 healthy adults, 18 to 40 ye
Externí odkaz:
https://doaj.org/article/bb6df2d5e1e744729c3ccc75dafbda24
Autor:
Fernando Pastor, Mario M Soldevilla, Helena Villanueva, Despina Kolonias, Susana Inoges, Ascensión L de Cerio, Romy Kandzia, Victor Klimyuk, Yuri Gleba, Eli Gilboa, Maurizio Bendandi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
CD28 is one of the main costimulatory receptors responsible for the proper activation of T lymphocytes. We have isolated two aptamers that bind to the CD28 receptor. As a monomer, one of them interfered with the binding of CD28 to its ligand (B7), pr
Externí odkaz:
https://doaj.org/article/18fdae2b082c4fb4b2a9b0cfc7cdfbec
Autor:
Daniel Tusé, Maria Malm, Kirsi Tamminen, André Diessner, Frank Thieme, Franziska Jarczowski, Vesna Blazevic, Victor Klimyuk
Publikováno v:
Vaccine. 40(7)
Noroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide. A safe and effective vaccine that prevents NoV infection or minimizes NoV disease burden is needed, especially for children and the elderly who are particu
Publikováno v:
Cytology and Genetics. 51:87-102
The study of viruses lasts for more than a century since their discovery in 1892. In recent decades, viruses are also being actively exploited as a biotechnological tool. Plant-virus-driven transient expression of heterologous proteins is an actively
Autor:
Maurizio Bendandi, Ascensión López-Díaz de Cerio, Fernando Pastor, Susana Inogés, Mario Martínez Soldevilla, Helena Villanueva, Arianne González, Patricia Rubio, Franziska Jarczowski, Victor Klimyuk
Publikováno v:
Journal of Vaccines, Immunology and Immunopathology. 3
Autor:
Jantipa Jobsri, Christian H. Ottensmeier, Duc Bui-Minh, Victor Klimyuk, Warayut Chotprakaikiat, Freda K. Stevenson, Natalia Savelyeva, Yuri Gleba, Elena Harden, Federica Cavallo, Alex Allen
Publikováno v:
Oncoimmunology
Passive antibody therapy for cancer is an effective but costly treatment modality. Induction of therapeutically potent anticancer antibodies by active vaccination is an attractive alternative but has proven challenging in cancer due to tolerogenic pr
Autor:
Stefan Herz, Daniel Tuse, J.-E. Butler-Ransohoff, Alison A. McCormick, Susana Inogés, Victor Klimyuk, Maurizio Bendandi, Romy Kandzia, Sylvestre Marillonnet, J. Lenz, Guy Vancanneyt, A. Nickstadt, Frank Thieme, R. Fröde, Yuri Gleba, A. Lopez-Diaz de Cerio, Helena Villanueva, Elena Soria
Publikováno v:
Annals of Oncology. 21:2420-2427
BACKGROUND: Animal and clinical studies with plant-produced single-chain variable fragment lymphoma vaccines have demonstrated specific immunogenicity and safety. However, the expression levels of such fragments were highly variable and required comp
Autor:
Daniel Tuse, Yuri Gleba, Carlos Becerra, Shan Pandya, Dieter Krause, Robert H. Collins, Romy Kandzia, Nora Ku, Franziska Jarczowski, Julian K.-C. Ma, Maurizio Bendandi, John Edward Butler-Ransohoff, Nyla Langford, Frank Thieme, Fernando Pastor, Ascensión López-Díaz de Cerio, Susana Inoges Sancho, Victor Klimyuk
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2015 (2015)
BioMed Research International, Vol 2015 (2015)
We report the first evaluation of plant-made conjugate vaccines for targeted treatment of B-cell follicular lymphoma (FL) in a Phase I safety and immunogenicity clinical study. Each recombinant personalized immunogen consisted of a tumor-derived, pla
Autor:
Victor Klimyuk, Gerben van Eldik, Sylvestre Marillonnet, Anatoli Giritch, Yuri Gleba, Carola Engler, Johan Botterman
Publikováno v:
Proceedings of the National Academy of Sciences. 103:14701-14706
Plant viral vectors allow expression of heterologous proteins at high yields, but so far, they have been unable to express heterooligomeric proteins efficiently. We describe here a rapid and indefinitely scalable process for high-level expression of