Výsledky vyhledávání - "Victor J Weigman"

Abstract 5933: Trimodal molecular analysis in single cells of a primary breast cancer cohort with ResolveOME ™ amplification

Autor: Jon S. Zawistowski, Isai Salas-Gonzalez, Tia A. Tate, Tatiana V. Morozova, Katherine Kennedy, Durga M. Arvapalli, Swetha D. Velivela, Jamie E. Remington, Josh Croteau, Kevin Taylor, Jeff G. Blackinton, Victor J. Weigman, Jeffrey R. Marks, Eun-Sil Shelley Hwang, Gary L. Harton, Jay A. West

Publikováno v: Cancer Research. 83:5933-5933

The ResolveOME™ single-cell amplification solution unites whole-genome and full-length transcriptome information from the same cell, providing critical insight between these layers not possible when analyzed in isolation. We expand here upon the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acb7d91a61bb75597bd216b55b3a9149
https://doi.org/10.1158/1538-7445.am2023-5933

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High-Throughput Detection of Clinically Relevant Mutations in Archived Tumor Samples by Multiplexed PCR and Next-Generation Sequencing

Autor: Richard Bourgon, Yinghui Guan, Garret Hampton, Shan Lu, Yibing Yan, David Wang, Hartmut Koeppen, Weiru Wang, Yulei Wang, Mark R. Lackner, Lisa Ryner, Lukas C. Amler, Victor J. Weigman, Rajesh Patel

Publikováno v: Clinical Cancer Research. 20:2080-2091

Purpose: Tailoring cancer treatment to tumor molecular characteristics promises to make personalized medicine a reality. However, reliable genetic profiling of archived clinical specimens has been hindered by limited sensitivity and high false-positi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db36309f2dfb6cebb97bfcbac22cf7ee
https://doi.org/10.1158/1078-0432.ccr-13-3114

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Abstract 1346: Panel-based tumor mutational burden (TMB) analysis of matched tumor and plasma specimens using Illumina’s TruSight Oncology 500 next-generation sequencing assay

Autor: Victor J. Weigman, Rajiv Raja, Tingting Jiang, Stephanie B. Hastings, Philip Brohawn, Gunjan Hariani, Chen Zhao, Patrick Hurban, Traci Pawlowski

Publikováno v: Cancer Research. 79:1346-1346

Checkpoint inhibitor (CPI) therapy demonstrates a remarkable clinical benefit in many cancer types. However, the ability to successfully select patients who will benefit from CPIs is still limited. Tumor mutational burden (TMB), a measure of the numb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abc9d2fdfb4ca264a405a1a37196c444
https://doi.org/10.1158/1538-7445.am2019-1346

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TMB standardization by alignment to reference standards: Phase II of the Friends of Cancer Research TMB Harmonization Project

Autor: Shu-Jen Chen, Victor J Weigman, Chen Zhao, Arnaud Papin, Matthew James Butler, Laura E. MacConaill, Vincent Funari, David Fabrizio, Ahmet Zehir, Aparna Pallavajjala, Diana M. Merino, Jeffrey M. Conroy, Ruchi Chaudhary, Paul M. Williams, Wangjuh Sting Chen, Matthew D. Hellmann, Mark Sausen, Lisa M. McShane, Mingchao Xie

Publikováno v: Journal of Clinical Oncology. 37:2624-2624

2624 Background: Tumor mutational burden (TMB) is a predictive biomarker of response to immune checkpoint inhibitors across multiple cancers. In Phase 1 of the Friends of Cancer Research Harmonization Project, we demonstrated a robust correlation bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b01401987d9b8a399966e1b72bdb15fc
https://doi.org/10.1200/jco.2019.37.15_suppl.2624

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Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival

Autor: Joel S. Parker, Hann Hsiang Chao, Silje H. Nordgard, Charles M. Perou, Andrey A. Shabalin, Chika Nwachukwu, Tatyana A. Grushko, Vessela N. Kristensen, Anne Lise Børresen-Dale, Dezheng Huo, Victor J. Weigman, Xiaping He, Andrew B. Nobel, Olufunmilayo I. Olopade

Publikováno v: Breast Cancer Research and Treatment

Breast cancer is a heterogeneous disease with known expression-defined tumor subtypes. DNA copy number studies have suggested that tumors within gene expression subtypes share similar DNA Copy number aberrations (CNA) and that CNA can be used to furt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d67c07a6db8f6847cdadbf054fc696c
https://doi.org/10.1007/s10549-011-1846-y

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Allele-specific copy number analysis of tumors

Autor: Silje H. Nordgard, Peter Van Loo, Anders Zetterberg, Anne Lise Børresen-Dale, Inga H. Rye, Wei Sun, Vessela N. Kristensen, Victor J. Weigman, Charles M. Perou, Ole Christian Lingjærde, Hege G. Russnes, Bjørn Naume, Peter Marynen

Publikováno v: Proceedings of the National Academy of Sciences. 107:16910-16915

We present an allele-specific copy number analysis of the in vivo breast cancer genome. We describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis of tumors), to accurately dissect the allele-specific copy number of sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310dafebeb0524e49aed8f8ec1201569
https://doi.org/10.1073/pnas.1009843107

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Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status

Autor: Robert A. Jones, Jason I. Herschkowitz, Huiqin Li, Charles M. Perou, Eldad Zacksenhaus, Victor J. Weigman, Tao Deng, Ming-Sound Tsao, Timothy F. Lane, Jeff C. Liu, Zhe Jiang

Publikováno v: Journal of Clinical Investigation. 120:3296-3309

Breast cancer is a highly heterogeneous disease, with several different subtypes being characterized by distinct histology, gene expression patterns, and genetic alterations. The tumor suppressor gene retinoblastoma 1 (RB1) is frequently lost in both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbd07d3b3d8266a856af68755255f56
https://doi.org/10.1172/jci41490

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