Výsledky vyhledávání - "Victor H Engelhard"

Akademický článek

Tertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas

Autor: Nicole L. Edmonds, Sarah E Gradecki, Priya Katyal, Kevin T Lynch, Anne M Stowman, Alejandro A Gru, Victor H Engelhard, Craig L Slingluff, Ileana S. Mauldin

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTTertiary lymphoid structures (TLS) are ectopic lymphoid structures that can arise in human cancers and are associated with improved overall survival (OS) and response to immune checkpoint blockade (ICB) in several cancers, including non-desmo

Externí odkaz: https://doaj.org/article/76a7c46882b34e41922abb9223121455

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Akademický článek

Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma

Autor: Ileana S Mauldin, Nolan A Wages, Max O Meneveau, Kevin T Lynch, Samuel J Young, Craig L Slingluff Jr, Victor H Engelhard

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)

Background Tertiary lymphoid structures (TLSs) are immune aggregates in peripheral tissues that may support adaptive immune responses. Their presence has been associated with clinical response to checkpoint blockade therapy (CBT), but it is unknown w

Externí odkaz: https://doaj.org/article/bc704d967f104405830c38beb6d775f1

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Akademický článek

MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background Phosphorylated peptides presented by MHC molecules represent a new class of neoantigens expressed on cancer cells and recognized by CD8 T-cells. These peptides are promising targets for cancer immunotherapy. Previous work identified an HLA

Externí odkaz: https://doaj.org/article/2f1ba13970c949eeb55d8d1382a456e4

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Akademický článek

Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment.

Autor: Jarish N Cohen, Eric F Tewalt, Sherin J Rouhani, Erica L Buonomo, Amber N Bruce, Xiaojiang Xu, Stefan Bekiranov, Yang-Xin Fu, Victor H Engelhard

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87740 (2014)

Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase

Externí odkaz: https://doaj.org/article/38c5d3067d0744d68f5204b2af509b13

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Akademický článek

Tumor necrosis factor receptor regulation of peripheral node addressin biosynthetic components in tumor endothelial cells

Autor: Anthony B. Rodriguez, Geoffrey Parriott, Victor H. Engelhard

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Tumor-associated tertiary lymphoid structures are ectopic lymphoid aggregates that have considerable morphological, cellular, and molecular similarity to secondary lymphoid organs, particularly lymph nodes. Tumor vessels expressing peripheral node ad

Externí odkaz: https://doaj.org/article/6a65bdb4b3ab446ca08a33a0ce67ef8b

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