A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Autor: Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Emilie Crouchet, Zeina Nehme, Fabio Del Zompo, Frank Jühling, Marine A. Oudot, Sarah C. Durand, François H. T. Duong, Sara Cherradi, Victor Gonzalez Motos, Nuno Almeida, Clara Ponsolles, Laura Heydmann, Tessa Ostyn, Antonin Lallement, Patrick Pessaux, Emanuele Felli, Andrea Cavalli, Jacopo Sgrignani, Christine Thumann, Olga Koutsopoulos, Bryan C. Fuchs, Yujin Hoshida, Maike Hofmann, Mogens Vyberg, Birgitte Martine Viuff, Elisabeth D. Galsgaard, Greg Elson, Alberto Toso, Markus Meyer, Roberto Iacone, Tamas Schweighoffer, Geoffrey Teixeira, Solange Moll, Claudio De Vito, Tania Roskams, Irwin Davidson, Danijela Heide, Mathias Heikenwälder, Mirjam B. Zeisel, Joachim Lupberger, Laurent Mailly, Catherine Schuster, Thomas F. Baumert

Publikováno v: Roehlen, N, Saviano, A, El Saghire, H, Crouchet, E, Nehme, Z, Del Zompo, F, Jühling, F, Oudot, M A, Durand, S C, Duong, F H T, Cherradi, S, Gonzalez Motos, V, Almeida, N, Ponsolles, C, Heydmann, L, Ostyn, T, Lallement, A, Pessaux, P, Felli, E, Cavalli, A, Sgrignani, J, Thumann, C, Koutsopoulos, O, Fuchs, B C, Hoshida, Y, Hofmann, M, Vyberg, M, Viuff, B M, Galsgaard, E D, Elson, G, Toso, A, Meyer, M, Iacone, R, Schweighoffer, T, Teixeira, G, Moll, S, De Vito, C, Roskams, T, Davidson, I, Heide, D, Heikenwälder, M, Zeisel, M B, Lupberger, J, Mailly, L, Schuster, C & Baumert, T F 2022, ' A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity ', Science Translational Medicine, vol. 14, no. 676, eabj4221, pp. eabj4221 . https://doi.org/10.1126/scitranslmed.abj4221

Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the tight junct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15761706f515b3e02c2102683616d7
https://vbn.aau.dk/da/publications/ae147006-4f6f-4e57-bf99-f23fc8da0fa9

Profibrotic Signaling and HCC Risk during Chronic Viral Hepatitis: Biomarker Development

Autor: Joachim Lupberger, Thomas Baumert, Alessia Virzì, Simona Tripon, Victor Gonzalez-Motos

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, 2021, 10 (5), ⟨10.3390/jcm10050977⟩
Journal of Clinical Medicine, Vol 10, Iss 977, p 977 (2021)

Despite breakthroughs in antiviral therapies, chronic viral hepatitis B and C are still the major causes of liver fibrosis and hepatocellular carcinoma (HCC). Importantly, even in patients with controlled infection or viral cure, the cancer risk cann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7431ccac8240c10bb16e0cd9539e208a
http://europepmc.org/articles/PMC7957739

Single cell RNA-seq of patient liver tissues uncover HRH2+/CLEC5a high/macro low macrophages as therapeutic target for the treatment of liver fibrosis and cancer prevention

Autor: Emilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire, Xiaochen Sun, Hadassa Hirschfield, Natascha Roehlen, Frank Jühling, Antonio Saviano, Victor Gonzalez-Motos, Anu Venkatesh, Clara Ponsolles, Joachim Lupberger, François H.T. Duong, Shijia Zhu, Mozhdeh Sojoodi, Ricard Masia, Lan Wei, Marine Oudot, Sarah Durand, Shigeki Nakagawa, Atsushi Ono, Won-Min Song, Takaaki Higashi, Rosa S. Kim, C Billie Bian, Tom Croonenborghs, Raymond Chung, Danijela Heide, Jenny Hetzer, Beate Straub, Detlef Schuppan, Anna P. Koh, Milind Mahajan, Mathias Heikenwalder, Emanuele Felli, Patrick Pessaux, Kenneth K. Tanabe, Catherine Schuster, Nathalie Pochet, Mirjam Zeisel, Bryan C. Fuchs, Yujin Hoshida, Thomas Baumert

Publikováno v: Journal of Hepatology. 73:S97

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fe6dc815b49afee00016bf9be9d02ca
https://doi.org/10.1016/s0168-8278(20)30724-8

Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration.

Autor: Víctor González-Motos, Carina Jürgens, Birgit Ritter, Kai A Kropp, Verónica Durán, Olav Larsen, Anne Binz, Werner J D Ouwendijk, Tihana Lenac Rovis, Stipan Jonjic, Georges M G M Verjans, Beate Sodeik, Thomas Krey, Rudolf Bauerfeind, Thomas F Schulz, Benedikt B Kaufer, Ulrich Kalinke, Amanda E I Proudfoot, Mette M Rosenkilde, Abel Viejo-Borbolla

Publikováno v: PLoS Pathogens, Vol 13, Iss 5, p e1006346 (2017)

Varicella zoster virus (VZV) is a highly prevalent human pathogen that establishes latency in neurons of the peripheral nervous system. Primary infection causes varicella whereas reactivation results in zoster, which is often followed by chronic pain

Externí odkaz: https://doaj.org/article/67a7306e93734a6fb0c1a6b9d1cccf9f