Zobrazeno 1 - 10
of 1 190
pro vyhledávání: '"Victor J. Hruby"'
Autor:
Zhijun Wu, Victor J. Hruby
Publikováno v:
ACS Omega, Vol 4, Iss 17, Pp 17457-17476 (2019)
Externí odkaz:
https://doaj.org/article/595a48b9f2d4443dafa18d79f65a15d3
Publikováno v:
Journal of Medicinal Chemistry. 66:6715-6724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::319e5d2317c12c02e1b796716ea6facf
https://doi.org/10.1021/acs.jmedchem.2c01794
https://doi.org/10.1021/acs.jmedchem.2c01794
Autor:
Yang Zhou, Monica K. Chawla, Jose L. Rios-Monterrosa, Lingzhi Wang, Marc A. Zempare, Victor J. Hruby, Carol A. Barnes, Minying Cai
Publikováno v:
Molecules, Vol 26, Iss 20, p 6266 (2021)
Brain G-protein coupled receptors have been hypothesized to be potential targets for maintaining or restoring cognitive function in normal aged individuals or in patients with neurodegenerative disease. A number of recent reports suggest that activat
Externí odkaz:
https://doaj.org/article/e0712418a2494dacae45609da6fc65fe
Autor:
Zekun Liu, Victor J. Hruby
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:4125-4136
The MC4R, a GPCR, has long been a major target for obesity treatment. As the most well-studied melanocortin receptor subtype, the evolutionary knowledge pushes the drug development and structure-activity relationship (SAR) moving forward. The past de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f7936a1bfb8202e1762a45cdc86468
https://doi.org/10.1111/jcmm.17441
https://doi.org/10.1111/jcmm.17441
Autor:
Jarl E. S. Wikberg, Jeffrey B. Tatro, Helgi Schiöth, Colin Pouton, Kathleen G. Mountjoy, Victor J. Hruby, Carrie Haskell-Luevano, Ira Gantz, Tung M. Fong, Sadaf Farooqi, Alex N. Eberle, Roger D. Cone, Adrian J. L. Clark, Biao-Xin Chai, Vanni Caruso
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e1dd58e2809f3d3ee0d5953002ec11
https://doi.org/10.2218/gtopdb/f38/2023.1
https://doi.org/10.2218/gtopdb/f38/2023.1
Autor:
Robert J. Gillies, Victor J. Hruby, Eugene A. Mash, Haiyong Han, Brenda Baggett, David L. Morse, Ronald M. Lynch, Jatinder Josan, Josef Vagner, Liping Xu
A novel approach to specifically target tumor cells for detection and treatment is the proposed use of heteromultivalent ligands, which are designed to interact with, and noncovalently crosslink, multiple different cell surface receptors. Although en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f12fcb85ef528fa8bcaa799d7065c11
https://doi.org/10.1158/1535-7163.c.6531459
https://doi.org/10.1158/1535-7163.c.6531459
Autor:
Haiyong Han, Robert J. Gillies, Victor J. Hruby, Daniel D. Von Hoff, Michael J. Demeure, Maria Trissal, John Pearson, Sonsoles Shack, Phillip Stafford, Vijayalakshmi Shanmugam, Galen Hostetter, David L. Morse, Yoganand Balagurunathan
Supplementary Table S1 from Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555c2d091e2a8bfaec12ecc732c5bb6b
https://doi.org/10.1158/1535-7163.22484451
https://doi.org/10.1158/1535-7163.22484451
Autor:
Robert J. Gillies, Victor J. Hruby, Eugene A. Mash, Haiyong Han, Brenda Baggett, David L. Morse, Ronald M. Lynch, Jatinder Josan, Josef Vagner, Liping Xu
Supplementary Figures 1-6 from Enhanced targeting with heterobivalent ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1998e4e68b92bc782904b5e3e98f64ac
https://doi.org/10.1158/1535-7163.22484562.v1
https://doi.org/10.1158/1535-7163.22484562.v1
Autor:
Haiyong Han, Robert J. Gillies, Victor J. Hruby, Daniel D. Von Hoff, Michael J. Demeure, Maria Trissal, John Pearson, Sonsoles Shack, Phillip Stafford, Vijayalakshmi Shanmugam, Galen Hostetter, David L. Morse, Yoganand Balagurunathan
Multimeric ligands are ligands that contain multiple binding domains that simultaneously target multiple cell-surface proteins. Due to cooperative binding, multimeric ligands can have high avidity for cells (tumor) expressing all targeting proteins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3694aed169eeb5bd63bccda74d8634c9
https://doi.org/10.1158/1535-7163.c.6531408
https://doi.org/10.1158/1535-7163.c.6531408
Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Autor:
Yeon Sun Lee, Michael Remesic, Cyf Ramos-Colon, Zhijun Wu, Justin LaVigne, Gabriella Molnar, Dagmara Tymecka, Aleksandra Misicka, John M. Streicher, Victor J. Hruby, Frank Porreca
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 625 (2021)
In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the fi
Externí odkaz:
https://doaj.org/article/5b6b2c3eba6f414bbf633d9023f2ac2b