Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV.

Autor: Victor G Valcour, Serena S Spudich, Napapon Sailasuta, Nittaya Phanuphak, Sukalaya Lerdlum, James L K Fletcher, Eugene D M B Kroon, Linda L Jagodzinski, Isabel E Allen, Collin L Adams, Peeriya Prueksakaew, Bonnie M Slike, Joanna M Hellmuth, Jerome H Kim, Jintanat Ananworanich, SEARCH 010/RV 254 Study Group

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142600 (2015)

To compare central nervous system (CNS) outcomes in participants treated during acute HIV infection with standard combination antiretroviral therapy (cART) vs. cART plus integrase inhibitor and CCR5 antagonist (cART+).24-week randomized open-label pr

Externí odkaz: https://doaj.org/article/66ed0c7b54184a0ebee99c6b4ff9c1c5

Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells

Autor: Hiroshi Takata, Juyeon C. Kakazu, Julie L. Mitchell, Eugene Kroon, Donn J. Colby, Carlo Sacdalan, Hongjun Bai, Philip K. Ehrenberg, Aviva Geretz, Supranee Buranapraditkun, Suteeraporn Pinyakorn, Jintana Intasan, Somporn Tipsuk, Duanghathai Suttichom, Peeriya Prueksakaew, Thep Chalermchai, Nitiya Chomchey, Nittaya Phanuphak, Mark de Souza, Nelson L. Michael, Merlin L. Robb, Elias K. Haddad, Trevor A Crowell, Sandhya Vasan, Victor G. Valcour, Daniel C. Douek, Rasmi Thomas, Morgane Rolland, Nicolas Chomont, Jintanat Ananworanich, Lydie Trautmann, Nipat Teeratakulpisarn, Supanit Pattanachaiwit, Somchai Sriplienchan, Ponpen Tantivitayakul, Ratchapong Kanaprach, Kiat Ruxrungtham, Netsiri Dumrongpisutikul, Ponlapat Rojnuckarin, Suthat Chottanapund, Kultida Poltavee, Tassanee Luekasemsuk, Hathairat Savadsuk, Suwanna Puttamsawin, Khunthalee Benjapornpong, Nisakorn Ratnaratorn, Kamonkan Tangnaree, Chutharat Munkong, Rommanus Thaimanee, Patcharin Eamyoung, Sasiwimol Ubolyam, Sukalya Lerdlum, Sopark Manasnayakorn, Rugsun Rerknimitr, Sunee Sirivichayakul, Phandee Wattanaboonyongcharoen, Jessica Cowden, Alexandra Schuetz, Siriwat Akapirat, Nampueng Churikanont, Saowanit Getchalarat, Denise Hsu, Ellen Turk, Oratai Butterworth, Mark Milazzo, Leigh Anne Eller, Julie Ake, Serena Spudich, CAPT Lawrence Fox, Silvia Ratto-Kim, Victor DeGruttola, Yotin Chinvarun, Pasiri Sithinamsuwan, James Fletcher, Bruce Shiramizu

Publikováno v: EBioMedicine, Vol 84, Iss , Pp 104253- (2022)

Summary: Background: Harnessing CD8+ T cell responses is being explored to achieve HIV remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the

Externí odkaz: https://doaj.org/article/9613185aa1dd427ea563c0aff33f6788

Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy

Autor: Thomas A. Premeaux, Shireen Javandel, Kalei R. J. Hosaka, Meredith Greene, Nicholas Therrien, Isabel E. Allen, Michael J. Corley, Victor G. Valcour, Lishomwa C. Ndhlovu

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)

The prevalence of age-related comorbidities is increased in people living with HIV, even in those well-controlled on combination antiretroviral therapy (ART). Persistent immune activation and inflammation may play pivotal roles in the pathogenesis; h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2c6a1b44eebcd7ba6bd83ef39281cc
http://europepmc.org/articles/PMC7338430

Cognitive trajectories over 4 years among HIV-infected women with optimal viral suppression

Autor: Leah H, Rubin, Pauline M, Maki, Gayle, Springer, Lorie, Benning, Kathryn, Anastos, Deborah, Gustafson, Maria C, Villacres, Xiong, Jiang, Adaora A, Adimora, Drenna, Waldrop-Valverde, David E, Vance, Hector, Bolivar, Christine, Alden, Eileen M, Martin, Victor G, Valcour, Joel, Milam

Publikováno v: Neurology. 89:1594-1603

Objective:To determine whether persistent viral suppression alters cognitive trajectories among HIV-infected (HIV+) women on combination antiretroviral therapy (cART) by investigating performance longitudinally in uninfected (HIV−) and 3 groups of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251c27b910dc83d98a64c956b09e807d
https://doi.org/10.1212/wnl.0000000000004491

HIV DNA in CD14+ reservoirs is associated with regional brain atrophy in patients naive to combination antiretroviral therapy

Autor: Kalpana J, Kallianpur, Victor G, Valcour, Sukalaya, Lerdlum, Edgar, Busovaca, Melissa, Agsalda, Pasiri, Sithinamsuwan, Thep, Chalermchai, James L K, Fletcher, Somporn, Tipsuk, Cecilia M, Shikuma, Bruce T, Shiramizu, Jintanat, Ananworanich, Michittra, Boonchan

Publikováno v: AIDS (London, England). 28(11)

Author(s): Kallianpur, Kalpana J; Valcour, Victor G; Lerdlum, Sukalaya; Busovaca, Edgar; Agsalda, Melissa; Sithinamsuwan, Pasiri; Chalermchai, Thep; Fletcher, James LK; Tipsuk, Somporn; Shikuma, Cecilia M; Shiramizu, Bruce T; Ananworanich, Jintanat;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adaaabc225ff8afa0e3b7d4bce25c4e2
https://pubmed.ncbi.nlm.nih.gov/25232899