Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Victor G Puelles"'
Autor:
Patricia Bartsch, Christoph Kilian, Malte Hellmig, Hans-Joachim Paust, Alina Borchers, Amirrtavarshni Sivayoganathan, Leon Enk, Yu Zhao, Nikhat Shaikh, Henning Büttner, Milagros N Wong, Victor G Puelles, Thorsten Wiech, Richard Flavell, Tobias B Huber, Jan-Eric Turner, Stefan Bonn, Samuel Huber, Nicola Gagliani, Hans-Willi Mittrücker, Holger Rohde, Ulf Panzer, Christian F Krebs
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010430 (2022)
Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a major health burden worldwide. CD4+ T helper cells are involved in the immune response to S. aureus by supporting antibody production and phagocytosis. In part
Externí odkaz:
https://doaj.org/article/380fd4269d2449729d87e44af873b2c2
Autor:
Eva M Buhl, Sonja Djudjaj, Barbara M Klinkhammer, Katja Ermert, Victor G Puelles, Maja T Lindenmeyer, Clemens D Cohen, Chaoyong He, Erawan Borkham‐Kamphorst, Ralf Weiskirchen, Bernd Denecke, Panuwat Trairatphisan, Julio Saez‐Rodriguez, Tobias B Huber, Lorin E Olson, Jürgen Floege, Peter Boor
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract Kidney fibrosis is characterized by expansion and activation of platelet‐derived growth factor receptor‐β (PDGFR‐β)‐positive mesenchymal cells. To study the consequences of PDGFR‐β activation, we developed a model of primary ren
Externí odkaz:
https://doaj.org/article/ac0b8d90d0994948bb0f71372a3ae50d
Autor:
Stacey Hokke, Victor G Puelles, James A Armitage, Karen Fong, John F Bertram, Luise A Cullen-McEwen
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161578 (2016)
Increasing consumption of a high fat 'Western' diet has led to a growing number of pregnancies complicated by maternal obesity. Maternal overnutrition and obesity have health implications for offspring, yet little is known about their effects on offs
Externí odkaz:
https://doaj.org/article/3199ef7f01cf420ab6829c4edaa3208e
Autor:
Stacey N Hokke, James A Armitage, Victor G Puelles, Kieran M Short, Lynelle Jones, Ian M Smyth, John F Bertram, Luise A Cullen-McEwen
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58243 (2013)
There is strong evidence from human and animal models that exposure to maternal hyperglycemia during in utero development can detrimentally affect fetal kidney development. Notwithstanding this knowledge, the precise effects of diabetic pregnancy on
Externí odkaz:
https://doaj.org/article/354f71efdc2e42c79410921dbb514e3b
Autor:
Natasha de Zoysa, Kotaro Haruhara, David J. Nikolic-Paterson, Peter G. Kerr, Jonathan Ling, Sarah E. Gazzard, Victor G. Puelles, John F. Bertram, Luise A. Cullen-McEwen
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Corticosteroid therapy, often in combination with inhibition of the renin-angiotensin system, is first-line therapy for primary focal and segmental glomerulosclerosis (FSGS) with nephrotic-range proteinuria. However, the response to treatment is vari
Externí odkaz:
https://doaj.org/article/f1b0d3151ef243659d08ba006db972f9
Autor:
Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria Chrysopoulou, Paul Brandts, Wenjun Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja T. Lindenmeyer, Tobias B. Huber, Hartmut Schlüter, Steffen Thiel, Laura H. Mariani, Victor G. Puelles, Fabian Braun, Matthias Kretzler, Fatih Demir, Jennifer L. Harder, Markus M. Rinschen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and transcriptome trajectories over cultu
Externí odkaz:
https://doaj.org/article/39ed8a12de7946c9bcf28c0777cf6607
Autor:
Tao Zhang, Ramez Wahib, Dimitra E. Zazara, Jöran Lücke, Ahmad Mustafa Shiri, Jan Kempski, Lilan Zhao, Theodora Agalioti, Andres Pablo Machicote, Olympia Giannou, Ioannis Belios, Rongrong Jia, Siwen Zhang, Joseph Tintelnot, Hannes Seese, Julia Kristin Grass, Baris Mercanoglu, Louisa Stern, Pasquale Scognamiglio, Mohammad Fard-Aghaie, Philipp Seeger, Jonas Wakker, Marius Kemper, Benjamin Brunswig, Anna Duprée, Panagis M. Lykoudis, Anastasia Pikouli, Emmanouil Giorgakis, Pablo Stringa, Natalia Lausada, Maria Virginia Gentilini, Gabriel E. Gondolesi, Kai Bachmann, Philipp Busch, Rainer Grotelüschen, Ioannis C. Maroulis, Petra C. Arck, Ryosuke Nakano, Angus W. Thomson, Tarik Ghadban, Michael Tachezy, Nathaniel Melling, Eike-Gert Achilles, Victor G. Puelles, Felix Nickel, Thilo Hackert, Oliver Mann, Jakob R. Izbicki, Jun Li, Nicola Gagliani, Samuel Huber, Anastasios D. Giannou
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formati
Externí odkaz:
https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf
Autor:
Larissa Seifert, Gunther Zahner, Catherine Meyer-Schwesinger, Naemi Hickstein, Silke Dehde, Sonia Wulf, Sarah M. S. Köllner, Renke Lucas, Dominik Kylies, Sarah Froembling, Stephanie Zielinski, Oliver Kretz, Anna Borodovsky, Sergey Biniaminov, Yanyan Wang, Hong Cheng, Friedrich Koch-Nolte, Peter F. Zipfel, Helmut Hopfer, Victor G. Puelles, Ulf Panzer, Tobias B. Huber, Thorsten Wiech, Nicola M. Tomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN
Externí odkaz:
https://doaj.org/article/c71d3e45f83243fc953b6a19b9d58113
Autor:
Steven Schepanski, Mattia Chini, Veronika Sternemann, Christopher Urbschat, Kristin Thiele, Ting Sun, Yu Zhao, Mareike Poburski, Anna Woestemeier, Marie-Theres Thieme, Dimitra E. Zazara, Malik Alawi, Nicole Fischer, Joerg Heeren, Nikita Vladimirov, Andrew Woehler, Victor G. Puelles, Stefan Bonn, Nicola Gagliani, Ileana L. Hanganu-Opatz, Petra C. Arck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
During pregnancy, maternal cells are transferred to the fetus, where they can reach the developing brain. In this study, the authors demonstrate that these maternal cells play an important role in neurodevelopment.
Externí odkaz:
https://doaj.org/article/f28f78dbe76547abbc4cadf7463e2b41
Autor:
Fabian Braun, Ahmed Abed, Dominik Sellung, Manuel Rogg, Mathias Woidy, Oysten Eikrem, Nicola Wanner, Jessica Gambardella, Sandra D. Laufer, Fabian Haas, Milagros N. Wong, Bernhard Dumoulin, Paula Rischke, Anne Mühlig, Wiebke Sachs, Katharina von Cossel, Kristina Schulz, Nicole Muschol, Sören W. Gersting, Ania C. Muntau, Oliver Kretz, Oliver Hahn, Markus M. Rinschen, Michael Mauer, Tillmann Bork, Florian Grahammer, Wei Liang, Thorsten Eierhoff, Winfried Römer, Arne Hansen, Catherine Meyer-Schwesinger, Guido Iaccarino, Camilla Tøndel, Hans-Peter Marti, Behzad Najafian, Victor G. Puelles, Christoph Schell, Tobias B. Huber
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Current therapies for Fabry disease are based on reversing intracellular accumulation of globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated stabilization of the defective enzyme, thereby alleviating lysosomal dysfun
Externí odkaz:
https://doaj.org/article/c82d0427278d4ae092a98644e9de535c