Zobrazeno 1 - 10
of 627
pro vyhledávání: '"Victor J Dzau"'
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223842 (2019)
The process by which fibroblasts are directly reprogrammed into cardiomyocytes involves two stages; initiation and maturation. Initiation represents the initial expression of factors that induce fibroblasts to transdifferentiate into cardiomyocytes.
Externí odkaz:
https://doaj.org/article/c337ac6290004975895bc0b8860756ca
Autor:
Lawrence O Gostin, Oyewale Tomori, Suwit Wibulpolprasert, Ashish K Jha, Julio Frenk, Suerie Moon, Joy Phumaphi, Peter Piot, Barbara Stocking, Victor J Dzau, Gabriel M Leung
Publikováno v:
PLoS Medicine, Vol 13, Iss 5, p e1002042 (2016)
Lawrence Gostin and colleagues offer a set of priorities for global health preparedness and response for future infectious disease threats.
Externí odkaz:
https://doaj.org/article/d9e3d539c031479986c6b41533800a45
Autor:
Sonalí Harris, Iqra Anwar, Syeda S. Baksh, Richard E. Pratt, Victor J. Dzau, Conrad P. Hodgkinson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract In a previous report, we demonstrated that Cbx1, PurB and Sp3 inhibited cardiac muscle differentiation by increasing nucleosome density around cardiac muscle gene promoters. Since cardiac and skeletal muscle express many of the same proteins
Externí odkaz:
https://doaj.org/article/090c31b4b9ad4fe3b9b2138540c91f34
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102160- (2024)
Reprogramming scar fibroblasts into cardiomyocytes has been proposed to reverse the damage associated with myocardial infarction. However, the limited improvement in cardiac function calls for enhanced strategies. We reported enhanced efficacy of our
Externí odkaz:
https://doaj.org/article/9c4cf1afc2cb4325b8d0a12e4c079fb9
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C843-C855
We discovered that innate immunity plays an important role in the reprogramming of fibroblasts into cardiomyocytes. In this report, we define the role of a novel retinoic acid-inducible gene 1 Yin Yang 1 (Rig1:YY1) pathway. We found that fibroblast t
Autor:
Victor J. Dzau
Publikováno v:
American Journal of Physical Medicine & Rehabilitation. 102:475-480
Autor:
Kushal T, Kadakia, Celynne A, Balatbat, Albert L, Siu, I Glenn, Cohen, Consuelo H, Wilkins, Victor J, Dzau, Anaeze C, Offodile 2nd
Publikováno v:
The Milbank Quarterly. 100:673-701
Policy Points Hospital-at-Home (HaH) is a home-based alternative for acute care that has expanded significantly under COVID-19 regulatory flexibilities. The post-pandemic policy agenda for HaH will require consideration of multistakeholder perspectiv
Publikováno v:
Scientific Reports. 13
Current methods to generate cardiomyocytes from induced pluripotent stem cells (iPSc) utilize broad-spectrum pharmacological inhibitors. These methods give rise to cardiomyocytes which are typically immature. Since we have recently demonstrated that
Publikováno v:
Academic Medicine. 97:479-483
The COVID-19 pandemic created significant challenges for academic health systems (AHSs) across their tripartite mission of providing clinical care, conducting research, and educating learners. Despite these challenges, AHSs played an invaluable role
Autor:
Philippe Menasché, Wolfram-Hubertus Zimmermann, Eduardo Marbán, Roberto Bolli, Daniel J. Garry, Timothy J. Kamp, Victor J. Dzau, Jianyi Zhang, Joseph C. Wu
Publikováno v:
Journal of the American College of Cardiology. 78:2092-2105
This paper aims to provide an important update on the recent preclinical and clinical trials using cell therapy strategies and engineered heart tissues for the treatment of postinfarction left ventricular remodeling and heart failure. In addition to