Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Victor H Carpio"'
Autor:
Jang-June Park, Emily P. Thi, Victor H. Carpio, Yingzhi Bi, Andrew G. Cole, Bruce D. Dorsey, Kristi Fan, Troy Harasym, Christina L. Iott, Salam Kadhim, Jin Hyang Kim, Amy C. H. Lee, Duyan Nguyen, Bhavna S. Paratala, Ruiqing Qiu, Andre White, Damodharan Lakshminarasimhan, Christopher Leo, Robert K. Suto, Rene Rijnbrand, Sunny Tang, Michael J. Sofia, Chris B. Moore
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Programmed death-ligand 1 (PD-L1) is involved in the inhibition of antigen specific T cells via ligation of programmed death 1 (PD-1). Here, the authors show checkpoint inhibition by use of small molecule inhibition of PD-L1 which in a humanised mous
Externí odkaz:
https://doaj.org/article/cbf4ada82c004c6dad7c4c374ea066bb
Autor:
Victor H. Carpio, Florentin Aussenac, Lucinda Puebla-Clark, Kyle D. Wilson, Alejandro V. Villarino, Alexander L. Dent, Robin Stephens
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101310- (2020)
Summary: Hybrid Th1/Tfh cells (IFN-γ+IL-21+CXCR5+) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ+ T cells control parasitemia, whereas antibody and IL-21+Bcl6+ T cells effect final clearance, sugg
Externí odkaz:
https://doaj.org/article/b487e74dccc04a409f18f5c68412ec2a
Autor:
Mingming Sun, Wei Wu, Liang Chen, Wenjing Yang, Xiangsheng Huang, Caiyun Ma, Feidi Chen, Yi Xiao, Ye Zhao, Chunyan Ma, Suxia Yao, Victor H. Carpio, Sara M. Dann, Qihong Zhao, Zhanju Liu, Yingzi Cong
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
T cells play a critical role in intestinal homeostasis, with increasing evidence suggesting a role for the microbiome metabolome in modulating this response. Here the authors show short-chain fatty acids promote IL-10 production in Th1 cells.
Externí odkaz:
https://doaj.org/article/0ba5e8cba7f0472bb973f7f9800301ee
Autor:
Kyle D. Wilson, Lorenzo F. Ochoa, Olivia D. Solomon, Rahul Pal, Sandra M. Cardona, Victor H. Carpio, Philip H. Keiser, Astrid E. Cardona, Gracie Vargas, Robin Stephens
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-17 (2018)
Abstract Background Cerebral malaria (CM) is the most lethal outcome of Plasmodium infection. There are clear correlations between expression of inflammatory cytokines, severe coagulopathies, and mortality in human CM. However, the mechanisms intertw
Externí odkaz:
https://doaj.org/article/f432188e6898481987ebc8c893564802
Autor:
Samad A. Ibitokou, Komi Gbedande, Michael M. Opata, Victor H. Carpio, Karis M. Marshall, Robin Stephens
Publikováno v:
Infection and Immunity. 91
CD4 T cells are required, along with antibodies, for complete protection from blood-stage infection withPlasmodium spp., which cause malaria. Without continuous exposure, as on emigration of people from endemic areas, protection from malaria decays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cc553659cecbfa8140441fe2029cd2
https://doi.org/10.1128/iai.00531-22
https://doi.org/10.1128/iai.00531-22
Autor:
Michael M Opata, Samad A Ibitokou, Victor H Carpio, Karis M Marshall, Brian E Dillon, Jordan C Carl, Kyle D Wilson, Christine M Arcari, Robin Stephens
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006960 (2018)
Protection at the peak of Plasmodium chabaudi blood-stage malaria infection is provided by CD4 T cells. We have shown that an increase in Th1 cells also correlates with protection during the persistent phase of malaria; however, it is unclear how the
Externí odkaz:
https://doaj.org/article/3fa6c561c472495e9d5e2e425b67750c
Autor:
Victor H Carpio, Michael M Opata, Marelle E Montañez, Pinaki P Banerjee, Alexander L Dent, Robin Stephens
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174048 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0144654.].
Externí odkaz:
https://doaj.org/article/5332a28abbb34de8ba912bb8d92eef4d
Autor:
Victor H Carpio, Michael M Opata, Marelle E Montañez, Pinaki P Banerjee, Alexander L Dent, Robin Stephens
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0155570 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0144654.].
Externí odkaz:
https://doaj.org/article/d819d62cd20b4e93aedbbfc24aec325c
Publikováno v:
Immunol Rev
Plasmodium falciparum infection and malaria remain a risk for millions of children and pregnant women. Here, we seek to integrate knowledge of mouse and human T helper cell (Th) responses to blood-stage Plasmodium infection to understand their contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93c058b8df3fad4aaafe845555125b2
https://doi.org/10.1111/imr.12835
https://doi.org/10.1111/imr.12835
Autor:
Victor H Carpio, Michael M Opata, Marelle E Montañez, Pinaki P Banerjee, Alexander L Dent, Robin Stephens
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144654 (2015)
CD4 T cells are required to fight malaria infection by promoting both phagocytic activity and B cell responses for parasite clearance. In Plasmodium chabaudi infection, one specific CD4 T cell subset generates anti-parasitic IFN-γ and the antibody-p
Externí odkaz:
https://doaj.org/article/deba7afa4e5d409a8f6072c1fbd7b4a7