Mouse vascularized adipose spheroids: an organotypic model for thermogenic adipocytes

Autor: Laura Ingeborg Davidsen, Carolina E. Hagberg, Victor Goitea, Stine Meinild Lundby, Steen Larsen, Morten Frendø Ebbesen, Natasha Stanic, Hande Topel, Jan-Wilhelm Kornfeld

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Adipose tissues, particularly beige and brown adipose tissue, play crucial roles in energy metabolism. Brown adipose tissues’ thermogenic capacity and the appearance of beige cells within white adipose tissue have spurred interest in their metaboli

Externí odkaz: https://doaj.org/article/06226211492f46eeb6a14f769791f6c1

Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment

Autor: Klaire Yixin Fjæstad, Anne Mette Askehøj Rømer, Victor Goitea, Astrid Zedlitz Johansen, Marie-Louise Thorseth, Marco Carretta, Lars Henning Engelholm, Lars Grøntved, Niels Junker, Daniel Hargbøl Madsen

Publikováno v: Fjæstad, K Y, Rømer, A M A, Goitea, V, Johansen, A Z, Thorseth, M L, Carretta, M, Engelholm, L H, Grøntved, L, Junker, N & Madsen, D H 2022, ' Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment ', Oncogene, vol. 41, pp. 1364-1375 . https://doi.org/10.1038/s41388-021-02170-0
Fjæstad, K Y, Rømer, A M A, Goitea, V, Johansen, A Z, Thorseth, M L, Carretta, M, Engelholm, L H, Grøntved, L, Junker, N & Madsen, D H 2022, ' Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment ', Oncogene, vol. 41, no. 9, pp. 1364-1375 . https://doi.org/10.1038/s41388-021-02170-0

The development of immune checkpoint inhibitors (ICI) marks an important breakthrough of cancer therapies in the past years. However, only a limited fraction of patients benefit from such treatments, prompting the search for immune modulating agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132a542c4788a27e2d7a5a87b406a60d
https://curis.ku.dk/ws/files/314704412/s41388_021_02170_0.pdf

Progesterone Receptor Modulates Extraembryonic Mesoderm and Cardiac Progenitor Specification during Mouse Gastrulation

Autor: Anna Maria Drozd, Luca Mariani, Xiaogang Guo, Victor Goitea, Niels Alvaro Menezes, Elisabetta Ferretti

Publikováno v: Drozd, A M, Mariani, L, Guo, X, Goitea, V, Menezes, N A & Ferretti, E 2022, ' Progesterone Receptor Modulates Extraembryonic Mesoderm and Cardiac Progenitor Specification during Mouse Gastrulation ', International Journal of Molecular Sciences, vol. 23, no. 18, 10307 . https://doi.org/10.3390/ijms231810307
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10307

Progesterone treatment is commonly employed to promote and support pregnancy. While maternal tissues are the main progesterone targets in humans and mice, its receptor (PGR) is expressed in the murine embryo, questioning its function during embryonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600103dd4a0ced47970550ad4af16d6e
https://doi.org/10.3390/ijms231810307

Arginylated Calreticulin Increases Apoptotic Response Induced by Bortezomib in Glioma Cells

Autor: Victor Goitea, Laura V. Bonnet, Mauricio R. Galiano, Andrea Comba, Marta E. Hallak

Publikováno v: Molecular Neurobiology. 56:1653-1664

After retrotranslocation from the endoplasmic reticulum to the cytoplasm, calreticulin is modified by the enzyme arginyltransferase-1 (ATE1). Cellular levels of arginylated calreticulin (R-CRT) are regulated in part by the proteasomal system. Under v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd24ebd142c19c6a9741b79e66c85c8e
https://doi.org/10.1007/s12035-018-1182-x

Post-translational protein arginylation in the normal nervous system and in neurodegeneration

Autor: Mauricio R. Galiano, Marta E. Hallak, Victor Goitea

Publikováno v: Journal of Neurochemistry. 138:506-517

Post-translational arginylation of proteins is an important regulator of many physiological pathways in cells. This modification was originally noted in protein degradation during neurodegenerative processes, with an apparently different physiologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fc5bd9d81ddb202b0062cf4eafd27b
https://doi.org/10.1111/jnc.13708