Zobrazeno 1 - 10
of 627
pro vyhledávání: '"Victor J, Dzau"'
Autor:
Sonalí Harris, Iqra Anwar, Syeda S. Baksh, Richard E. Pratt, Victor J. Dzau, Conrad P. Hodgkinson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract In a previous report, we demonstrated that Cbx1, PurB and Sp3 inhibited cardiac muscle differentiation by increasing nucleosome density around cardiac muscle gene promoters. Since cardiac and skeletal muscle express many of the same proteins
Externí odkaz:
https://doaj.org/article/090c31b4b9ad4fe3b9b2138540c91f34
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102160- (2024)
Reprogramming scar fibroblasts into cardiomyocytes has been proposed to reverse the damage associated with myocardial infarction. However, the limited improvement in cardiac function calls for enhanced strategies. We reported enhanced efficacy of our
Externí odkaz:
https://doaj.org/article/9c4cf1afc2cb4325b8d0a12e4c079fb9
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Current methods to generate cardiomyocytes from induced pluripotent stem cells (iPSc) utilize broad-spectrum pharmacological inhibitors. These methods give rise to cardiomyocytes which are typically immature. Since we have recently demonstra
Externí odkaz:
https://doaj.org/article/fed1b86478eb4f6da5f460e534ce8dfe
Autor:
Mohamed Abou-el-Enein, Aris Angelis, Frederick R. Appelbaum, Nancy C. Andrews, Susan E. Bates, Arlene S. Bierman, Malcolm K. Brenner, Marina Cavazzana, Michael A. Caligiuri, Hans Clevers, Emer Cooke, George Q. Daley, Victor J. Dzau, Lee M. Ellis, Harvey V. Fineberg, Lawrence S.B. Goldstein, Stephen Gottschalk, Margaret A. Hamburg, Donald E. Ingber, Donald B. Kohn, Adrian R. Krainer, Marcela V. Maus, Peter Marks, Christine L. Mummery, Roderic I. Pettigrew, Joni L. Rutter, Sarah A. Teichmann, Andre Terzic, Fyodor D. Urnov, David A. Williams, Jedd D. Wolchok, Mark Lawler, Cameron J. Turtle, Gerhard Bauer, John P.A. Ioannidis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 11-14 (2021)
Externí odkaz:
https://doaj.org/article/c3fa45c6e32349f68ffd7fcab701dc16
Autor:
Jiabiao Hu, Conrad P. Hodgkinson, Richard E. Pratt, JaeWoo Lee, Bruce A. Sullenger, Victor J. Dzau
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 55-62 (2021)
Reprogramming scar fibroblasts into new heart muscle cells has the potential to restore function to the injured heart. However, the effectiveness of reprogramming is notably low. We have recently demonstrated that the effectiveness of reprogramming f
Externí odkaz:
https://doaj.org/article/a6c63bacc4084937af5bd7c64aa9f79e
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C843-C855
We discovered that innate immunity plays an important role in the reprogramming of fibroblasts into cardiomyocytes. In this report, we define the role of a novel retinoic acid-inducible gene 1 Yin Yang 1 (Rig1:YY1) pathway. We found that fibroblast t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf689386c8e0a986b6c9451234b894e6
https://doi.org/10.1152/ajpcell.00402.2022
https://doi.org/10.1152/ajpcell.00402.2022
Autor:
Victor J. Dzau
Publikováno v:
American Journal of Physical Medicine & Rehabilitation. 102:475-480
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::101c272282829a4f284dd6c26b520954
https://doi.org/10.1097/phm.0000000000002234
https://doi.org/10.1097/phm.0000000000002234
Autor:
Kushal T, Kadakia, Celynne A, Balatbat, Albert L, Siu, I Glenn, Cohen, Consuelo H, Wilkins, Victor J, Dzau, Anaeze C, Offodile 2nd
Publikováno v:
The Milbank Quarterly. 100:673-701
Policy Points Hospital-at-Home (HaH) is a home-based alternative for acute care that has expanded significantly under COVID-19 regulatory flexibilities. The post-pandemic policy agenda for HaH will require consideration of multistakeholder perspectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24721020c05a9824b870d55eb4a8cc44
https://doi.org/10.1111/1468-0009.12586
https://doi.org/10.1111/1468-0009.12586
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223842 (2019)
The process by which fibroblasts are directly reprogrammed into cardiomyocytes involves two stages; initiation and maturation. Initiation represents the initial expression of factors that induce fibroblasts to transdifferentiate into cardiomyocytes.
Externí odkaz:
https://doaj.org/article/c337ac6290004975895bc0b8860756ca
Publikováno v:
Academic Medicine. 97:479-483
The COVID-19 pandemic created significant challenges for academic health systems (AHSs) across their tripartite mission of providing clinical care, conducting research, and educating learners. Despite these challenges, AHSs played an invaluable role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fe46a8ef7471277be1ad57aafd7242
https://doi.org/10.1097/acm.0000000000004572
https://doi.org/10.1097/acm.0000000000004572