Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Victor J. Lotti"'
Autor:
Stephen E. de Laszlo, Raymond S. Chang, Tsing-Bau Chen, Kristie A. Faust, William J. Greenlee, Salah D. Kivlighn, Victor J. Lotti, Stacey S. O'Malley, Terry W. Schorn, Peter K. Siegl, Jennifer Tran, Gloria J. Zingaro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1359-1364
Modification of the 6-N-alkyl-N-acyl groups of L-159,689, 6 6-(N-benzoyl-N-pentyl)-amino-2-propyl-3-[(2′-(tetrazol-5-yl)biphen-4-yl)methyl]quinazolin-4-(3H)one led to the identification of the 6-(N-benzoyl-N-(3-pyridylmethyl)) analog (L-162,537). L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0a634555cb07627e9316d3c58e22ecc
https://doi.org/10.1016/0960-894x(95)00224-h
https://doi.org/10.1016/0960-894x(95)00224-h
Autor:
Peter K. S. Siegl, Salah D. Kivlighn, Gloria J. Zingaro, Tsing-Bau Chen, Kristie A. Faust, Victor J. Lotti, William J. Greenlee, Arthur A. Patchett, Thomas F. Walsh, Kenneth J. Fitch, Raymond S.L. Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1151-1154
Directed synthesis and pharmacological evaluation in a recently described class of α-phenoxyphenylacetic acid bearing angiotensin II (AII) receptor antagonists has afforded further potent AT 1 -selective AII antagonists. Substitution in the central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac6208c532d72a61e408771fa3545d7
https://doi.org/10.1016/0960-894x(95)00185-v
https://doi.org/10.1016/0960-894x(95)00185-v
Autor:
Salah D. Kivlighn, Kenneth J. Fitch, W.J. Greenlee, T. F. Walsh, Peter K. S. Siegl, R. S. L. Chang, Kristie A. Faust, Arthur A. Patchett, Tsing-Bau Chen, Victor J. Lotti, Gloria J. Zingaro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:155-158
A series of nonpeptidic AT1 selective angiotensin II (AII) antagonists containing a phenoxyphenylacetic acid element as a biphenyl tetrazole replacement have been identified. This series yielded compound 20 which exhibited binding affinities of AT1 =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdc507efde0eace8587fa3c1b7d5d9e
https://doi.org/10.1016/0960-894x(94)00476-v
https://doi.org/10.1016/0960-894x(94)00476-v
Autor:
Ralph A. Rivero, Peter K. S. Siegl, K. L. Flanagan, Salah D. Kivlighn, Wallace T. Ashton, Gloria J. Zingaro, Tsing-Bau Chen, Victor J. Lotti, R. S. L. Chang, S. S. O'malley, W.J. Greenlee, Linda L. Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2787-2792
A series of subnanomolar (IC50 triazolinone-based AT1/AT2-balanced AII antagonists has been identified. The 70-240-fold gain in AT2 activity relative to prototype compounds was achieved by the introduction of a 5-acylamino group on the N2-aryl moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7833c612680e51d2bc1ae919ba3ffd73
https://doi.org/10.1016/s0960-894x(01)80595-3
https://doi.org/10.1016/s0960-894x(01)80595-3
Autor:
William J. Greenlee, Terry S. Schorn, Kristie A. Faust, Peter K. S. Siegl, Salah D. Kivlighn, Tsing-Bau Chen, Stephen E. de Laszlo, Gloria J. Zingaro, Victor J. Lotti, Tomasz W. Glinka, Raymond S.L. Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2337-2342
The quinazoline sulfonylcarbamate L-163,579 (9) is a potent, balanced antagonist of the binding of angiotensin II (Ang II) to human AT 1 and AT 2 receptors. This antagonist produces a long-lasting blockade of Ang II-induced pressor response in both r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96faf37f446e5b44223383aee9e35010
https://doi.org/10.1016/0960-894x(94)85036-4
https://doi.org/10.1016/0960-894x(94)85036-4
Autor:
Tsing-B. Chen, Kristie A. Faust, Elizabeth M. Naylor, Bradley V. Clineschmidt, Prasun K. Chakravarty, Victor J. Lotti, Robert J. Bendesky, Stacey A. O'Malley, Paul J. Kling, Raymond S.L. Chang, Arthur A. Patchett, William J. Greenlee
Publikováno v:
Drug Development Research. 32:161-171
MK-996 (N-((4′-((5,7-Dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl) (1,1′-biphenyl)-2-yl) sulfonylbenzamide) interacted in a competitive manner with rabbit aortic angiotensin II (All) receptors as determined by Scatchard analysis of speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68303a85da0e134d25fe0d985f25b245
https://doi.org/10.1002/ddr.430320306
https://doi.org/10.1002/ddr.430320306
Autor:
William J. Greenlee, Salah D. Kivlighn, Victor J. Lotti, Terry S. Schorn, Peter K. S. Siegl, Stephen E. de Laszlo, Raymond S.L. Chang, Gloria J. Zingaro, Tomasz W. Glinka, Tsing-Bau Chen, Kristie A. Faust
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:81-86
The structure activity relationships of a series of 2-alkyl-6-(acylamino)-3-[((2′-acylaminosulfonyl)biphenyl-4-yl)methyl]quinazolin-4-(3H)-ones were studied in order to identify balanced angiotensin II antagonists capable of potent binding to both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b08df6995c9ff8a242546b0a89ed6c
https://doi.org/10.1016/s0960-894x(01)81126-4
https://doi.org/10.1016/s0960-894x(01)81126-4
Autor:
Gloria J. Zingaro, Salah D. Kivlighn, Peter K.S. Siegel, Raymond S.L. Chang, Victor J. Lotti, Robert A. Strelitz, Arthur A. Patchett, William J. Greenlee, Terry W. Schorn, Prasun K. Chakravarty, Tsing-Bau Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:75-80
A new series of quinazolinone-based AT 1 selective antagonists, bearing acylsulfonamides (-SO 2 NHCOR) as the tetrazole bioisosteres, was evaluated. While AT 1 potencies remained similar to the tetrazole analogs, the AT 2 receptor affinities were sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e58f370e2b9c602ee4796a2fa006fe75
https://doi.org/10.1016/s0960-894x(01)81125-2
https://doi.org/10.1016/s0960-894x(01)81125-2
Autor:
William J. Greenlee, Peter K. S. Siegl, Victor J. Lotti, Kenneth J. Fitch, Salah D. Kivlighn, Malcolm MacCoss, Thomas F. Walsh, Arthur A. Patchett, Raymond S.L. Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:219-222
The synthesis of a new class of angiotensin II receptor antagonists bearing a substituted imidazo[1,2-b]pyridazine moiety, and the evaluation of these compounds as isosteric replacements for potent imidazo[4,5-b]pyridine based antagonists is presente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1484c608891db9d6d7685cd07d20d6fb
https://doi.org/10.1016/s0960-894x(01)81150-1
https://doi.org/10.1016/s0960-894x(01)81150-1
Autor:
L.W. Schaffer, Victor J. Lotti, Prasun K. Chakravarty, Wallace T. Ashton, Arthur A. Patchett, Tsing-Bau Chen, K. L. Flanagan, Salah D. Kivlighn, Elizabeth M. Naylor, W.J. Greenlee, Robert J. Bendesky, Linda L. Chang, Peter K. S. Siegl, R. S. L. Chang, Terry W. Schorn, Kristie A. Faust, Gloria J. Zingaro, Paul J. Kling
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:115-120
A series of trisubstituted triazolinones with a [2′-(N-acylsulfamoy)biphenyl-4-yl]methyl side chain at N4 has been prepared. The inhibition of AII pressor responses by these potent AT1-selective AII antagonists indicated some of them to be superior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::720a97dfb54ac5c0536c2b9ce2534228
https://doi.org/10.1016/s0960-894x(01)81132-x
https://doi.org/10.1016/s0960-894x(01)81132-x