Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Victor G. Howard"'
Autor:
Brandon B. Boland, Rhianna C. Laker, Siobhan O'Brien, Sadichha Sitaula, Isabelle Sermadiras, Jens Christian Nielsen, Pernille Barkholt, Urmas Roostalu, Jacob Hecksher-Sørensen, Sara Rubek Sejthen, Ditte Dencker Thorbek, Arthur Suckow, Nicole Burmeister, Stephanie Oldham, Sarah Will, Victor G. Howard, Benji M. Gill, Philip Newton, Jacqueline Naylor, David C. Hornigold, Jotham Austin, Louise Lantier, Owen P. McGuinness, James L. Trevaskis, Joseph S. Grimsby, Christopher J. Rhodes
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101392- (2022)
Objective: Obesity-linked type 2 diabetes (T2D) is a worldwide health concern and many novel approaches are being considered for its treatment and subsequent prevention of serious comorbidities. Co-administration of glucagon like peptide 1 (GLP-1) an
Externí odkaz:
https://doaj.org/article/b325ef86371a42baa07ae1549ba9e3b0
Autor:
Puneet Tyagi, Mika Koskinen, Jari Mikkola, Sanjay Sarkhel, Lasse Leino, Asha Seth, Shimona Madalli, Sarah Will, Victor G. Howard, Helen Brant, Dominic Corkill
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 553 (2022)
Diabetes mellitus is a major healthcare challenge. Pramlintide, a peptide analogue of the hormone amylin, is currently used as an adjunct with insulin for patients who fail to achieve glycemic control with only insulin therapy. However, hypoglycemia
Externí odkaz:
https://doaj.org/article/9dbbbd1699a845b2af03ce1c4a88f06d
Autor:
Charles Shyng, Umut Chagin, Cayse Coachys, Stephen Ioele, Ali Nowrouzi, Alex Rohacek, Sarah Elliott, Hayley Hanby, Scott Ashley, Lindsey C. Peed, Victor G. Howard, Mary Ault, Karen Huang, Gabrielle Jones, Heena Beck, Ronghua Meng, Sayali Saykhedkar, Andria Culbert, Dale Stevens, Kathila Alatsis, Daniel M. Cohen, Marco Crosariol, Sean Armour, Federico Mingozzi, Chris Riling
Publikováno v:
Molecular Genetics and Metabolism. 138:107319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06814a98d3e81bdc2926e2d700d89ab
https://doi.org/10.1016/j.ymgme.2022.107319
https://doi.org/10.1016/j.ymgme.2022.107319
Autor:
Puneet Tyagi, Mika Koskinen, Jari Mikkola, Sanjay Sarkhel, Lasse Leino, Asha Seth, Shimona Madalli, Sarah Will, Victor G. Howard, Helen Brant, Dominic Corkill
Publikováno v:
Pharmaceutics; Volume 14; Issue 3; Pages: 553
Diabetes mellitus is a major healthcare challenge. Pramlintide, a peptide analogue of the hormone amylin, is currently used as an adjunct with insulin for patients who fail to achieve glycemic control with only insulin therapy. However, hypoglycemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0e5dabb145c4c61ca7bb5b60a89750
https://pubmed.ncbi.nlm.nih.gov/35335929
https://pubmed.ncbi.nlm.nih.gov/35335929
Autor:
Qianxing Mo, Yong Gao, Makoto Fukuda, Jacqueline Naylor, Kenji Saito, Hsiaoyun Lin, Ting Yao, Kentaro Kaneko, Pingwen Xu, Elizabeth L. Cordonier, Miao Hsueh Chen, Yong Xu, Peter Ravn, Kevin W. Williams, Victor G. Howard, Yukiko Fu, Siyu S. Chen
Publikováno v:
The Journal of Clinical Investigation
Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance. Here, we aimed to identify a physiological signal that arises from excess caloric intake and negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d73a72eadc8e492b6388fcb3b9019da
https://doi.org/10.1172/jci126107
https://doi.org/10.1172/jci126107
Autor:
James L. Trevaskis, Victor G. Howard, David C. Hornigold, Emma Roth, Stephanie Oldham, Matthew P. Coghlan, Sarah Will, Clemence Blouet
Publikováno v:
Appetite
Combination approaches for the treatment of metabolic diseases such as obesity and diabetes are becoming increasingly relevant. Co-administration of a glucagon-like peptide-1 receptor (GLP-1R) agonist with a cholecystokinin receptor-1 (CCKR1) agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeb2017fb8104b2d5b1e6141972ede5
https://doi.org/10.1016/j.appet.2018.05.131
https://doi.org/10.1016/j.appet.2018.05.131
Autor:
Rebecca E. Harvey, Michael A. Cowley, Pradip K. Saha, Claudia Thalmann, Weiyi Chen, Mark W. Sleeman, Victor G. Howard, Lawrence Chan, Kristina Youngs, Tara Jois
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 11, Pp 1381-1394 (2017)
Molecular Metabolism, Vol 6, Iss 11, Pp 1381-1394 (2017)
Objective Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ee407425fa0582ea96593a0bc60a36
https://doi.org/10.1016/j.molmet.2017.07.006
https://doi.org/10.1016/j.molmet.2017.07.006
Autor:
Victor G. Howard, David C. Hornigold, Stephanie Oldham, Christopher J. Rhodes, Jacqueline Naylor, Isabelle Sermadiras, Chrsitan Rivera, Sarah Will, Shimona Madalli
Publikováno v:
Diabetes. 68
Bariatric surgery can result in profound weight loss and remission of type 2 diabetes. Following meal consumption post-surgery, patients exhibit an exaggerated increase in the circulating levels of the enteroendocrine L-cell peptides peptide YY (PYY)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81088ac6eddca69d494c31fd07e4d883
https://doi.org/10.2337/db19-2002-p
https://doi.org/10.2337/db19-2002-p
Autor:
Christopher J. Rhodes, Brandon B. Boland, Stephanie Oldham, Sarah Will, Michelle Beaton, James L. Trevaskis, Joe Grimsby, Victor G. Howard
Publikováno v:
Diabetes. 67
One proposed mechanism for the effects of bariatric surgery is the enhanced postprandial release of enteroendocrine L-cell hormones, such as PYY and GLP-1. Four week co-administration of Fc-conjugated GLP-1R and Y2R-selective agonists induced weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8ec6a32bb1f0514be8d8fe4ce7db7a
https://doi.org/10.2337/db18-1909-p
https://doi.org/10.2337/db18-1909-p
Publikováno v:
Diabetes. 67
MEDI0382 is a potent glucagon-like-peptide-1 (GLP-1) and glucagon receptor dual agonist that inhibits feeding and induces weight loss in mice. To test whether MEDI0382-mediated improvements in metabolism require leptin signaling, we determined its ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11aed48ce9d7b1b0822c7c222cabf230
https://doi.org/10.2337/db18-1891-p
https://doi.org/10.2337/db18-1891-p